Zika virus: A primer for clinicians

Flores, Michelle S.; Burgess, Timothy; Rajnik, Michael

doi:10.3949/ccjm.83a.16027

Cited by 5 publications

(2 citation statements)

References 48 publications

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“…The typical clinical features of ZIKV infection are relatively nonspecific, and only 20% to 25% of subjects infected with ZIKV have symptoms, making it difficult to detect or diagnose infection. 2,14,[34][35][36][37][38] Furthermore, ZIKV infection can occur concomitantly with other infections, making it more difficult to identify. The incubation period of ZIKV is 3 to 12 days, and the disease is often mild and self-limited, with symptoms usually resolving within 7 days.…”

Section: Zikv-induced Clinical Manifestationsmentioning

confidence: 99%

Zika virus: An emerging infectious disease with serious perinatal and neurologic complications

Casale

Teng

Morano

et al. 2018

Journal of Allergy and Clinical Immunology

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Zika virus (ZIKV) is a flavivirus that is primarily transmitted by Aedes aegypti, the mosquito vector also important in transmission of the flaviviruses responsible for dengue fever, yellow fever, and chikungunya. Because of occurrence in the same geographic regions, serologic cross-reactivity, and similar but often less severe clinical manifestations, such as dengue and chikungunya infections, ZIKV infection likely has gone undetected, misdiagnosed, or both for many years. ZIKV is somewhat unique among flaviviruses in its ability to also be transmitted through sexual contact, nonsexual body fluids, and perinatally. The relatively recent detection of the link between ZIKV infection and Guillain-Barré syndrome and fetal neurological defects, including microcephaly, has prompted intense efforts aimed at the development of new and specific diagnostic tests. Infection with ZIKV has been postulated to lead to a more severe clinical course from other structurally related viruses, especially dengue, and vice versa because of a phenomenon termed antibody-dependent enhancement. Inactivated whole virus, DNA, RNA, and vectored vaccine approaches to prevent ZIKV infection are in development, as are treatments for active disease that are safe in pregnant women. Here we summarize the important epidemiologic and clinical features of ZIKV infection, as well as the progress and challenges in developing rapid point-of-care diagnostic tests and vaccines to prevent disease. We used electronic databases to identify relevant published data regarding ZIKV MeSH searches.

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Section: Zikv-induced Clinical Manifestationsmentioning

confidence: 99%

Zika virus: An emerging infectious disease with serious perinatal and neurologic complications

Casale

Teng

Morano

et al. 2018

Journal of Allergy and Clinical Immunology

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“…Serial ultrasounds should be considered to monitor fetal anatomy and growth every three to four weeks in pregnant woman with laboratory evidence of ZIKV [14]. Serological tests and RT-PCR assays are recommended in infants whose mothers have had a risk of ZIKV exposure during pregnancy [55]. Further scientific studies are necessary for the prevention and control of ZIKV-related adverse outcomes.…”

Section: Management Prevention and Suggestionsmentioning

confidence: 99%

Zika Virus Infection and Microcephaly: Evidence for a Causal Link

Wang

Feng

2016

IJERPH

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Zika virus (ZIKV) is a flavivirus related to the Dengue, yellow fever and West Nile viruses. Since the explosive outbreaks of ZIKV in Latin America in 2015, a sudden increase in the number of microcephaly cases has been observed in infants of women who were pregnant when they contracted the virus. The severity of this condition raises grave concerns, and extensive studies on the possible link between ZIKV infection and microcephaly have been conducted. There is substantial evidence suggesting that there is a causal link between ZIKV and microcephaly, however, future studies are warranted to solidify this association. To summarize the most recent evidence on this issue and provide perspectives for future studies, we reviewed the literature to identify existing evidence of the causal link between ZIKV infection and microcephaly within research related to the epidemics, laboratory diagnosis, and possible mechanisms.

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TORCH Infections

2017

Diagnostic Imaging: Pediatrics

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Zika virus: A primer for clinicians

Cited by 5 publications

References 48 publications

Zika virus: An emerging infectious disease with serious perinatal and neurologic complications

Zika virus: An emerging infectious disease with serious perinatal and neurologic complications

Zika Virus Infection and Microcephaly: Evidence for a Causal Link

TORCH Infections

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