Zika Virus Infection during Pregnancy and Sensorineural Hearing Loss among Children at 3 and 24 Months Post-Partum

Fandiño-Cárdenas, Marcela; Idrovo, Álvaro J.; Velandia, Roman; Molina-Franky, Jessica; Alvarado-Socarrás, Jorge L.

doi:10.1093/tropej/fmy055

Cited by 22 publications

(35 citation statements)

References 23 publications

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“…These results are consistent with other reports. 13,14,28,29 Leite et al 29 performed hearing tests in 45 children born to mothers with evidence of ZIKV infection not necessarily presenting microcephaly. The authors also report a few cases suggesting middle ear pathology, but no evidence of sensorineural hearing loss, and stated that middle ear effusion is a remarkable finding in young children.…”

Section: Discussionmentioning

confidence: 99%

“…Fandiño-Cárdenas et al 14 performed hearing tests in children prenatally exposed to the ZIKV, including children with and without microcephaly. The evaluation included OAE, tympanometry, and ABR assessments at 3 and 24 months of age, with no significant alterations found in any of the situations.…”

Section: Discussionmentioning

confidence: 99%

“… 10 Based on existing reports, a trend to include children with congenital ZIKV infection in this group is noted. 2 11 12 13 14 Furthermore, it is recommended that children in the risk group are followed-up by developmental milestone surveillance, hearing abilities, and middle ear conditions. At least one audiological evaluation should be performed between 24 and 30 months of age, due to the risk of progressive or late onset hearing loss.…”

Section: Introductionmentioning

confidence: 99%

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Normal Hearing Function in Children Prenatally Exposed to Zika Virus

Barbosa

Garcia

Magalhães‐Barbosa

et al. 2019

Int Arch Otorhinolaryngol

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Introduction The association between prenatal Zika virus infection and hearing alterations in offspring has been the object of some studies, although few have assessed children without microcephaly. However, a current trend to include prenatal Zika virus exposure in the group of risk indicators for hearing loss is noted. Objective To present a series of 27 children prenatally exposed to the Zika virus submitted to multiple hearing assessments over time. Methods A cohort of children born to symptomatic mothers with laboratorial Zika virus infection confirmation during pregnancy was submitted to an otoacoustic emission test, auditory brainstem response test (automated, neurodiagnostic and frequency-specific), audiometry, and imitanciometry over a period of 36 months since birth. The hearing assessment was performed independently of the presence of microcephaly or other apparent signs of congenital Zika syndrome. Results The hearing tests presented predominantly normal results. Some children had signs of middle ear pathology. The only microcephalic child had normal electrophysiological tests, as well as preserved audiometric thresholds, but presented altered motor responses to sound. Conclusion Prenatal exposure to Zika virus does not always determine hearing impairment. This risk seems to be more associated to the severity of the central nervous system damage. Hearing screening and follow-ups of the affected children are important, as well as further research in this area.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Normal Hearing Function in Children Prenatally Exposed to Zika Virus

Barbosa

Garcia

Magalhães‐Barbosa

et al. 2019

Int Arch Otorhinolaryngol

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“…This mosquito-borne pathogen is able to pass through the placental barrier to infect the fetus and create developmental problems ( Almeida et al, 2020 ; Cugola et al, 2016 ). The incidence of birth defects is difficult to assess with lack of access to the RT-PCR equipment necessary to rule out the infection in affected areas ( Barbosa et al, 2020 ; Fandino-Cardenas, Idrovo, Velandia, Molina-Franky, & Alvarado-Socarras, 2019 ; Leal, Muniz, Caldas Neto, van der Linden, & Ramos, 2020 ). This problem could explain the wide range of hearing deficits assessed in different studies, which range from 0% to 68% of infected fetuses ( Barbosa et al, 2020 ; Fandino-Cardenas et al, 2019 ; Satterfield-Nash et al, 2017 ).…”

Section: Environmental Causes Of Congenital Hearing Lossmentioning

confidence: 99%

Congenital Deafness and Recent Advances Towards Restoring Hearing Loss

Renauld

Basch

2021

Current Protocols

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Congenital hearing loss is the most common birth defect, estimated to affect 2‐3 in every 1000 births. Currently there is no cure for hearing loss. Treatment options are limited to hearing aids for mild and moderate cases, and cochlear implants for severe and profound hearing loss. Here we provide a literature overview of the environmental and genetic causes of congenital hearing loss, common animal models and methods used for hearing research, as well as recent advances towards developing therapies to treat congenital deafness. © 2021 The Authors.

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“…Though pregnancy itself is not a disorder, some undesirable changes may occur during pregnancy due to an altered physiological state, such as nausea, vomiting, edema, varicose veins, heartburn, constipation, backache, tiredness, loss of sleep, hypertension, diabetes, and abnormal bleeding (2)(3)(4). Presently, there is not enough information to know whether pregnant women have a higher risk of COVID-19-related illness, although pregnant women are at greater risk of non-COVID-19-associated respiratory infections (5)(6)(7)(8)(9). Also, the potential risk of COVID-19 positivity during pregnancy on maternal and fetal health needs carefully designed studies.…”

Section: Introductionmentioning

confidence: 99%