ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk

Hallet, Edouard; Flamand, Claude; Rousset, Dominique; Bonifay, Timothée; Fritzell, Camille; Matheus, Séverine; Dueymes, Maryvonne; Ntab, Balthazar

doi:10.1371/journal.pntd.0008193

Cited by 14 publications

(11 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The present results suggest that early in the epidemic, the populations most at risk for CHIKV infection were the most socially vulnerable populations in the poorest neighborhoods, whereas DENV appeared to have affected a richer population and richer areas [ 66 •]. Similar findings were found during Zika’s outbreak in French Guiana [ 67 ]. Further investigations are required to disentangle the potential determinants of this observation.…”

Section: Specific Populationssupporting

confidence: 74%

Contribution of Research in the West Indies and Northeast Amazonia to Knowledge of the 2014–2015 Chikungunya Epidemic in the Americas

et al. 2021

Self Cite

View full text Add to dashboard Cite

Purpose of Review Although the chikungunya virus was discovered more than 60 years ago, it has only really been studied since the outbreak in La Reunion in 2005–2006. Ten years later, between 2014 and 2015, the chikungunya virus spread throughout the Americas, affecting millions of people. The objective of this review is to describe the contributions of research on chikungunya virus infection gained from epidemic in the West Indies and the Guiana Shield. Recent Findings Prevalence data were similar to those found in the Indian Ocean or Asia during epidemics. Clinically, there is now a better understanding of the typical, atypical, and severe forms. Several studies have insisted on the presence of neurological forms of chikungunya infection, such as encephalitis or Guillain–Barré syndrome. Cases of septic shock due to chikungunya virus as well as thrombotic thrombocytopenic purpura were described for the first time. Given the magnitude of the epidemic and the large number of people affected, this has led to a better description and new classifications of chikungunya virus infections in specific populations such as pregnant women, the elderly, and children. Several studies also described the behavior of populations faced with an emerging disease. Summary Current epidemiological data from tropical regions highlights the risk of spreading emerging diseases at higher latitudes, especially concerning arboviruses, since the vector Aedes albopictus is already established in many parts of northern countries. A better understanding of the disease and its epidemic dynamics will foster better management, the crucial importance of which was demonstrated during the COVID-19 epidemic.

show abstract

Section: Specific Populationssupporting

confidence: 74%

Contribution of Research in the West Indies and Northeast Amazonia to Knowledge of the 2014–2015 Chikungunya Epidemic in the Americas

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Seroprevalence levels were often higher than those observed in the coastal zone. This situation probably reflects a socio-economic and environmental context favorable to the transmission of arboviruses due to explosive demographic growth accentuated by large movements of people living in precarious conditions [ 41 ] and high anthropization conducive to the proliferation of Ae. aegypti populations in this part of the territory.…”

Section: Discussionmentioning

confidence: 99%

Spatial Distribution and Burden of Emerging Arboviruses in French Guiana

Bailly¹,

Rousset

Fritzell³

et al. 2021

Viruses

Self Cite

View full text Add to dashboard Cite

Despite the health, social and economic impact of arboviruses in French Guiana, very little is known about the extent to which infection burden is shared between individuals. We conducted a large multiplexed serological survey among 2697 individuals from June to October 2017. All serum samples were tested for IgG antibodies against DENV, CHIKV, ZIKV and MAYV using a recombinant antigen-based microsphere immunoassay with a subset further evaluated through anti-ZIKV microneutralization tests. The overall DENV seroprevalence was estimated at 73.1% (70.6–75.4) in the whole territory with estimations by serotype at 68.9% for DENV-1, 38.8% for DENV-2, 42.3% for DENV-3, and 56.1% for DENV-4. The overall seroprevalence of CHIKV, ZIKV and MAYV antibodies was 20.3% (17.7–23.1), 23.3% (20.9–25.9) and 3.3% (2.7–4.1), respectively. We provide a consistent overview of the burden of emerging arboviruses in French Guiana, with useful findings for risk mapping, future prevention and control programs. The majority of the population remains susceptible to CHIKV and ZIKV, which could potentially facilitate the risk of further re-emergences. Our results underscore the need to strengthen MAYV surveillance in order to rapidly detect any substantial changes in MAYV circulation patterns.

show abstract

“…Noticeably, AHR is highly expressed in the human placenta and its expression is upregulated in placentas of women suffering unexplained miscarriages ( 105 , 106 ). Hence, it is conceivable that sustained AHR activation in women exposed to pollutants and living in impoverished conditions with degraded housing and malnutrition ( 107 , 108 ) might increase their susceptibility to ZIKV infection and ZIKV congenital syndrome.…”

Section: Ahr and Viral Infectionsmentioning

confidence: 99%

The Aryl Hydrocarbon Receptor as a Modulator of Anti-viral Immunity

2021

View full text Add to dashboard Cite

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor, which interacts with a wide range of organic molecules of endogenous and exogenous origin, including environmental pollutants, tryptophan metabolites, and microbial metabolites. The activation of AHR by these agonists drives its translocation into the nucleus where it controls the expression of a large number of target genes that include the AHR repressor (AHRR), detoxifying monooxygenases (CYP1A1 and CYP1B1), and cytokines. Recent advances reveal that AHR signaling modulates aspects of the intrinsic, innate and adaptive immune response to diverse microorganisms. This review will focus on the increasing evidence supporting a role for AHR as a modulator of the host response to viral infection.

show abstract

ZIKA Virus infection in pregnant women in French Guiana: More precarious-more at risk

Cited by 14 publications

References 13 publications

Contribution of Research in the West Indies and Northeast Amazonia to Knowledge of the 2014–2015 Chikungunya Epidemic in the Americas

Contribution of Research in the West Indies and Northeast Amazonia to Knowledge of the 2014–2015 Chikungunya Epidemic in the Americas

Spatial Distribution and Burden of Emerging Arboviruses in French Guiana

The Aryl Hydrocarbon Receptor as a Modulator of Anti-viral Immunity

Contact Info

Product

Resources

About