Zika virus infection in children: epidemiology and clinical manifestations

Pone, Marcos Vinícius da Silva; Pone, Sheila Moura; Zin, Andréa; Mendes, Pedro Henrique Barros; Aibe, Mitsue Senra; Aguiar, Elisa Barroso de; Silva, Tallita de Oliveira Gomes da

doi:10.1007/s00381-017-3635-3

Cited by 26 publications

(17 citation statements)

References 62 publications

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“…Even though ZIKV infection in the second and third trimester of pregnancy seemed to be a lower risk compared to ZIKV infection in the first trimester, it is important to highlight that this infection carries a risk for the development of microcephaly and other adverse pregnancy outcomes throughout the full duration of pregnancy [4,46,47]. There is still a lack of knowledge on the magnitude of the risk of newborns infected by ZIKV developing microcephaly later in childhood [48,49].…”

Section: Discussionmentioning

confidence: 99%

Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis

et al. 2020

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Background: Although it is known that Zika virus (ZIKV) infection during pregnancy may lead to microcephaly in the fetus, the prognostic factors associated with this tragic disorder remain unclear. We conducted a systematic review and meta-analysis to assess the prognostic factors associated with the incidence of microcephaly in congenital ZIKV infection. Methods: We conducted a comprehensive search in Ovid MEDLINE, Ovid MEDLINE (R) Epub ahead of print, Embase, Embase Classic, Web of Science, CINAHL, Cochrane CENTRAL, LILACS, and various thesis databases to identify human studies reporting microcephaly associated with congenital ZIKV infection. We requested primary data from the authors of the included studies to calculate summary estimates and conduct the meta-analysis of the most prevalent factors. Results: We screened 4106 titles and abstracts, and identified 12 studies for inclusion in the systematic review. The assessment of ZIKV infection and the definition of microcephaly varied among studies. A total of 6154 newborns/ fetuses were enrolled; of those, 1120 (18.20%) had a diagnostic of ZIKV infection, of which 509 (45.45%) were diagnosed with microcephaly. Nine studies addressed the link between congenital ZIKV infection and neurological findings in newborns/fetuses. Half of the studies provided primary data. Three out of 11 factors of interest seem to be prognostic factors of microcephaly: infant's sexmales compared to females: Relative Risk (RR) 1.30, 95% Confidence Interval (95% CI) 1.14 to 1.49; the stage of pregnancy when infection occurredinfection in the first trimester of pregnancy compared to infection at other stages of pregnancy: RR 1.41, 95% CI 1.09 to 1.82; and asymptomatic infection compared to symptomatic infection during pregnancy: RR 0.68; 95% CI 0.60 to 0.77. Conclusion: Our findings support the female-biased resistance hypothesis and reinforce the risk associated with the stage of pregnancy when ZIKV infection occurs. Continued surveillance of ZIKV infection during pregnancy is needed to identify additional factors that could contribute to developing microcephaly in affected fetuses.

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Section: Discussionmentioning

confidence: 99%

Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis

et al. 2020

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“…Even though ZIKV infection in the second and third trimester of pregnancy seemed to be a lower risk compared to ZIKV infection in the rst trimester, it is important to highlight that this infection carries a risk for the development of microcephaly and other adverse pregnancy outcomes throughout the full duration of pregnancy [4,46,47]. There is still a lack of knowledge on the magnitude of the risk of newborns infected by ZIKV developing microcephaly later in childhood [48,49].…”

Section: Discussionmentioning

confidence: 99%

Another piece of the Zika puzzle: Assessing the associated factors to microcephaly in a systematic review and meta-analysis.

Gallo

Martínez-Cajas

Peixoto

et al. 2020

Preprint

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Background: Although it is known that Zika virus (ZIKV) infection during pregnancy may lead to microcephaly in the fetus, the prognostic factors associated with this tragic disorder remain unclear. We conducted a systematic review and meta-analysis to assess the prognostic factors associated with the incidence of microcephaly in congenital ZIKV infection. Methods: We conducted a comprehensive search in Ovid MEDLINE, Ovid MEDLINE (R) Epub ahead of print, Embase, Embase Classic, Web of Science, CINAHL, Cochrane CENTRAL, LILACS, and various thesis databases to identify human studies reporting microcephaly associated with congenital ZIKV infection. We requested primary data from the authors of the included studies to calculate summary estimates and conduct the meta-analysis of the most prevalent factors.Results: We screened 4106 titles and abstracts, and identified 12 studies for inclusion in the systematic review. The assessment of ZIKV infection and the definition of microcephaly varied among studies. A total of 6154 newborns/fetuses were enrolled; of those, 1120 (18.20%) had a diagnostic of ZIKV infection, of which 509 (45.45%) were diagnosed with microcephaly. Nine studies addressed the link between congenital ZIKV infection and neurological findings in newborns/fetuses. Half of the studies provided primary data. Three out of 11 factors of interest seem to be prognostic factors of microcephaly: infant’s sex – males compared to females: Relative Risk (RR) 1.30, 95% Confidence Interval (95% CI) 1.14 to 1.49; the stage of pregnancy when infection occurred – infection in the first trimester of pregnancy compared to infection at other stages of pregnancy: RR 1.41, 95% CI 1.09 to 1.82; and asymptomatic infection compared to symptomatic infection during pregnancy: RR 0.68; 95% CI 0.60 to 0.77.Conclusion: Our findings support the female-biased resistance hypothesis and reinforce the risk associated with the stage of pregnancy when ZIKV infection occurs. Continued surveillance of ZIKV infection during pregnancy is needed to identify additional factors that could contribute to developing microcephaly in affected fetuses.

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“…Even though the ZIKV infection in the second and third trimester of pregnancy seemed to be a lower risk compared to ZIKV infection in the first trimester, it is important to highlight that this infection carries a risk for the development of microcephaly and other adverse pregnancy outcomes throughout the full duration of pregnancy [4,46,47]. There is still a lack of knowledge on the magnitude of the risk of newborns infected by ZIKV developing microcephaly later in childhood [48,49].…”

Section: Discussionmentioning

confidence: 99%

Another piece on the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis.

Gallo

Martínez-Cajas

Peixoto

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Although it is known that Zika virus (ZIKV) infection during pregnancy may lead to microcephaly in the foetus, the risk factors associated to this tragic disorder remain unclear. We conducted a systematic review and meta-analysis toto assess risk factors associated with the incidence of microcephaly in congenital ZIKV infection. Methods: We conducted a comprehensive search in Ovid MEDLINE, Ovid MEDLINE (R) Epub ahead of print, Embase, Embase Classic, Web of Science, CINAHL, Cochrane CENTRAL, LILACS and various thesis databases to identify human studies reporting microcephaly associated with congenital ZIKV infection. We requested primary data from authors of the studies included in this review to calculate summary estimates and conduct meta-analysis of the most prevalent factors. Results: We screened 4,106 titles and abstracts, and identified 12 studies for inclusion in the systematic review. The assessment of ZIKV infection and the definition of microcephaly varied among studies. A total of 6,154 children/foetuses were enrolled; of those, 1,120 (18.20%) had a diagnostic of ZIKV infection, of which 509 (45.45%) were diagnosed with microcephaly. Nine studies addressed the link between congenital ZIKV infection and neurological findings in foetuses/ children. Half of the studies provided primary data. Two out of eleven factors of interest were associated with microcephaly: infant’s sex – males presented a higher risk of microcephaly compared to females (RR 1.30, 95% CI 1.14, 1.49); and the stage of pregnancy when infection occurred - infection in the first trimester of pregnancy had a higher risk of microcephaly (RR 1.41, 95% CI 1.09 to 1.82), compared to infection at other stages of pregnancy. Conclusion: Our findings support the female-biased resistance hypothesis and reinforce the risk associated with the stage of pregnancy when Zika virus infection occurs. Continued surveillance of ZIKV during pregnancy is needed to identify additional factors that could contribute to developing microcephaly in affected foetuses.

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Zika virus infection in children: epidemiology and clinical manifestations

Abstract: While much has been learned about congenital Zika syndrome, the full spectrum of this infection is not yet known. This review is based on current, limited data about Zika vírus infection. As more information becomes available, we will have a more accurate picture of this new disease.

Cited by 26 publications

References 62 publications

Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis

Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis

Another piece of the Zika puzzle: Assessing the associated factors to microcephaly in a systematic review and meta-analysis.

Another piece on the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis.

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