Zika virus and HIV co-infection in five patients from two areas of Colombia

Villamil-Gómez, Wilmer E.; Sánchez-Herrera, Álvaro Rosendo; Hernández-Prado, Hugo; Hernández-Iriarte, Jayder; Díaz-Ricardo, Kelly; Serpa, Oscar Vicente Vergara; Castellanos, Jaime E.; Portela-Gaviria, J.E.; Patiño-Valencia, Sarita; Vargas-Bedoya, Dana C.; Orozco-Villa, Andrés F.; Reyes-Guerrero, S.S.; Castrillón-Spitia, Juan Daniel; Murillo-García, David R.; Henao-SanMartin, Valentina; Londoño, José J.; Bedoya-Rendón, Hector D.; Cárdenas-Pérez, Javier de Jesús; Cardona-Ospina, Jaime A.; Lagos-Grisales, Guillermo J.; Rodríguez‐Morales, Alfonso J.

doi:10.1016/j.jfma.2018.05.019

Cited by 5 publications

(1 citation statement)

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“…22 34 38 Further, one ZIKV/HIV-coinfected case developed sepsis, resulting in death. 34 Two ZIKV/Leptospira spp-coinfected cases developed haemodynamic instability, one resulting in septic shock,and one in death. 39 40 Additionally, one ZIKV/Schistosma mansoni-coinfected case experienced testicular inflammation with granulomas induced by schistosome eggs.…”

Section: Zikv/chikv Coinfectionsmentioning

confidence: 99%

The frequency and clinical presentation of Zika virus coinfections: a systematic review

et al. 2020

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BackgroundThere is limited knowledge on the influence of concurrent coinfections on the clinical presentation of Zika virus (ZIKV) disease.MethodsTo better understand the types, frequencies and clinical manifestations of ZIKV coinfections, we did a systematic review of four databases (PubMed, Embase, Web of Science, LILACS) without restrictions for studies on ZIKV coinfections confirmed by nucleic acid (quantitative real-time-PCR) testing of ZIKV and coinfecting pathogens. The review aimed to identify cohort, cross-sectional, case series and case report studies that described frequencies and/or clinical signs and symptoms of ZIKV coinfections. Conference abstracts, reviews, commentaries and studies with imprecise pathogen diagnoses and/or no clinical evaluations were excluded.ResultsThe search identified 34 articles from 10 countries, comprising 2 cohort, 10 cross-sectional, 8 case series and 14 case report studies. Coinfections were most frequently reported to have occurred with other arthropod-borne viruses (arboviruses); out of the 213 coinfections described, ZIKV infections co-occurred with chikungunya in 115 cases, with dengue in 68 cases and with both viruses in 19 cases. Other coinfecting agents included human immunodeficiency, Epstein-Barr, human herpes and Mayaro viruses, Leptospira spp, Toxoplasma gondii and Schistosoma mansoni. ZIKV-coinfected cases primarily presented with mild clinical features, typical of ZIKV monoinfection; however, 9% of cases in cohort and cross-sectional studies were reported to experience complications.ConclusionBased on the evidence collated in this review, coinfections do not appear to strongly influence the clinical manifestations of uncomplicated ZIKV infections. Further research is needed to confirm whether risk of severe complications is altered when ZIKV infection co-occurs with other infections.PROSPERO registration numberCRD42018111023.

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Section: Zikv/chikv Coinfectionsmentioning

confidence: 99%