Zika virus and assisted reproduction

Cordeiro, Christina N.; Bano, Rashda; Cross, Chantel I.; Segars, James H.

doi:10.1097/gco.0000000000000366

Cited by 12 publications

(7 citation statements)

References 21 publications

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“…Regarding oocytes, there is only one case reporting the presence of ZIKV to date [83], and it is unknown if they will be susceptible to lasting ZIKV infection. Since there is no rapid test available for ZIKV IgM and IgG for semen sample, neither a standardized method to test human oocytes or embryos derived from women who underwent oocyte retrieval at a time of a positive serum ZIKV PCR result [84], the presence of ZIKV in semen and potentially in the female genital tract [85,86] must be taken into account when reviewing all protocols used in ART.…”

Section: Zikv and Assisted Reproductive Technologiesmentioning

confidence: 99%

An update on the aspects of Zika virus infection on male reproductive system

Borges

Vireque

Berteli

et al. 2019

J Assist Reprod Genet

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Zika virus (ZIKV) is mainly transmitted through Aedes mosquito bites, but sexual and post-transfusion transmissions have been reported. During acute infection, ZIKV is detectable in most organs and body fluids including human semen. Although it is not currently epidemic, there is a concern that the virus can still reemerge since the male genital tract might harbor persistent reservoirs that could facilitate viral transmission over extended periods, raising concerns among public health and assisted reproductive technologies (ART) experts and professionals. So far, the consensus is that ZIKV infection in the testes or epididymis might affect sperm development and, consequently, male fertility. Still, diagnostic tests have not yet been adapted to resource-restricted countries. This manuscript provides an updated overview of the cellular and molecular mechanisms of ZIKV infection and reviews data on ZIKV persistence in semen and associated risks to the male reproductive system described in human and animal models studies. We provide an updated summary of the impact of the recent ZIKVoutbreak on human-ART, weighing on current recommendations and diagnostic approaches, both available and prospective, with special emphasis on mass spectrometry-based biomarker discovery. In the light of the identified gaps in our accumulated knowledge on the subject, we highlight the importance for couples seeking ART to follow the constantly revised guidelines and the need of specific ZIKV diagnosis tools for semen screening to contain ZIKV virus spread and make ART safer.

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Section: Zikv and Assisted Reproductive Technologiesmentioning

confidence: 99%

An update on the aspects of Zika virus infection on male reproductive system

Borges

Vireque

Berteli

et al. 2019

J Assist Reprod Genet

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Section: Viral Evolution Likely Contributed To Pathogenicitymentioning

confidence: 99%

“…Zika’s unique ability to transfer directly between humans also suggests increased stability in bodily fluids, which may contribute to disease severity [ 25 , 61 ]. Cryogenic electron-microscopy of Zika incubated at different temperatures suggests high stability of viral particles at 40 °C in urine, saliva, or semen, in contrast to Dengue, which is not detected in these bodily fluids [ 61 , 62 , 63 , 64 , 65 ]. However, when studying the infectivity of Zika after incubation at 40 °C, the half-life (11.8 h) was comparable to Dengue (5.2 h) and West Nile virus (17.7 h), suggesting that viral pathogenicity is not only related to stability [ 62 , 66 ].…”

Section: Viral Evolution Likely Contributed To Pathogenicitymentioning

confidence: 99%

Causes of Phenotypic Variability and Disabilities after Prenatal Viral Infections

Kousa

Hossain

2021

TropicalMed

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Prenatal viral infection can lead to a spectrum of neurodevelopmental disabilities or fetal demise. These can include microencephaly, global developmental delay, intellectual disability, refractory epilepsy, deafness, retinal defects, and cortical-visual impairment. Each of these clinical conditions can occur on a semi-quantitative to continuous spectrum, from mild to severe disease, and often as a collective of phenotypes. Such serious outcomes result from viruses’ overlapping neuropathology and hosts’ common neuronal and gene regulatory response to infections. The etiology of variability in clinical outcomes is not yet clear, but it may be related to viral, host, vector, and/or environmental risk and protective factors that likely interact in multiple ways. In this perspective of the literature, we work toward understanding the causes of phenotypic variability after prenatal viral infections by highlighting key aspects of the viral lifecycle that can affect human disease, with special attention to the 2015 Zika pandemic. Therefore, this work offers important insights into how viral infections and environmental teratogens affect the prenatal brain, toward our ultimate goal of preventing neurodevelopmental disabilities.

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“…Zika virus (ZIKV) is an enveloped, single stranded, positive sense RNA virus from the family Flaviviridae. It is an arthropod-borne virus spread through Aedes aegypti and Aedes albopictus mosquitoes and also transmitted through bodily fluids [1][2][3] . It is the only flavivirus known to cause teratogenic effects in humans, primarily resulting in abnormally small head circumference-microcephaly, intracranial calcification, and fetal death in some cases.…”

Section: Introductionmentioning

confidence: 99%

Zika virus E protein alters blood-brain barrier by modulating brain microvascular endothelial cell and astrocyte functions

Kaur¹,

Pant²,

Bhagat³

et al. 2023

Preprint

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Neurotropic viruses can cross the otherwise dynamically regulated blood-brain barrier (BBB) and affect the brain cells. Zika virus (ZIKV) is an enveloped neurotropic Flavivirus known to cause severe neurological complications, such as encephalitis and foetal microcephaly. In the present study, we used human brain microvascular endothelial cells (hBMECs) and human progenitor derived astrocytes to form a physiologically relevant BBB model. We used this model to investigate the effects of ZIKV envelope (E) protein on properties of cells comprising the BBB. E protein is the principal viral protein involved in interaction with host cell surface receptors, facilitating the viral entry. Our findings show that ZIKV E protein results in activation of both hBMECs and astrocytes. hBMECs showed reduced expression of endothelial junction proteins - ZO-1, Occludin and VE-Cadherin, which are crucial in establishing and maintaining the BBB. As a result, ZIKV E protein triggered alteration in BBB integrity and permeability. We also found upregulation of genes involved in leukocyte recruitment along with increased proinflammatory chemokines and cytokines upon exposure to E protein. Furthermore, E protein resulted in astrogliosis as seen by increased expression of GFAP and Vimentin. Both BBB cell types exhibited inflammatory response following exposure to E protein which may influence viral access into the central nervous system (CNS), resulting in infection of other CNS cells. Overall, our study provides valuable insights into the transient changes that occur at the site of BBB upon ZIKV infection.

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Zika virus and assisted reproduction

Cited by 12 publications

References 21 publications

An update on the aspects of Zika virus infection on male reproductive system

An update on the aspects of Zika virus infection on male reproductive system

Causes of Phenotypic Variability and Disabilities after Prenatal Viral Infections

Zika virus E protein alters blood-brain barrier by modulating brain microvascular endothelial cell and astrocyte functions

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