2019
DOI: 10.1128/jvi.00638-19
|View full text |Cite
|
Sign up to set email alerts
|

Zika Virus Infection Induces DNA Damage Response in Human Neural Progenitors That Enhances Viral Replication

Abstract: Zika virus (ZIKV) infection attenuates the growth of human neural progenitor cells (hNPCs). As these hNPCs generate the cortical neurons during early brain development, the ZIKV-mediated growth retardation potentially contributes to the neurodevelopmental defects of the congenital Zika syndrome. Here, we investigate the mechanism by which ZIKV manipulates the cell cycle in hNPCs and the functional consequence of cell cycle perturbation on the replication of ZIKV and related flaviviruses. We demonstrate that ZI… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

5
52
0

Year Published

2019
2019
2024
2024

Publication Types

Select...
8
1
1

Relationship

0
10

Authors

Journals

citations
Cited by 56 publications
(60 citation statements)
references
References 53 publications
5
52
0
Order By: Relevance
“…Following in vitro ZIKV infection, cortical neuronal progenitors show unregulated cell replication cycles, decreased cell division rate, and increased apoptosis (157). ZIKV is capable of breaking double-stranded DNA and inhibiting DNA repair pathways during the cell replication cycle (158). In addition, permanence in phase S increases viral replication in neuronal progenitors, favoring increased neuronal damage in CZS.…”
Section: Mechanisms Involved In Congenital Infectionmentioning
confidence: 99%
“…Following in vitro ZIKV infection, cortical neuronal progenitors show unregulated cell replication cycles, decreased cell division rate, and increased apoptosis (157). ZIKV is capable of breaking double-stranded DNA and inhibiting DNA repair pathways during the cell replication cycle (158). In addition, permanence in phase S increases viral replication in neuronal progenitors, favoring increased neuronal damage in CZS.…”
Section: Mechanisms Involved In Congenital Infectionmentioning
confidence: 99%
“…In vitro studies have reported that ZikV infects human embryonic cortical neural progenitor cells (hNPCs), inducing cell cycle dysregulation and increased cell death (Tang et al, 2016). In addition, by studying the mechanisms by which ZikV modulates the cell cycle of hNPCs, it has been observed that the virus induces DNA breaks which, in turn, inhibits cell cycle progression from the S phase, thus preventing host DNA replication completion (Hammack et al, 2019). Using an in vivo congenital ZikV infection model, it has been verified that, besides neurogenesis impacts, the infection also affects angiogenesis.…”
Section: Congenital Zika Virus Infectionmentioning
confidence: 99%
“…For instance, HSV-1 and human parvovirus B19 (B19V) induce ATR activation for their DNA replication [ 141 , 142 ]. In contrast, the Zika virus (ZIKV) inhibits activation of the ATR/Chk1 pathway to benefit its viral replication [ 143 ]. Adenovirus can reduce ATR phosphorylation or promote TopBP1 degradation to contribute to viral production efficiency [ 144 , 145 ].…”
Section: The Role Of Atr Ddr In the Molecular Pathogenesis Of Hpvmentioning
confidence: 99%