Zika virus detected in amniotic fluid and umbilical cord blood in an in vitro fertilization-conceived pregnancy in Venezuela

Benjamin, Isaac; Fernández, Gissel; Figueira, José Valentin; Parpacén, Leticia; Urbina, María Teresa; Medina, Rubén Danilo Méndez

doi:10.1016/j.fertnstert.2017.02.112

Cited by 17 publications

(16 citation statements)

References 8 publications

(6 reference statements)

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“…However, there are nucleic acid and serology tests that are authorized to screen blood donor and patient samples . As ZIKV can persist in the placental tissue and UCB long after the mother has cleared the active infection in her plasma, the most recent ZIKV guidance update from the FDA does not recommend testing the mother for donor eligibility.…”

Section: Ucb Regulation and Zikv Screeningmentioning

confidence: 99%

Zika virus and its implications on cord blood banking and transplantation

Stone

Shaz

2020

Transfusion

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KEY IDEAS Umbilical cord blood is an important cellular therapy product used for hematopoietic stem cell transplantation, but the US Food and Drug Administration guidance regarding donor screening to reduce the risk of Zika transmission has decreased the number of licensed, eligible cord blood units available for transplantation. There is a crucial need for updated travel risk assessment for Zika virus transmission, validated screening tests for Zika virus in umbilical cord blood, and further research on Zika virus transmissibility due to umbilical cord blood products to ensure that umbilical cord blood and related tissues are safe and available for transplantation.

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Section: Ucb Regulation and Zikv Screeningmentioning

confidence: 99%

Zika virus and its implications on cord blood banking and transplantation

Stone

Shaz

2020

Transfusion

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“…The optimal timing for amniocentesis is also not established. Small case series describe the timing of amniocentesis based on empiric estimates derived from the CMV literature -That is, at least 6 weeks post infection, and at least 21 weeks gestation (Shaub et al, 2017), although there are reports of positive amniotic fluid PCR from earlier gestations (Benjamin et al, 2017). It also appears that Zika RNA may not always be detected throughout the entire duration of pregnancy.…”

Section: Reviewmentioning

confidence: 99%

Zika Virus Infection and Implications for Reproduction

Giles

Cole

2019

FandR

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Zika virus infection during pregnancy can have devastating effects on the foetus leading to congenital Zika syndrome. It is relevant therefore for couples living in countries with endemic Zika virus to understand the strategies they can utilise to reduce the chance of infection. In addition, couples planning pregnancy, or who are already pregnant, travelling to countries with Zika virus need to be informed of the potential risk and implications for future reproductive planning.

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“…ZIKV has been detected in blood (Jurado and Iwasaki 2017), saliva (Barzon et al 2016), urine (Gourinat et al 2015;Zhang et al 2016), fetal brain (Oliveira Melo et al 2016), and semen (Mansuy et al 2016;Counotte et al 2018), in cases of renal transplantation (Nogueira et al 2017) and in amniotic fluid (Calvet et al 2016;Benjamin et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Detection of Zika virus in paired urine and amniotic fluid samples from symptomatic and asymptomatic women and their babies during a disease outbreak: association with neurological symptoms in newborns

et al. 2019

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Paired maternal and newborn urine and amniotic fluid from 138 subjects collected during a Zika virus (ZIKV) outbreak was analyzed for ZIKV by gene amplification (RT-qPCR), and the findings were correlated with clinical symptoms and neurological anomalies in the babies. ZIKV was detected in 1 of 9 symptomatic women (11.1%) and in 19 of 129 asymptomatic women (14.7%). Neurological manifestations were present in 19 babies (13.7%), 10 of 20 (50%) positive and 9 of 119 (7.6%) negative (p < 0.001) for ZIKV. Twelve (8.6%) urines collected during gestation were ZIKV-positive; only 2 remained positive for ZIKV postpartum. Six (4.1%) newborn urines collected within 1 day of delivery were ZIKV-positive cases. In 3 of these cases, ZIKV was detected in mother's urine pre-and postpartum and in both mother's urine and babies' urine. Four of the amniotic fluid samples (2.9%) were ZIKV-positive. Among ZIKV-negative babies with neurological sequel, 87.5% were female; in contrast, 72.7% ZIKV-positive babies with neurological abnormalities were male (p = 0.019). We conclude that during a ZIKVoutbreak, clinical symptoms and ZIKV detection in biological fluids are poor predictors of infection and adverse neurologic sequel in newborns.

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Zika virus detected in amniotic fluid and umbilical cord blood in an in vitro fertilization-conceived pregnancy in Venezuela

Cited by 17 publications

References 8 publications

Zika virus and its implications on cord blood banking and transplantation

Zika virus and its implications on cord blood banking and transplantation

Zika Virus Infection and Implications for Reproduction

Detection of Zika virus in paired urine and amniotic fluid samples from symptomatic and asymptomatic women and their babies during a disease outbreak: association with neurological symptoms in newborns

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