Zika Virus Outbreak, assisted reproduction patients and pregnancy

Joob, Beuy; Wiwanitkit,

doi:10.5935/1518-0557.20180007

Cited by 4 publications

(4 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immunological cross-reactivity between the flaviviruses, especially between DENV and ZIKV, is an issue concerning serological diagnosis [3,4]. Besides misdiagnosis as other flavivirus infections, possible explanations may include virus factors (e.g., low pathogenicity of indigenous ZIKV strain, low ZIKV viremia), host factors (e.g., ZIKV protection from previous natural or acquired immunity from other flavivirus infections or vaccinations), and environmental factors (e.g., mosquito transmissibility, no natural reservoir of ZIKV) [60][61][62][63][64][65]. More research is needed to better understand questions related to these factors.…”

Section: Laboratory Testing Considerationsmentioning

confidence: 99%

“…More research is needed to better understand questions related to these factors. ZIKV infection in Southeast Asia has been generally characterized by asymptomatic or mild disease, with symptoms mainly consisting of fever, muscle pain, joint pain and sometimes rash or headache; more serious symptoms have been reported less commonly [60][61][62][63][64][65]. Individuals may not seek care for mild symptoms and patients with symptoms.…”

Section: Laboratory Testing Considerationsmentioning

confidence: 99%

See 1 more Smart Citation

Characteristics, risk factors, and outcomes related to Zika virus infection during pregnancy in Northeastern Thailand: A prospective pregnancy cohort study, 2018–2020

Wongsawat,

Thamthitiwat,

Hicks

et al. 2024

PLoS Negl Trop Dis

View full text Add to dashboard Cite

Background In response to the 2015–2016 Zika virus (ZIKV) outbreak and the causal relationship established between maternal ZIKV infection and adverse infant outcomes, we conducted a cohort study to estimate the incidence of ZIKV infection in pregnancy and assess its impacts in women and infants. Methodology/Principal findings From May 2018-January 2020, we prospectively followed pregnant women recruited from 134 participating hospitals in two non-adjacent provinces in northeastern Thailand. We collected demographic, clinical, and epidemiologic data and blood and urine at routine antenatal care visits until delivery. ZIKV infections were confirmed by real-time reverse transcriptase polymerase chain reaction (rRT-PCR). Specimens with confirmed ZIKV underwent whole genome sequencing. Among 3,312 women enrolled, 12 (0.36%) had ZIKV infections, of which two (17%) were detected at enrollment. Ten (83%, 3 in 2nd and 7 in 3rd trimester) ZIKV infections were detected during study follow-up, resulting in an infection rate of 0.15 per 1,000 person-weeks (95% CI: 0.07–0.28). The majority (11/12, 91.7%) of infections occurred in one province. Persistent ZIKV viremia (42 days) was found in only one woman. Six women with confirmed ZIKV infections were asymptomatic until delivery. Sequencing of 8 ZIKV isolates revealed all were of Asian lineage. All 12 ZIKV infected women gave birth to live, full-term infants; the only observed adverse birth outcome was low birth weight in one (8%) infant. Pregnancies in 3,300 ZIKV-rRT-PCR-negative women were complicated by 101 (3%) fetal deaths, of which 67 (66%) had miscarriages and 34 (34%) had stillbirths. There were no differences between adverse fetal or birth outcomes of live infants born to ZIKV-rRT-PCR-positive mothers compared to live infants born to ZIKV-rRT-PCR-negative mothers. Conclusions/Significance Confirmed ZIKV infections occurred infrequently in this large pregnancy cohort and observed adverse maternal and birth outcomes did not differ between mothers with and without confirmed infections.

show abstract

Section: Laboratory Testing Considerationsmentioning

confidence: 99%

Section: Laboratory Testing Considerationsmentioning

confidence: 99%

Characteristics, risk factors, and outcomes related to Zika virus infection during pregnancy in Northeastern Thailand: A prospective pregnancy cohort study, 2018–2020

Wongsawat,

Thamthitiwat,

Hicks

et al. 2024

PLoS Negl Trop Dis

View full text Add to dashboard Cite

show abstract

“…In 1992, Eagles proposed a potential link between poliovirus infection and schizophrenia, but this hypothesis was not explored further [ 136 , 137 ]. There has also been a hypothesis that Zika virus infection may contribute to the development of schizophrenia, but there is no clinical evidence supporting this theory [ 138 , 139 ]. However, as a neurotropic virus, Zika’s impact on brain development has been widely researched, and it is now known that Zika infection in pregnant women can lead to microcephaly in their offspring [ 140 ].…”

Section: Risk Factorsmentioning

confidence: 99%

Viral Infections and Schizophrenia: A Comprehensive Review

Kotsiri

Resta

Spyrantis

et al. 2023

Viruses

View full text Add to dashboard Cite

Schizophrenia is a complex mental disorder with multiple genetic and environmental factors contributing to its pathogenesis. Viral infections have been suggested to be one of the environmental factors associated with the development of this disorder. We comprehensively review all relevant published literature focusing on the relationship between schizophrenia and various viral infections, such as influenza virus, herpes virus 1 and 2 (HSV-1 and HSV-2), cytomegalovirus (CMV), Epstein-Barr virus (EBV), retrovirus, coronavirus, and Borna virus. These viruses may interfere with the normal maturation of the brain directly or through immune-induced mediators, such as cytokines, leading to the onset of schizophrenia. Changes in the expression of critical genes and elevated levels of inflammatory cytokines have been linked to virally-induced infections and relevant immune activities in schizophrenia. Future research is necessary to understand this relationship better and provide insight into the molecular mechanisms underlying the pathophysiology of schizophrenia.

show abstract

“…Eagles in an early paper in 1992 suggested a possible connection between poliovirus infection and schizophrenia, but his hypothesis was never tested [105,106]. A possible role of Zika virus infection has been proposed in the pathogenesis of schizophrenia but there are no data supporting this hypothesis [107,108].…”

Section: Other Viral Infectionsmentioning

confidence: 99%

Association between Prenatal Viral Infections and the Occurrence of Schizophrenia in Adulthood

Kotsiri

Spyrantis

Panotopoulos³

et al. 2022

JAMMR

View full text Add to dashboard Cite

Schizophrenia is a severe mental disorder that affects approximately 1% of the population worldwide. Genetics and environmental factors appear to contribute to the pathogenesis of schizophrenia. Epidemiological studies have focused on the relationship between viral infection during pregnancy and an increased risk of developing schizophrenia in offspring. The aim of our review is to summarize whether viral infections during pregnancy can lead to psychiatric disorders and especially to schizophrenia in adulthood. For that purpose we undertaken a thorough search in Pubmed using as keywords viral infections, schizophrenia, perinatal infections and virus. Epidemiological studies have focused on the relationship between perinatal viral infections and an increased risk of developing schizophrenia in offspring. Influenza virus, various members of the Herpesviridae family, retroviruses, borna virus are discussed as examples of viral infections associated with schizophrenia. These viral infections appear to interfere with the normal maturation of the brain and may lead to the subsequent onset of schizophrenia. Another epidemiological aspect of schizophrenia is the fact that it presents a seasonal prevalence with peaks in offsprings which wer born during winter and spring. It is also possible for an infection occurring in infancy to reactivate later, as is known to happen with herpes viruses. Overall,various studies showed that prenatal maternal infections appear to increase the risk of developing schizophrenia in the offspring, and this is due to the body's immune response to the infection, and not in exposure to specific viral or bacterial pathogens.

show abstract

Zika Virus Outbreak, assisted reproduction patients and pregnancy

Cited by 4 publications

References 2 publications

Characteristics, risk factors, and outcomes related to Zika virus infection during pregnancy in Northeastern Thailand: A prospective pregnancy cohort study, 2018–2020

Characteristics, risk factors, and outcomes related to Zika virus infection during pregnancy in Northeastern Thailand: A prospective pregnancy cohort study, 2018–2020

Viral Infections and Schizophrenia: A Comprehensive Review

Association between Prenatal Viral Infections and the Occurrence of Schizophrenia in Adulthood

Contact Info

Product

Resources

About