Zhijing powder manages blood pressure by regulating PI3K/AKT signal pathway in hypertensive rats

Flavonoids from Lophatherum gracile Brongn. Ameliorate Liver Damages in High-Fat Diet and Streptozotocin-Induced Diabetic Mice by Regulating PI3K/AKT and NF-Kappa B Pathways

“…Te PI3K/AKT pathway is a primary insulin receptor signaling pathway, which mainly regulates energy metabolism, and the notion that the liver is the main metabolic organ directly afecting the lipid mass spectrum is widely acknowledged [25,26]. Besides, emerging views have considered that the PI3K/AKT signaling pathway plays a vital role in infammation regulation, especially the chronic liver disease by adjusting the polarization of macrophages [27]. A growing number of studies have expounded on how the PI3K/AKT pathway regulates liver functions in T2DM after medication or surgery intervention.…”

Research Progress on the Correlation Between Hypertension and Gut Microbiota

“… 141 Moreover, Zhijing powder can also regulate the signaling pathway of hypertension receptors, improve oxidative stress, and lower BP in rats with hypertension induced by cold stimulation and high salt intake. 142 …”

“…141 Moreover, Zhijing powder can also regulate the signaling pathway of hypertension receptors, improve oxidative stress, and lower BP in rats with hypertension induced by cold stimulation and high salt intake. 142 Regarding TCM decoctions for lowering BP, which include but are not limited to the examples mentioned above, their inclusion of a variety of medicinal materials allows for a combination effect of numerous bioactive components and pharmacological actions. This enables TCM decoctions to modulate the human body through multiple targets and pathways, thereby more comprehensively regulating physiological functions and achieving better antihypertensive effects.…”

Tongxinluo capsule as a multi-functional traditional Chinese medicine in treating cardiovascular disease: A review of components, pharmacological mechanisms, and clinical applications

“…The main active ingredients of traditional Chinese medicine scorpion include scorpion toxin peptides, scorpion degradation peptides, and peptides derived from scorpion venom. Experiments have shown that it has a positive effect on the prevention and treatment of cardiovascular diseases by inhibiting inflammation, improving oxidative stress in the body, anticoagulating, antithrombotic, analgesic, immune regulation, regulating vasoconstriction, regulating blood pressure, and increasing myocardial cell metabolism [ [57] , [58] , [59] , [60] ].…”

“…The main active ingredients of Chinese medicine centipede include fungal Aspergillus, centipede toxin, centipede toxin like peptide, and centipede acidic protein extracted from the intestine of centipede. Experiments have proved that these active ingredients have positive effects on the prevention and treatment of cardiovascular diseases by protecting myocardial cells, improving oxidative stress reaction in the body, regulating blood pressure, reducing total cholesterol, triglycerides, low-density lipoprotein, increasing plasma high-density lipoprotein, improving abnormal bleeding, anti atherosclerosis and other effects [ 60 , [64] , [65] , [66] ].…”