Zeranol may increase the risk of leptin-induced neoplasia in human breast

Xu, Pingping; Ye, Weiping; Zhong, Saiyi; Jen, Robert; Li, Hong; Feng, Eric; Lin, Shu-Hong; Liu, Jieyu; Lin, Yi‐Chia

doi:10.3892/ol.2010.214

Cited by 6 publications

(2 citation statements)

References 37 publications

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“…α‐ZAL exposure (3 nM and higher) of primary human normal breast epithelial cells resulted in proliferation by upregulation of cyclin D1 expression and this cell sensitivity was further increased by additional leptin exposure (Xu et al., ).…”

Section: Toxicitymentioning

confidence: 99%

Appropriateness to set a group health‐based guidance value for zearalenone and its modified forms

Hoogenboom¹

2016

EFS2

101

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The current tolerable daily intake (TDI) for zearalenone (ZEN) of 0.25 lg/kg body weight (bw) per day established by the EFSA Panel for Contaminants in the Food Chain (CONTAM Panel) in 2011 is based on oestrogenicity in pigs. No new studies were identified to change this TDI. The modified forms of ZEN identified are phase I and phase II metabolites. Phase I metabolites are mainly formed through reduction. Phase II metabolites are formed by conjugation of ZEN and its phase I metabolites with glucose or sulfate, and in animals glucuronic acid. The few data on the occurrence of modified forms of ZEN indicated that cereal-based foods are the main source, containing amounts varying from a few up to 100% of ZEN. Most of the phase I metabolites have oestrogenic activity and it is assumed that their combined action will be additive. The CONTAM Panel found it appropriate to set a group TDI of 0.25 lg/kg bw per day expressed as ZEN equivalents for ZEN and its modified forms (phase I and phase II metabolites). To account for differences in in vivo oestrogenic potency, each phase I metabolite was assigned a potency factor relative to ZEN to be applied to exposure estimates of the respective ZEN metabolites. It was assumed that conjugates (phase II metabolites) of ZEN and its phase I metabolites, which per se have no oestrogenic activity, will be cleaved releasing ZEN and its phase I metabolites. These conjugates were assigned the same relative potency factors as their aglycones. The overall uncertainty associated with the present assessment is considered as high. It would rather overestimate than underestimate any risk of modified ZEN. Several aspects of the uncertainty could be reduced provided more data are made available on oestrogenicity of modified ZEN, in particular a-zearalenol, in pigs.

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Section: Toxicitymentioning

confidence: 99%

Appropriateness to set a group health‐based guidance value for zearalenone and its modified forms

Hoogenboom¹

2016

EFS2

101

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“…Zeranol mempunyai efek estrogenik yang kuat (Leffers et al, 2001;Sang-Hee et al, 2010). Menurut Smith et al (1989), Leffers et al (2001), Takemura et al (2007), Weiping Ye et al (2010), Pingping Xu et al (2011) dan Ming-Kun et al (2013), zeranol dapat menstimulasi proliferasi jaringan payudara, menginduksi luka di testis, dan menginduksi terjadinya neoplasia hepatik. Pada rodensia, Yuri et al (2004)…”

Section: Perbandingan Kandungan Residu Zeranol Dalam Daging Yang Diimunclassified

"Residu Zeranol dalam Daging Sapi yang Diimpor dari Australia dan Selandia Baru Melalui Pelabuhan Tanjung Priok (ZERANOL RESIDUE IN BEEF MEAT IMPORTED FROM AUSTRALIA AND NEW ZEALAND THROUGH THE PORT OF TANJUNG PRIOK)"

Khadijah

Latif²,

Sanjaya³

2015

jveteriner

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Zeranol merupakan salah satu hormon pertumbuhan sintetis yang dibuat dari mikotoksin dan dapat memengaruhi kesehatan manusia. Tujuan dari penelitian ini adalah untuk menganalisis keberadaan residu zeranol pada daging sapi impor yang berasal dari Australia dan Selandia Baru. Semua daging sapi impor tersebut diuji dengan Enzyme-Linked Immunosorbent Assay (ELISA). Hasil pengujian menunjukkan 5 dari 59 sampel (8,5%) dari Australia dan 1 dari 59 sampel (1,7%) dari Selandia Baru mengandung residu zeranol, dengan rataan konsentrasi masing-masing adalah 0,644±0,157 ppb dan 0,680±0,00 ppb. Tidak ada perbedaan kandungan residu zeranol yang nyata antara daging asal kedua Negara pengekspor tersebut. Hasil tersebut menunjukkan bahwa daging sapi asal Australia dan Selandia Baru mengandung zeranol dan kandungan residu zeranol berada di bawah angka yang ditetapkan oleh Standar Nasional Indonesia yakni sebesar 2 ppb. Kata-kata kunci: zeranol, residu, daging sapi impor, ELISA

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Determination of Zearalanol and Its Analog Zearalanone in Muscle Tissues by Amplified Luminescent Proximity Homogeneous Assay (AlphaLISA)

Gong

Nie

et al. 2016

Food Anal. Methods

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Zeranol may increase the risk of leptin-induced neoplasia in human breast

Cited by 6 publications

References 37 publications

Appropriateness to set a group health‐based guidance value for zearalenone and its modified forms

Appropriateness to set a group health‐based guidance value for zearalenone and its modified forms

"Residu Zeranol dalam Daging Sapi yang Diimpor dari Australia dan Selandia Baru Melalui Pelabuhan Tanjung Priok (ZERANOL RESIDUE IN BEEF MEAT IMPORTED FROM AUSTRALIA AND NEW ZEALAND THROUGH THE PORT OF TANJUNG PRIOK)"

Determination of Zearalanol and Its Analog Zearalanone in Muscle Tissues by Amplified Luminescent Proximity Homogeneous Assay (AlphaLISA)

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