ZEUS (ZIF-based electrochemical ultrasensitive screening) device for isopentane analytics with focus on lung cancer diagnosis

Banga, Ivneet; Paul, Anirban; Sardesai, Abha; Muthukumar, Sriram; Prasad, Shalini

doi:10.1039/d1ra03093k

Cited by 17 publications

(8 citation statements)

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“…(B) Schematic illustration of a fabricated hand-held prototype device for isopentane sensing. Reproduced from ref with permission from RSC Advances and the Royal Society of Chemistry.…”

Section: Electrochemical Detection Of Gases and Vocs With Focus On En...mentioning

confidence: 99%

“…The developed bifunctional probe system was able to accomplish a limit of detection of 400 ppb for ammonia sensing (Figure A). In another work by Banga et al, the authors have leveraged the capacitive property of RTIL and encapsulated it inside ZIF-8 for detection of isopentane . The level of this hydrocarbon varies because of oxidative stress, as found in lung cancer patients.…”

Section: Electrochemical Detection Of Gases and Vocs With Focus On En...mentioning

confidence: 99%

“…In another work by Banga et al, the authors have leveraged the capacitive property of RTIL and encapsulated it inside ZIF-8 for detection of isopentane. 80 The level of this hydrocarbon varies because of oxidative stress, as found in lung cancer patients. The authors demonstrated the fabrication of a proof-of-concept hand-held device that can be utilized for the qualitative screening of isopentane levels.…”

Section: ■ Conventional Noninvasive Techniques For Detecting Gas-phas...mentioning

confidence: 99%

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Recent Advances in Gas Detection Methodologies with a Special Focus on Environmental Sensing and Health Monitoring Applications─A Critical Review

et al. 2023

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With the expansion of the Internet-of-Things (IoT), the use of gas sensors in the field of wearable technology, smart devices, and smart homes has increased manifold. These gas sensors have two key applications�one is the detection of gases present in the environment and the other is the detection of Volatile Organic Compounds (VOCs) that are found in the breath. In this review, we focus systematically on the advancements in the field of various spectroscopic methods such as mass spectrometry-based analysis and point-of-care approach to detect VOCs and gases for environmental monitoring and disease diagnosis. Additionally, we highlight the development of smart sensors that work on the principle of electrochemical detection and provide examples of the same through an extensive literature review. At the end of this review, we highlight various challenges and future perspectives.

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“…(B) Schematic illustration of a fabricated hand-held prototype device for isopentane sensing. Reproduced from ref with permission from RSC Advances and the Royal Society of Chemistry.…”

Section: Electrochemical Detection Of Gases and Vocs With Focus On En...mentioning

confidence: 99%

Section: Electrochemical Detection Of Gases and Vocs With Focus On En...mentioning

confidence: 99%

Section: ■ Conventional Noninvasive Techniques For Detecting Gas-phas...mentioning

confidence: 99%

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Recent Advances in Gas Detection Methodologies with a Special Focus on Environmental Sensing and Health Monitoring Applications─A Critical Review

et al. 2023

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“…The authors in another study 24 also explored the nonfaradaic properties of ZIF-8 by encapsulating a room temperature ionic liquid (RTIL) inside the ZIF-8 cavity. This hybrid synthesis process yields a composite compound that demonstrates dual functionality for gas sensing and is electrochemically active in nature such that it can be used for point-of-care diagnostics.…”

Section: Zif-8-based Electrochemical Sensormentioning

confidence: 99%

Engineering the ZIF-8 Pore for Electrochemical Sensor Applications─A Mini Review

et al. 2022

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Zinc imidazole framework-8, abbreviated as ZIF-8, is a member of the metal organic framework (MOF) family. The chemical architecture of ZIF-8 consists of zinc metal duly coordinated with an organic ligand/fragment, resulting in a cagelike three-dimensional network with unique porosity. Because of such a unique architecture and physicochemical property, ZIF-8 has recently been explored in various applications such as gas storage, catalysis, electrochemical sensing, drug delivery, etc. Electrochemical sensors are currently a hot topic in scientific advances, where small, portable, Internet of Things (IoT)-enabled devices powered by electrochemical output show a newer path toward chemo and biosensor applications. The unique electrochemical property of ZIF-8 is hence explored widely for possible electrochemical sensor applications. The application and synthesis of the bare ZIF-8 have been widely reported for more than a decade. However, new scientific advancements depict tailoring the bare ZIF-8 structure to achieve smart hybrid ZIF-8 materials that show more advanced properties compared to bare ZIF-8. The framework is formed by joining inorganic (metal-containing) units with organic linkers by reticular synthesis, which results in the formation of a cross-linked crystalline network with permanent porosity. This unique porosity of ZIF-8 has recently been utilized for the encapsulation of suitable guest species to enhance the native physicochemical activity of ZIF-8. These engineered ZIF-8 materials show excellent results, especially for electrochemical sensing application. This review is intended to describe the research, including the one done by our group, where the ZIF-8 pore size is used for encapsulating nanoparticles, enzymes, and organic compounds to avail suitable sensor applications.

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“…Impedimetric sensors are very popular for building robust sensors for different applications . Two-dimensional porous materials, such as zinc-imidazole framework (ZIF-8), have recently been explored for electrochemical sensor application, especially in situ nanoparticle-encapsulated ZIF-8 shows unique sensing property and hence utilized. − In this work, we have fabricated the first of a kind impedimetric sensor device to detect a trace level of fentanyl in spiked buffer. Naloxone has been used as a receptor for signal specificity, whereas naloxone and AuNPs are both encapsulated in situ into ZIF-8 to synthesize the first of a kind selective probe, Nal-AuNPs@ZIF-8, to detect fentanyl.…”

Section: Introductionmentioning

confidence: 99%

Naloxone-AuNPs@ZIF-8-Based Impedimetric Sensor Platform for Ultrasensitive Detection of Fentanyl and Fabrication of Fen-Track Prototype for Real-Field Analysis

Paul,

Banga,

Muthukumar

et al. 2023

ACS Appl. Mater. Interfaces

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Opioids are considered to be a global threat, and we are facing the worst opioid crisis of the decade. Synthetic opioids like fentanyl are highly potent and deadly toward human body, and hence its detection is an inevitable requirement globally. Naloxone is known for its antagonist property toward fentanyl, and we performed computational simulations to find their interactions and use this principle to build the first of a kind impedimetric sensor device, transduced by 3D-ZIF-8 with in situ encapsulated naloxone-gold nanoparticles. The probe is synthesized using a unique encapsulation strategy, thoroughly characterized by various physicochemical and microscopic tools. The sensor is highly selective toward fentanyl and can detect fentanyl up to 100 ppm in a synthetic sample. A prototype device is also built based on the synthetic calibration and applied to the spiked urine sample, and the performance is evaluated using statistical and machine learning tools.

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ZEUS (ZIF-based electrochemical ultrasensitive screening) device for isopentane analytics with focus on lung cancer diagnosis

Abstract: A novel synthesized [BMIM]BF4@ZIF-8 nanocomposite for electrochemical sensing of isopentane as a biomarker for lung cancer diagnosis.

Cited by 17 publications

References 60 publications

Recent Advances in Gas Detection Methodologies with a Special Focus on Environmental Sensing and Health Monitoring Applications─A Critical Review

Recent Advances in Gas Detection Methodologies with a Special Focus on Environmental Sensing and Health Monitoring Applications─A Critical Review

Engineering the ZIF-8 Pore for Electrochemical Sensor Applications─A Mini Review

Naloxone-AuNPs@ZIF-8-Based Impedimetric Sensor Platform for Ultrasensitive Detection of Fentanyl and Fabrication of Fen-Track Prototype for Real-Field Analysis

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