Zidovudine therapy in HIV infection: which patients should be treated and when.

Recently, the 1997 revised guidelines were published for the treatment of HIV-infected patients. These guidelines, while having a dramatic effect on the morbidity and mortality associated with HIV infection, will require the implementation of a coordinate interdisciplinary “Care Path” for each patient. This review presents updated information on the HIV life cycle and the latest approach to antiretroviral therapy. The new approach to therapy is to utilize combination antiretroviral therapy including two retroviral inhibitors with a protease inhibitor. Further, the importance of viral load has become a primary indicator of prognosis and therapy efficacy. The CD4 cell count is important, but it is of secondary significance in treatment effectiveness measurement and indication of disease progress. The complexity of the new guidelines increases the need for a well-planned interdisciplinary “Critical Path” which is then utilized for development of a patient-specific “Care Path.”

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Zidovudine therapy in HIV infection: which patients should be treated and when.

Cited by 2 publications

References 40 publications

Antiretroviral therapy for patients with HIV disease

Antiretroviral therapy for patients with HIV disease

An Integrated “Care Path” Approach: Useful for Implementation and Coordination of New Care Guidelines for Treatment of HIV Infections

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