Zika virus infection followed by a first episode of psychosis: another flavivirus leading to pure psychiatric symptomatology

Corrêa-Oliveira, Gabriel Elias; Fonseca, Benedito Antônio Lopes da; Del-Ben, Cristina Marta

doi:10.1590/1516-4446-2017-2308

Cited by 14 publications

(8 citation statements)

References 5 publications

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“…Our findings predict that many of these individuals may have changes in their DNA methylome that could ultimately affect the expression of key genes involved in a spectrum of neuropsychiatric disorders. Our findings, together with recent clinical reports describing a causal relationship between ZIKV infection in adolescents and severe depression ( 31 ) and psychosis ( 32 ), support the hypothesis that ZIKV might directly trigger neuropsychiatric and cognitive disease. Hence, while more is being learned about the consequences of severe symptomatic ZIKV infection, our results reinforce the concern that asymptomatic prenatal ZIKV infections could have long-term effects on neurodevelopment, justifying further rigorous study to identify infected individuals and mechanisms of disease induction.…”

Section: Discussionsupporting

confidence: 87%

Zika Virus Alters DNA Methylation of Neural Genes in an Organoid Model of the Developing Human Brain

et al. 2018

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Scientific research on human neural stem cells and cerebral organoids has confirmed the congenital neurotropic and neurodestructive nature of the Zika virus. However, the extent to which prenatal ZIKV infection is associated with more subtle brain alterations, such as epigenetic changes, remains ill defined. Here, we address the question of whether ZIKV infection induces DNA methylation changes with the potential to cause brain disorders later in life.

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Section: Discussionsupporting

confidence: 87%

Zika Virus Alters DNA Methylation of Neural Genes in an Organoid Model of the Developing Human Brain

et al. 2018

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“…Many of the psychotic patients also had a diagnostic (four-fold) change in viral antibody titers over the 2-week study period, indicating active viral infection [ 11 ]. A number of case reports have been published describing persecutory delusions, poor self-care, vivid auditory and visual hallucinations, food refusal, and insomnia following infection with the mosquito-borne dengue virus and Zika virus [ 12 – 14 ]. Psychiatric complications associated with these two flaviviruses seem to follow a similar pattern with onset of psychosis occurring approximately 1 week after resolution of viral symptoms (e.g., fever, rash, myalgia) and excellent response to atypical antipsychotics.…”

Section: Discussionmentioning

confidence: 99%

COVID-19-Induced Psychosis and Suicidal Behavior: Case Report

Chacko

Job

Caston

et al. 2020

SN Compr. Clin. Med.

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The COVID-19 pandemic is associated with different types of stressors: fear of infection, financial burden, and social isolation. Additionally, COVID-19 infection seems to increase the risk for neuropsychiatric symptoms including psychosis. We present a case of a 52-year-old male with no previous psychiatric history who developed severe paranoia leading to a suicide attempt. He was successfully treated with a combination of milieu treatment, pharmacotherapy, and electroconvulsive therapy. We add to the nascent literature that COVID-19, as other coronaviruses, can increase the risk for severe psychosis and suicidal behavior.

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“…These organic risk factors-associated psychoses are common in Africa, especially among children and adolescents. Some infectious agents implicated as risk factors of psychosis include Chlamydia pneumoniae (Xavier et al, 2005), urinary tract infection (Carson et al, 2017), Zika virus (Corrêa-Oliveira et al, 2017) amongst others have been reported to increase the risk of psychosis. Maternal bacterial infection during pregnancy was also reported to increase the risk of neonatal psychotic disorders (Lee et al, 2019).…”

Section: Epidemiology Of Psychosismentioning

confidence: 99%

Cerebral Malaria and Toxoplasmosis: Could their Concomitant Presentation Worsen Psychotic Condition?

Ibrahim

Atilola

Mohammed

et al. 2020

Annals of Science and Technology

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Malaria and toxoplasmosis are two important parasitic diseases with significant public health concerns in the Sub-Saharan African countries. Some aspects of pathogenesis of the two parasitic diseases involve the central nervous system manifesting neuropsychiatric disorders. Studies have implicated the single infection by Plasmodium spp. and Toxoplasma gondii in development of psychosis. Although concomitant infection of the two parasites suggests an aggravated psychotic condition, there is currently no reported study. This article reviewed some studies which implicated malaria and toxoplasmosis in psychosis. It further explored the likely role of concurrent infection by the parasites on psychosis, the dynamics of their pathology and possible effects of certain psychosis-associated cytokines and other biomolecules on the central nervous system. We recommend evidence-based research efforts in this field for the effective management of these two parasitic diseases to abate the public health burden of psychosis.

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Zika virus infection followed by a first episode of psychosis: another flavivirus leading to pure psychiatric symptomatology

Cited by 14 publications

References 5 publications

Zika Virus Alters DNA Methylation of Neural Genes in an Organoid Model of the Developing Human Brain

Zika Virus Alters DNA Methylation of Neural Genes in an Organoid Model of the Developing Human Brain

COVID-19-Induced Psychosis and Suicidal Behavior: Case Report

Cerebral Malaria and Toxoplasmosis: Could their Concomitant Presentation Worsen Psychotic Condition?

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