ZIF-8 modified multifunctional injectable photopolymerizable GelMA hydrogel for the treatment of periodontitis

Liu, Yun; Li, Ting; Sun, Maolei; Cheng, Zhiqiang; Jia, Wenyuan; Jiao, Kun; Wang, Shaoru; Jiang, Kongzhao; Yong, Yang; Dai, Zhihui; Liu, Liping; Liu, Guomin; Luo, Yungang

doi:10.1016/j.actbio.2022.03.046

Cited by 110 publications

(62 citation statements)

References 54 publications

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“…Periodontitis is mainly a chronic inflammatory disease of periodontal supporting tissues caused by bacteria and is highly prevalent worldwide [ 2 , 3 ]. Currently, the promotion of dental bone and alveolar bone regeneration is considered to be the most promising treatment strategy for periodontitis [ 4 , 5 ]. Remodeling periodontal connective tissue and promoting bone and alveolar bone regeneration have been considered the most promising treatment strategy for periodontitis.…”

Section: Introductionmentioning

confidence: 99%

Study on the Mechanism of miR-146a in Gingival Mesenchymal Stem Cells

Wang

Zheng²,

Wei

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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This study aimed to investigate the molecular mechanisms of microRNA-146a (miR-146a) on gingival mesenchymal stem cells (MSCs). Gingival MSCs were isolated from the gingiva tissues of patients with periodontal disease to reveal the function of miR-146a in regulating osteoblast differentiation. miR-146a inhibits osteoblast differentiation by inhibiting phosphorylated cyclic-AMP response binding (CREB) protein translocation into the nucleus and ultimately attenuating runt-related transcription factor 2 (Runx2) expression. Furthermore, silencing miR-146a promotes the proliferation of gingival MSCs. Of note, targeted inhibition of miR-146a also inhibited LPS-induced inflammatory response and promoted the proliferation of gingival MSCs via CREB/Runx2 axis. MiR-146a is a key negative regulator of gingival MSCs proliferation and osteogenic differentiation, and targeting to reduce the miR-146a expression is essential for bone formation signaling. Therefore, we propose that miR-146a is a useful therapeutic target for the development of bone anabolic strategies.

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Section: Introductionmentioning

confidence: 99%

Study on the Mechanism of miR-146a in Gingival Mesenchymal Stem Cells

Wang

Zheng²,

Wei

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…The results were duplicated on placing the hydrogel in the periodontal pockets in vivo. The hydrogel showed good biocompatibility both in-vitro and in-vivo [6]. Therefore, from the above discussion, we could conclude that GelMA offer a great potential to be used as a biomimetic scaffold to engineer alveolar bone.…”

Section: Discussionmentioning

confidence: 78%

“…Further studies have combined GelMA with other materials such as β-tricalcium phosphate (β-TCP) [5] and, zeoliticimidazolate framework-8 (ZIF-8) [6] to enhance the properties of the scaffold in alveolar bone regeneration. Luo D et al constructed a 3D printed GelMA/β-TCP hybrid scaffold with an aim to fuse β-TCP with BMSCs, thus improving the osteogenic potential of the scaffold.…”

Section: Discussionmentioning

confidence: 99%

Gelatin Methacryloyl Bioscaffolds: A Viable Option for Alveolar Bone Tissue Engineering?

Kirthanashri¹

2022

J Regen Biol Med

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The concept of tissue engineering involves the deposition of cells on bioscaffolds in a particular location that ultimately leads to regeneration of tissues. The combinatorial effect of cells, bioscaffolds and molecular signaling factors, works conjunctly to provide exact microenvironment mimicking the native in vivo system. Alveolar bone regeneration due to its location, poses certain challenges where appropriate mechanical loading and microbial flora need addressing during construction of the scaffold [1]. Three dimensional (3D) bioprinting has unfolded vast possibilities for bone regeneration through fabrication of 3D constructs that support adhesion and proliferation of pleuripotent stem cells in desired location. 3D printing allows individual-specific construction of scaffolds of a certain shape and size that allow regeneration of bone through cellular proliferation, differentiation, and molecular-signalling pathways in a guided fashion.

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“…Zeolitic imidazolate framework-8 is a porous crystalline material self-assembled by zinc ions and 2-methylimidazole ligands, with a large specific surface area, high porosity, easy synthesis, and controllable dimensions, and it has been applied in the treatment of periodontitis and bone regeneration [ 87 , 88 ]. Liu, Y et al [ 89 ] developed a nano-injectable photosensitive GelMA composite hydrogel loaded with ZIF-8 for the treatment of periodontitis. The ZIF-8/GelMA hydrogel could release Zn 2+ continuously and had good cytocompatibility.…”

Section: Components Of Hydrogel In Periodontal Tissue Regenerationmentioning

confidence: 99%

Advances of Hydrogel Therapy in Periodontal Regeneration—A Materials Perspective Review

Mao-xue

Yang

et al. 2022

Gels

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Hydrogel, a functional polymer material, has emerged as a promising technology for therapies for periodontal diseases. It has the potential to mimic the extracellular matrix and provide suitable attachment sites and growth environments for periodontal cells, with high biocompatibility, water retention, and slow release. In this paper, we have summarized the main components of hydrogel in periodontal tissue regeneration and have discussed the primary construction strategies of hydrogels as a reference for future work. Hydrogels provide an ideal microenvironment for cells and play a significant role in periodontal tissue engineering. The development of intelligent and multifunctional hydrogels for periodontal tissue regeneration is essential for future research.

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ZIF-8 modified multifunctional injectable photopolymerizable GelMA hydrogel for the treatment of periodontitis

Cited by 110 publications

References 54 publications

Study on the Mechanism of miR-146a in Gingival Mesenchymal Stem Cells

Study on the Mechanism of miR-146a in Gingival Mesenchymal Stem Cells

Gelatin Methacryloyl Bioscaffolds: A Viable Option for Alveolar Bone Tissue Engineering?

Advances of Hydrogel Therapy in Periodontal Regeneration—A Materials Perspective Review

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