Zero-order controlled release of ciprofloxacin-HCl from a reservoir-based, bioresorbable and elastomeric device

Abstract

A reservoir-based device constructed of a completely biodegradable elastomer can enable many new implantation and insertion options for localized drug therapy, particularly in the case of urological therapies. We performed an in vitro performance evaluation of an implantable, bioresorbable device that supplies short-term controlled release of ciprofloxacin-HCl (CIP). The proposed device functions through a combination of osmosis and diffusion mechanisms to release CIP for short-term therapies of a few weeks duration. Poly(glycerol-co-sebacic acid) (PGS) was cast in a tubular geometry with solid drug powder packed into its core and a micro-machined release orifice drilled through its wall. Drug release experiments were performed to determine the effective release rate from a single orifice and the range of orifice sizes in which controlled zeroorder release was the main form of drug expulsion from the device. It is demonstrated that PGS is sufficiently permeable to water to allow the design of an elementary osmotic pump for drug delivery. Indeed, PGS's water permeability is several orders of magnitude larger than commonly used cellulose acetate for elementary osmotic pumps.

Biodegradable Elastomers for Tissue Engineering and Cell–Biomaterial Interactions

“…Elastomers such as PGS have demonstrated exceptional promise for neural tissue engineering applications. [107] PGS can also be fabricated into small diameter tubes, [108] which could have potential applications as biodegradable conduits to enhance peripheral nerve repair. The general lack of observed swelling in synthetic elastomers upon hydration and subsequent degradation would be of particular interest for this application.…”

Synthesis, Characterization and 3D Micro-Structuring via 2-Photon Polymerization of Poly(glycerol sebacate)-Methacrylate–An Elastomeric Degradable Polymer

“…Porous PGS scaffolds have been used to support the growth of cardiac tissue [7,8], blood vessels [9,10], and cartilage [11][12][13]. Additionally, PGS has also been used as a degradable drug carrier for antibiotics and anticancer drugs [14,15].…”

Polymeric implants of diclofenac for site specific and prolonged drug delivery for use in orthopedic or arthritic patients.

“…Formulation F1 prepared using (3:1) gelatin and sodium alginate showed highest percent cumulative drug release while the formulation F2 prepared (1:3) gelatin and sodium alginate showed lowest release at the end of 24 h. The n value obtained from the korsmeyer -peppas kinetic model or curve is known as the release exponent and it indicates the mechanism of drug release [16][17][18]. The value of n for implants formulation was between 0.45 to 0.89 and this indicated that the release mechanism was Anomalous transport mechanism.…”