2017
DOI: 10.3201/eid2308.170479
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Zika Virus Infection in Patient with No Known Risk Factors, Utah, USA, 2016

Abstract: In 2016, Zika virus disease developed in a man (patient A) who had no known risk factors beyond caring for a relative who died of this disease (index patient). We investigated the source of infection for patient A by surveying other family contacts, healthcare personnel, and community members, and testing samples for Zika virus. We identified 19 family contacts who had similar exposures to the index patient; 86 healthcare personnel had contact with the index patient, including 57 (66%) who had contact with bod… Show more

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Cited by 13 publications
(9 citation statements)
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“…Of interest, we detected prolonged oral shedding and the presence of infectious virus in subcutaneously and intravaginally inoculated AGMs. While experimental evidence indicates there is less potential for transmission via infectious saliva [63], super-shedders could potentiate this mode of transmission [90,91]. Our results are similar to the majority of human case reports, which describe a generally asymptomatic infection despite low-level viremias and the detection of vRNA shedding in bodily fluids.…”
Section: Discussionsupporting
confidence: 86%
“…Of interest, we detected prolonged oral shedding and the presence of infectious virus in subcutaneously and intravaginally inoculated AGMs. While experimental evidence indicates there is less potential for transmission via infectious saliva [63], super-shedders could potentiate this mode of transmission [90,91]. Our results are similar to the majority of human case reports, which describe a generally asymptomatic infection despite low-level viremias and the detection of vRNA shedding in bodily fluids.…”
Section: Discussionsupporting
confidence: 86%
“…Mathematical models suggest that a ZIKV-positive individual can lead to approximately 2–5 additional infections via mosquito transmission [ 13 , 14 ]. ZIKV transmission is predominantly mosquito-borne, but sexual transmission has been reported as well [ 13 , 15 , 16 ]. Salivary transmission has been deemed possible but unlikely [ 13 , 15 17 ].…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, an increased incidence of Guillain-Barré syndrome has been consistently noted after Zika outbreaks in multiple countries [5,6,7]. Other complications and severe outcomes have been very rarely reported, ranging from low platelets to death, usually in patients with additional comorbid factors that may have contributed to the pathogenicity of their illness [76,77,78,79].…”
Section: Natural History Of Zikv Infection Host Immune Response mentioning
confidence: 99%