Zidovudine for Lymphocytic Interstitial Pneumonia Associated With Aids

Bach, MichaelC

doi:10.1016/s0140-6736(87)92524-4

Cited by 25 publications

(3 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Single and multidrug antiretroviral therapy has resulted in clinical and radiographic resolution of LIP in some HIV-positive patients. 110 Newer approaches have been reported, 111 including the successful treatment of LIP in a 35-year-old HIVpositive man using a three-nucleoside analog regimen. There was a marked decline in viral load, increase in CD4 count, and both radiographic and clinical resolution of pulmonary parenchymal disease.…”

Section: Diagnosis Treatment and Prognosismentioning

confidence: 99%

Lymphoid Interstitial Pneumonia

Swigris

Berry

Raffin

et al. 2002

Chest

279

239

View full text Add to dashboard Cite

Section: Diagnosis Treatment and Prognosismentioning

confidence: 99%

Lymphoid Interstitial Pneumonia

Swigris

Berry

Raffin

et al. 2002

Chest

279

239

View full text Add to dashboard Cite

“…One hypothesis for the development of IP is that an anti-HIV immune response in the lung causes the in ammatory response. HIV can be detected in the lungs of infected individuals within a year of infection, and in fact, reduction of virus load in AIDS patients by treatment with zidovidine has been shown to reduce lung disease in several patients [ 23,24] . Additionally, cytotoxic anti-HIV CD81 T cells and anti-HIV antibody have been detected in bronchoalveolar lavage ( BAL) uid from patients with HIV [ 25] .…”

Section: Discussionmentioning

confidence: 99%

Role of Virus Replication in a Murine Model of Aids-Associated Interstitial Pneumonitis

Fitzpatrick

Avdiushko

Kaplan

et al. 1999

Experimental Lung Research

View full text Add to dashboard Cite

One of the major complications of HIV infection is the development of interstitial pneumonitis (IP). IP is characterized by lymphocytic infiltration of the lung and may lead to respiratory failure in some cases. The etiology of IP is unknown although it is likely the result of an antiviral or autoimmune response occurring in the lung. To determine the role of viral replication in the development of IP, AZT was evaluated for the ability to inhibit development of lung inflammation in a murine model of retrovirus-associated IP. Mice were infected with LP-BM5 retrovirus, which induces murine AIDS. Infected mice develop IP by 4 weeks postinfection characterized by infiltration of the lung with activated T cells, B cells, and macrophages. Virus could be detected in the lungs of these mice by 2 weeks postinfection and persisted throughout the course of disease. To determine if reduction in viral load affected the disease process, infected mice were treated with AZT for varying periods postinfection and analyzed for the development of IP. Treatment with AZT resulted in a treatment time-dependent reduction of viral RNA in the lungs of infected mice compared to untreated infected mice. The reduction of viral burden in the lungs correlated with a reduction in the severity of IP and decreased production of the proinflammatory cytokines interleukin (IL)-1 beta and interferon (IFN)-gamma. These results suggest that continuous viral replication in the lung contributes to the pathogenesis of IP.

show abstract

“…There are reports of zidovudine therapy for patients with LIP; however, both clinical improvement as well as a lack of response to therapy has been documented. 23 ' 24 Since HIV infection in the lung has been documented in patients with LIP, a more thorough investigation of the potential role of zidovudine or other antiretroviral therapy is indicated.…”

Section: Lymphocytic Interstitial Pneumonitismentioning

confidence: 99%

Nonspecific and Lymphocytic Interstitial Pneumonitis in HIV-Infected Individuals

Ognibene¹

1995

Semin Respir Crit Care Med

View full text Add to dashboard Cite

Zidovudine for Lymphocytic Interstitial Pneumonia Associated With Aids

Cited by 25 publications

References 2 publications

Lymphoid Interstitial Pneumonia

Lymphoid Interstitial Pneumonia

Role of Virus Replication in a Murine Model of Aids-Associated Interstitial Pneumonitis

Nonspecific and Lymphocytic Interstitial Pneumonitis in HIV-Infected Individuals

Contact Info

Product

Resources

About