2019
DOI: 10.1016/j.ejpb.2019.09.007
|View full text |Cite
|
Sign up to set email alerts
|

Zeta potential changing self-emulsifying drug delivery systems: A promising strategy to sequentially overcome mucus and epithelial barrier

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

2
18
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
4
1
1

Relationship

1
5

Authors

Journals

citations
Cited by 42 publications
(20 citation statements)
references
References 38 publications
2
18
0
Order By: Relevance
“…The in vitro Transwell diffusion model described previously was used to evaluate the micellar droplets’ abilities to penetrate the intestinal porcine mucus [ 2 ]. Porcine mucus was collected from fresh pig intestines bought from a local slaughterhouse and stored on ice.…”
Section: Methodsmentioning
confidence: 99%
See 3 more Smart Citations
“…The in vitro Transwell diffusion model described previously was used to evaluate the micellar droplets’ abilities to penetrate the intestinal porcine mucus [ 2 ]. Porcine mucus was collected from fresh pig intestines bought from a local slaughterhouse and stored on ice.…”
Section: Methodsmentioning
confidence: 99%
“…Oral delivery is the most common route of drug delivery and offers several advantages for localized and systemic therapeutics [ 1 , 2 , 3 ]. However, the intestinal mucosal barriers, which predominantly comprise the mucus gel layer and absorptive mucosa, limit the delivery of many drugs, especially hydrophobic ones [ 4 , 5 ].…”
Section: Introductionmentioning
confidence: 99%
See 2 more Smart Citations
“…[ 31 ] The mucin glycoprotein imparts strong electrostatic interactions with the positively charged NCs, which thus traps the NCs in the mucus matrix followed by fast muco‐ciliary clearance, ultimately preventing the NCs from reaching the underlying alveolar spaces. [ 32,33 ] The mucus secretion becomes even pronounced in patients suffering from severe pulmonary inflammation (such as critical patients of COVID‐19), which dramatically compromises the therapeutic efficacy in the way of intratracheal administration and inhalation. [ 34 ] As such, siRNA delivery systems with potent mucus‐penetrating capabilities are highly imperative toward the success of pulmonary gene silencing.…”
Section: Introductionmentioning
confidence: 99%