Zeta potential measurements for non-spherical colloidal particles – Practical issues of characterisation of interfacial properties of nanoparticles

Marín, Rodrigo Renato Retamal; Babick, Frank; Hillemann, Lars

doi:10.1016/j.colsurfa.2017.04.010

Cited by 54 publications

(19 citation statements)

References 19 publications

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“…Previous studies have shown that the PSD of, e.g., FS may be highly polydisperse [ 20 , 54 ]) and covers a wide range from of a few nanometers up to several micrometers [ 18 , 19 , 20 ]. As outlined above ( Section 2.3 ), the appropriate granulometric analysis of such samples requires a combination of LD and DLS.…”

Section: Resultsmentioning

confidence: 99%

“…To avoid re-agglomeration, the particles were placed in a liquid environment that ensured high surface charges. The pH value of prepared silica suspension is far from the isoelectric point of silica (e.g., pH 1.8–2.5) and it has a low electric conductivity (see Table 2 ) [ 53 , 54 , 55 ]. Powders were dispersed by different treatments: Firstly, by means of a paddle stirrer (PS) (model RW 11 basic, IKA, Staufen, Germany), which administered the lowest input of mechanical energy into the suspension and which was used for the homogenization of SAS suspensions.…”

Section: Methodsmentioning

confidence: 99%

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Effects of Sample Preparation on Particle Size Distributions of Different Types of Silica in Suspensions

et al. 2018

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The granulometric characterization of synthetic amorphous silica (SAS) nanomaterials (NMs) still demands harmonized standard operation procedures. SAS is produced as either precipitated, fumed (pyrogenic), gel and colloidal SAS and these qualities differ, among others, with respect to their state of aggregation and aggregate strength. The reproducible production of suspensions from SAS, e.g., for biological testing purposes, demands a reasonable amount of dispersing energy. Using materials representative for each of the types of SAS, we employed ultrasonic dispersing (USD) at energy densities of 8–1440 J/mL and measured resulting particle sizes by dynamic light scattering and laser diffraction. In this energy range, USD had no significant impact on particle size distributions of colloidal and gel SAS, but clearly decreased the particle size of precipitated and fumed SAS. For high energy densities, we observed a considerable contamination of SAS suspensions with metal particles caused by abrasion of the sonotrode’s tip. To avoid this problem, the energy density was limited to 270 J/mL and remaining coarse particles were removed with size-selective filtration. The ultrasonic dispersion of SAS at medium levels of energy density is suggested as a reasonable compromise to produce SAS suspensions for toxicological in vitro testing.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Effects of Sample Preparation on Particle Size Distributions of Different Types of Silica in Suspensions

et al. 2018

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“…The negatively charged pectin can be adsorbed on the surface of GPs to form composite particles, making the zeta‐potential of system shifting to a negative value. The maximum zeta‐potential value was obtained by GAPs, indicating that it has good stability (Retamal Marín et al , 2017). The particle size of GPs was about 126 nm, following the adding of pectin, and the particle size tended to increase significantly.…”

Section: Resultsmentioning

confidence: 99%

Gliadin/amidated pectin core–shell nanoparticles for stabilisation of Pickering emulsion

Jiang

Zhu

2020

Int J of Food Sci Tech

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Over the past decade, edible colloidal particle-stabilised Pickering emulsions have regained research interest. However, little information is available regarding the application of amidated pectin in stabilising Pickering emulsions. In this work, a 'two-step' method was used to synthesise gliadin/pectin composite colloidal particles. The effects of pectin type, particle ratio, particle amount and oil fraction on the formation and stability of the resulting Pickering emulsion were systematically investigated by particle size and microscopy. The results showed that the particles formed after the addition of amidated pectin could better stabilise the o/w Pickering emulsion with a concentration of 2%, lower than that of the gliadin colloid particles. Confocal laser scanning microscopy (CLSM) revealed the cross-sectional structure and the attachment of protein particles to the external interface. These results may provide reference for the selection of shell materials for Pickering colloidal particles (especially gliadin) in the future.

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“…Prior to the electrophoretic mobility measurements, all the samples were diluted with ultra-purified water, and the measurements were carried out at 25 °C. The conversion of electrophoretic mobility to the zeta potential was performed using the following Helmholtz–Smoluchowski equation [26]: ζ = E (4πη/ε) where ζ is the zeta potential (mV), E is the electrophoretic mobility, η is the viscosity of the dispersion medium (water 0.8904 cp) and ε is the dielectric constant of the solvent (water, 78.54).…”

Section: Methodsmentioning

confidence: 99%

A novel praziquantel solid lipid nanoparticle formulation shows enhanced bioavailability and antischistosomal efficacy against murine S. mansoni infection

et al. 2019

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Background Schistosomiasis is responsible for a considerable global disease burden. This work aimed to improve the therapeutic outcome of the only available antischistosomal drug worldwide, praziquantel (PZQ), by incorporating it into a novel carrier, “solid lipid nanoparticles (SLNs)”, to enhance its solubility, bioavailability and efficacy. A simple, cost-effective method was used to prepare SLN-PZQ. Results Compared to market PZQ (M-PZQ), SLN-PZQ was more bioavailable, as denoted by higher serum concentrations in both normal and infected mice where elevated K a , AUC 0–24 , C max , and t 1/2e with a decrease in k el were demonstrated. The AUC 0–24 for SLN-PZQ in normal and Schistosoma mansoni -infected groups was almost nine- and eight-fold higher, respectively, than that for M-PZQ in corresponding groups. In normal and S. mansoni -infected mice, SLN-PZQ was detectable in serum at 24 h, while M-PZQ completely vanished 8 h post-treatment. Additionally, enhanced absorption with extended residence time was recorded for SLN-PZQ. Compared to M-PZQ, SLN-PZQ revealed superior antischistosomal activity coupled with enhanced bioavailability in all treated groups where higher percentages of worm reduction were recorded with all dosages tested. This effect was especially evident at the lower dose levels. The ED 95 of SLN-PZQ was 5.29-fold lower than that of M-PZQ, with a significantly higher reduction in both the hepatic and intestinal tissue egg loads of all treated groups and almost complete disappearance of immature deposited eggs (clearly evident at the low dose levels). Conclusions SLN-PZQ demonstrated enhanced PZQ bioavailability and antischistosomal efficacy with a safe profile despite the prolonged residence in the systemic circulation.

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Zeta potential measurements for non-spherical colloidal particles – Practical issues of characterisation of interfacial properties of nanoparticles

Cited by 54 publications

References 19 publications

Effects of Sample Preparation on Particle Size Distributions of Different Types of Silica in Suspensions

Effects of Sample Preparation on Particle Size Distributions of Different Types of Silica in Suspensions

Gliadin/amidated pectin core–shell nanoparticles for stabilisation of Pickering emulsion

A novel praziquantel solid lipid nanoparticle formulation shows enhanced bioavailability and antischistosomal efficacy against murine S. mansoni infection

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