Zika virus-induced neurological critical illness in Latin America: Severe Guillain-Barre Syndrome and encephalitis

Sebastián, Ugarte Ubiergo; Ricardo, Arenas Villamizar Angel; Alvarez, Bruno; Cubides, Angela; Luna, Angélica F.; Arroyo-Parejo, Max; Acuña, Cayri E.; Quintero, Agamenón V.; Villareal, Orlando Ch.; Pinillos, Oscar S.; Vieda, Elías; Bello, Manuel Bellido; Peña, Susana Patricia Collado; Dueñas, Carmelo; Rodriguez, Gloria M.V.; Ranero, Jorge L.M.; López, Ricardo Calvo; Olaya, Sandra; Vergara, José; Tandazo, Ana; Ospina, Juan P.S.; Soto, I Martínez; Fowler, Robert; Marshall, John C.

doi:10.1016/j.jcrc.2017.07.038

Cited by 35 publications

(24 citation statements)

References 30 publications

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“…Extensive research has revealed that ZIKV has a wide tissue tropism and can cross the placental barrier of pregnant women, thus interfering with proper neurological development in the fetus (6)(7)(8). ZIKV has also been found to cause neuroinflammatory disorders in a fraction of otherwise healthy adults and children (9,10). Amongst the most worrying features of ZIKV is perhaps the fact that infectious virus may persist in the testis and the virus may therefore be transmitted sexually (11).…”

Section: Introductionmentioning

confidence: 99%

Effector CD8 T Cell-Dependent Zika Virus Control in the CNS: A Matter of Time and Numbers

et al. 2020

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Zika virus (ZIKV), a mosquito-borne flavivirus, came into the spotlight in 2016 when it was found to be associated with an increased rate of microcephalic newborns in Brazil. The virus has further been recognized to cause neurologic complications in children and adults in the form of myelitis, encephalitis, acute disseminated encephalomyelitis (ADEM) and Guillain Barre Syndrome in a fraction of infected individuals. With the ultimate goal of identifying correlates of protection to guide the design of an effective vaccine, the study of the immune response to ZIKV infection has become the focus of research worldwide. Both innate and adaptive immune responses seem to be essential for controlling the infection. Induction of sufficient levels of neutralizing antibodies has been strongly correlated with protection against reinfection in various models, while the role of CD8 T cells as antiviral effectors in the CNS has been controversial. In an attempt to improve our understanding regarding the role of ZIKV-induced CD8 T cells in protective immunity inside the CNS, we have expanded on previous studies in intracranially infected mice. In a recent study, we have demonstrated that, peripheral ZIKV infection in adult C57BL/6 mice induces a robust CD8 T cell response that peaks within a week. In the present study, we used B cell deficient as well as wild-type mice to show that there is a race between CXCR3-dependent recruitment of the effector CD8 T cells and local ZIKV replication, and that CD8 T cells are capable of local viral control if they arrive in the brain early after viral invasion, in appropriate numbers and differentiation state. Our data highlight the benefits of considering this subset when designing vaccines against Zika virus.

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Section: Introductionmentioning

confidence: 99%

Effector CD8 T Cell-Dependent Zika Virus Control in the CNS: A Matter of Time and Numbers

et al. 2020

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“…In Colombia, previous studies completed during the ZIKV epidemic have reported cases of encephalitis and myelitis in adults (Sebastian et al, 2017). Recently, published data from the Instituto Nacional de Salud of Colombia describing ZIKV-associated illness in the pediatric population during the epidemic, reported 96 hospitalizations for ZIKV-associated neurological illnesses.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, prenatal infection-especially early in gestation-has been associated with congenital Zika syndrome, which is characterized by microcephaly and encephalic and ocular alterations (de Paula Freitas et al, 2016;Rasmussen et al, 2016). Although Guillain-Barré syndrome is the most frequently observed neurological complication of postnatal ZIKV infection, other neurological diseases such as meningoencephalitis, encephalitis, and myelitis-some of which have proved fatal-have been reported in adults and travelers to endemic areas (Roze et al, 2016;Schwartzmann et al, 2017;Sebastian et al, 2017;Soares et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Clinical, laboratory and immune aspects of Zika virus-associated encephalitis in children

Salgado

Vega

Rodríguez

et al. 2020

International Journal of Infectious Diseases

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To evaluate the clinical, laboratory, and immune characteristics of Zika virus (ZIKV)-associated encephalitis in pediatric patients after the epidemic in Huila, southern Colombia. Methods: A pediatric neuro-surveillance hospital study was conducted in a referral health center in southern Colombia, from October 2016 to October 2017. Cases of encephalitis were confirmed by nucleic acid amplification tests and serological methods in cerebrospinal fluid (CSF), plasma, and/or urine. Levels of six cytokines were evaluated by flow cytometry. Patients underwent daily clinical and laboratory follow-up. Results: Twenty children with probable encephalitis were included for further studies and 16 of them were confirmed. Four cases of bacterial meningoencephalitis (Streptococcus pneumoniae, group B Streptococcus, Staphylococcus epidermidis, and Escherichia coli) and 12 cases of viral encephalitis were identified, six of them associated with ZIKV infection. Other viral encephalitis cases were caused by herpes viruses (n = 3), enterovirus (n = 2), and dengue virus type 2 (DENV-2; n = 1) infections. ZIKVassociated encephalitis symptoms subsided faster than those of patients with encephalitis caused by other agents. CSF analysis revealed lymphocytic pleocytosis. Compared to healthy controls, children with ZIKV-associated encephalitis presented modest plasma interleukin (IL)-10 but not IL-2, IL-4, IL-6, interferon gamma (IFN-g), or tumor necrosis factor alpha (TNF-α). Cytokine expression was differentially regulated, as dramatically elevated IL-6, IL-10, and IFN-g levels were observed in CSF but not in paired plasma samples in one of the patients with ZIKV detectable in CSF. Conclusions: This study provides evidence that ZIKV is responsible for pediatric encephalitis in endemic areas, and the local presence of the virus may induce cephalic but not systemic expression of cytokines.

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“…(Krauer et al 2017, Yepez et al 2017, Medina and Medina-Montoya 2017, Peña et al 2019. Findings from these studies described some of the developmental abnormalities in children born to mothers that were infected with Zika during pregnancy (Sebastian et al 2017, Rice et al 2018, Gely-Rojas et al 2018, Ochoa et al 2019, Mulkey et al 2019, Santos-Antonio et al 2019. Most important, patient cohorts that were born during this epidemic are being followed in longitudinal studies to determine the long-term effects of Zika infection (Cortes et al 2018, Wilder-Smith et al 2019.…”

Section: Health Issuesmentioning

confidence: 99%

Developmental Biology in Central America, the northern region of South America and the Caribbean

García‐Arrarás

2021

Int. J. Dev. Biol.

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This review highlights the history of Developmental Biology studies in Latin-American countries of Central America, the northern region of South America and the Caribbean and their impact on the field. For this, we have compiled the contributions made by investigators in various institutions of the region, including universities, agricultural, research and health centers. Most of the contributions focus on particular fields, among them, Evo-Devo, regenerative biology, nervous system development and health related issues. A large share of the contributions originates from a subset of countries, primarily, Colombia, Costa Rica, Ecuador, Panama and Puerto Rico. In addition, we underscore the new investigators and the ongoing research in the region.

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Zika virus-induced neurological critical illness in Latin America: Severe Guillain-Barre Syndrome and encephalitis

Cited by 35 publications

References 30 publications

Effector CD8 T Cell-Dependent Zika Virus Control in the CNS: A Matter of Time and Numbers

Effector CD8 T Cell-Dependent Zika Virus Control in the CNS: A Matter of Time and Numbers

Clinical, laboratory and immune aspects of Zika virus-associated encephalitis in children

Developmental Biology in Central America, the northern region of South America and the Caribbean

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