Zika virus disease for neurologists

Smith, Daniel; Beckham, J. David; Tyler, Kenneth L.; Pastula, Daniel M.

doi:10.1212/cpj.0000000000000307

Cited by 13 publications

(4 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While ZIKV infection of adults generally produces only a mild disease, it is becoming apparent that, as with other flavivirus infections, severe neurological sequelae can occur. Recent outbreaks have been associated with higher incidences of peripheral neuropathies such as Guillian-Barrë syndrome (GBS) (Brasil et al 2016 ; Cao-Lormeau et al 2016 ; Cardoso et al 2015 ; Samarasekera and Triunfol 2016 ) and other neurological diseases such as myelitis (Anaya et al 2017 ; Dirlikov et al 2016 ; Mecharles et al 2016 ), encephalitis (Carteaux et al 2016 ; Nicastri et al 2016 ; Soares et al 2016 ), seizures (Asadi-Pooya 2016 ), and various ophthalmological conditions (Pastula et al 2016 ; Smith et al 2016 ). This is not surprising considering that related flaviviruses such as West Nile virus (WNV) and Japanese encephalitis virus (Solomon et al 1998 ) can cause myelitis and motor deficits (Sejvar et al 2003 ).…”

Section: Introductionmentioning

confidence: 99%

Zika virus-induced acute myelitis and motor deficits in adult interferon αβ/γ receptor knockout mice

et al. 2018

View full text Add to dashboard Cite

Zika virus (ZIKV) has received widespread attention because of its effect on the developing fetus. It is becoming apparent, however, that severe neurological sequelae, such as Guillian-Barrë syndrome (GBS), myelitis, encephalitis, and seizures can occur after infection of adults. This study demonstrates that a contemporary strain of ZIKV can widely infect astrocytes and neurons in the brain and spinal cord of adult, interferon α/β receptor knockout mice (AG129 strain) and cause progressive hindlimb paralysis, as well as severe seizure-like activity during the acute phase of disease. The severity of hindlimb motor deficits correlated with increased numbers of ZIKV-infected lumbosacral spinal motor neurons and decreased numbers of spinal motor neurons. Electrophysiological compound muscle action potential (CMAP) amplitudes in response to stimulation of the lumbosacral spinal cord were reduced when obvious motor deficits were present. ZIKV immunoreactivity was high, intense, and obvious in tissue sections of the brain and spinal cord. Infection in the brain and spinal cord was also associated with astrogliosis as well as T cell and neutrophil infiltration. CMAP and histological analysis indicated that peripheral nerve and muscle functions were intact. Consequently, motor deficits in these circumstances appear to be primarily due to myelitis and possibly encephalitis as opposed to a peripheral neuropathy or a GBS-like syndrome. Thus, acute ZIKV infection of adult AG129 mice may be a useful model for ZIKV-induced myelitis, encephalitis, and seizure activity.Electronic supplementary materialThe online version of this article (10.1007/s13365-017-0595-z) contains supplementary material, which is available to authorized users.

show abstract

Section: Introductionmentioning

confidence: 99%

Zika virus-induced acute myelitis and motor deficits in adult interferon αβ/γ receptor knockout mice

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Authors have noted that, from human, first this virus was isolated along with pyrexia as clinical manifestation observed by Simpson and coworkers in 1964 [2] . The development of neurological disturbances shows in stage of infancy because at the time of pregnancy, mother has affected by mosquito borne Zika virus (ZIKV) [3] . At first, the ZIKV was observed from Yap Island in Micronesia [4] .…”

Section: Introductionmentioning

confidence: 99%

Therapeutic nutrition against Zika virus infection: An update

Banerjee,

Pramanik,

Mukherjee

et al. 2024

Int. J. Mosq. Res.

View full text Add to dashboard Cite

Zika virus is the mosquito-borne Flavivirus which may develop Zika syndrome, it develops psychiatric illness, featured through microcephaly along with mental complication and even also death of foetus. First Zika virus is recognised from mosquito species Aedes africanus in the Ziika forest of Uganda. In general, ZIKV are very much prominent among affected healthy children and adults by skin rashes along with trouble in joints, conjunctivitis, malaise, headache that are present for 2 to 7 days. In case of pregnant women, complications of this virus are congenital brain disorder and ocular imperfection in foetus, faultiness of brain including microcephaly besides ocular obstruction like microphthalmia, weakness in optic nerve, cataracts are also recognised. Some bioactive constituent like nutraceuticals have immense effect to protect human from Zika virus manifestation including Brazilian peppertree fruit peel extract, isoquercitrin, curcumin, Docosahexaenoic acid (DHA) and soon.

show abstract

“…The first human case was reported during the isolation process of the virus, wherein the clinical signs were described as pyrexia along with rashes by Simpson et al in 1964 [ 3 ]. The occurrence of neurological abnormalities in infants born to pregnant mothers infected with ZIKV created concern regarding disease outbreak [ 4 ]. Currently, there is no Food and Drug Administration (FDA) approved vaccine or treatment for ZIKV infection.…”

Section: Introductionmentioning

confidence: 99%

Novel Therapeutic Nutrients Molecules That Protect against Zika Virus Infection with a Special Note on Palmitoleate

et al. 2022

View full text Add to dashboard Cite

Zika virus (ZIKV) is a Flavivirus from the Flaviviridae family and a positive-sense single strand RNA virus. ZIKV infection can cause a mild infection to the mother but can be vertically transmitted to the developing fetus, causing congenital anomalies. The prevalence of ZIKV infections was relatively insignificant with sporadic outbreaks in the Asian and African continents until 2006. However, recent epidemic in the Caribbean showed significant increased incidence of Congenital Zika Syndrome. ZIKV infection results in placental pathology which plays a crucial role in disease transmission from mother to fetus. Currently, there is no Food and Drug Administration (FDA) approved vaccine or therapeutic drug against ZIKV. This review article summarizes the recent advances on ZIKV transmission and diagnosis and reviews nutraceuticals which can protect against the ZIKV infection. Further, we have reviewed recent advances related to the novel therapeutic nutrient molecules that have been shown to possess activity against Zika virus infected cells. We also review the mechanism of ZIKV-induced endoplasmic reticulum and apoptosis and the protective role of palmitoleate (nutrient molecule) against ZIKV-induced ER stress and apoptosis in the placental trophoblasts.

show abstract

Zika virus disease for neurologists

Cited by 13 publications

References 48 publications

Zika virus-induced acute myelitis and motor deficits in adult interferon αβ/γ receptor knockout mice

Zika virus-induced acute myelitis and motor deficits in adult interferon αβ/γ receptor knockout mice

Therapeutic nutrition against Zika virus infection: An update

Novel Therapeutic Nutrients Molecules That Protect against Zika Virus Infection with a Special Note on Palmitoleate

Contact Info

Product

Resources

About