Zerumbone, a major sesquiterpene from Syringa pinnatifolia Hemsl., exerts the sedative effect by regulating GABAergic nervous system

The Ethanol Extract of Syringa oblata Heartwood, a Mongolian Folk Medicine Containing Major Lignans, Exerts Analgesic and Sedative Effects on Mice

“…Mice of gavage administration were randomly divided into 5 groups (n = 8): ESO-L (20 mg/kg), ESO-M (40 mg/kg), ESO-H (80 mg/kg), positive control diazepam (1.5 mg/kg), [3] and model (vehicle, water) group. Following that, mice were placed into a small animal autonomous activity recorder (Jinan Yiyan Science & Technology Development Co., Ltd., Shandong, China) 0.5 h after the administration.…”

“…According to the theory of Chinese medicine, the medicinal parts of SO include the leaves, buds, flowers, branches, and bark, which have been used to treat hepatitis, intestinal disorders, and diarrhea, whereas the heartwood of SO is used as an MFM for its efficacy of clearing heat and inhibiting the partial prosperity of "Khii" in the theory of traditional Mongolian medicine. [2] Since the partial prosperity of "Khii" is one of the basic pathological mechanisms resulting in heart diseases, insomnia, and pain in the theory of traditional Mongolian medicine, [3] SO is clinically used to treat pain, insomnia, fever, and cardiovascular diseases, and commonly used as a substitution to the peeled stems of Syringa pinnatifolia. [4] Contemporary studies have shown that SO as TCM has effects of anti-inflammation, antioxidation, antibiosis, and hepatoprotection, [5 -9] and contains iridoids, phenylpropanoids, triterpenoids, phenylethanes, and flavonoids.…”