Zeolitic imidazolate framework-8 encapsulated with Mo-based polyoxometalates as surfaces with antibacterial activity against <i>Escherichia coli</i>

Abdelkhalek, Mariam M.; Mohamed, Aya M.; Abdallah, Rehab Z.; Khedr, Ghada E.; Siam, Rania; Allam, Nageh K.

doi:10.1039/d4na00142g

Nanoscale Adv.

2024

DOI: 10.1039/d4na00142g

|View full text |Cite

Zeolitic imidazolate framework-8 encapsulated with Mo-based polyoxometalates as surfaces with antibacterial activity against Escherichia coli

Mariam M. Abdelkhalek,

Aya M. Mohamed,

Rehab Z. Abdallah

et al.

Abstract: Bacterial infections represent a major global health concern, causing millions of deaths and significant economic burdens. The development of antibacterial nanoporous surfaces with potential mechano-bactericidal effects can revolutionize infection control...

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article4

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Rational design of 2D Co-ZIF-L via optimizing the linker: Metal ions molar ratio for high performance asymmetric supercapacitors

Draz,

Mohamed,

El Sharkawy

et al. 2024

Journal of Energy Storage

View full text Add to dashboard Cite

Rational design of 2D Co-ZIF-L via optimizing the linker: Metal ions molar ratio for high performance asymmetric supercapacitors

Draz,

Mohamed,

El Sharkawy

et al. 2024

Journal of Energy Storage

View full text Add to dashboard Cite

Polyoxometalates and their composites for antimicrobial applications: Advances, mechanisms and future prospects

Ma,

Chen,

Dong

et al. 2025

Journal of Inorganic Biochemistry

View full text Add to dashboard Cite

Antimicrobial Efficacy of Cubic, Single-Leaf, and Flower-like Zeolitic Imidazolate Frameworks

Zhang,

Cai,

et al. 2024

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Zeolite imidazolate frameworks (ZIFs) have been widely used in drug delivery and antibacterial applications due to their highly controllable structure and pore size. However, the relationship between the structure of ZIFs and their antibacterial efficacy has not been fully elucidated. In this study, three ZIFs with uniform sizes and specific morphologies were synthesized: cubic (Z-8), leaf-like (Z-L), and flower-like (FZ-L). Flow cytometry was employed to assess the effects of these materials on Bacillus subtilis and Escherichia coli at different concentrations and exposure times. Results showed that sharp-edged ZIFs possess enhanced antibacterial effects. Specifically, FZ-L exhibited the lowest minimum inhibitory concentration of 400 μg/mL and a minimum bactericidal concentration of 20 μg/mL, which can kill bacteria effectively and rapidly. Further study on the antibacterial mechanisms showed that these materials do not produce reactive oxygen species (ROS) themselves but induce ROS production in bacteria and accelerate bacterial death. Biocompatibility studies suggested that ZIFs have minimal toxicity to human cells, indicating their potential in biomedical applications. This research provides insights into the antibacterial mechanisms of ZIFs, which can support their development for antimicrobial use.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Zeolitic imidazolate framework-8 encapsulated with Mo-based polyoxometalates as surfaces with antibacterial activity against Escherichia coli

Abstract: Bacterial infections represent a major global health concern, causing millions of deaths and significant economic burdens. The development of antibacterial nanoporous surfaces with potential mechano-bactericidal effects can revolutionize infection control...

Cited by 4 publications

References 67 publications

Rational design of 2D Co-ZIF-L via optimizing the linker: Metal ions molar ratio for high performance asymmetric supercapacitors

Rational design of 2D Co-ZIF-L via optimizing the linker: Metal ions molar ratio for high performance asymmetric supercapacitors

Polyoxometalates and their composites for antimicrobial applications: Advances, mechanisms and future prospects

Antimicrobial Efficacy of Cubic, Single-Leaf, and Flower-like Zeolitic Imidazolate Frameworks

Contact Info

Product

Resources

About