Zinc and copper in the serum of diabetic patients

Car, Nikica; Car, Antuanet; Granić, M; Skrabalo, Z; Momčilović, Berislav

doi:10.1007/bf02784618

Cited by 36 publications

(14 citation statements)

References 10 publications

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“…Serum magnesium concentration has been reported to decrease in diabetics [8,9]; furthermore, increased renal loss of chromium and selenium [10,11] and also hyperzincuria have been observed [12,13]. Similar results have been published by Hungarian authors [11,14].…”

Section: Introductionsupporting

confidence: 78%

Serum Selenium Concentrations Correlate Significantly with Inflammatory Biomarker High-sensitive CRP Levels in Hungarian Gestational Diabetic and Healthy Pregnant Women at Mid-pregnancy

Molnár

Garamvölgyi

Herold

et al. 2007

Biol Trace Elem Res

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Selenium is an essential trace element and a component of various enzymes with antioxidant functions. High-sensitive C-reactive protein (hsCRP) is an early indicator of increased lipid peroxidation. The serum selenium concentration, lipid parameters, and hsCRP values of gestational diabetic pregnant women (GD), control pregnant women (CP), and healthy nonpregnant controls (HC) were compared. Blood was taken between the 24th and the 28th week of pregnancy when the oral glucose tolerance test was performed. Selenium concentration was determined by atomic absorption spectrometry after hydride generation. HsCRP was measured by immunturbidimetry. HC had significantly higher serum selenium concentrations than GD and CP women (HC = 77.4 +/- 14.82, GD = 51.7 +/- 11.62, and CP = 40.5 +/- 8.03 microg/l, respectively). HsCRP values of both GD and nondiabetic pregnant women were significantly higher compared to controls. Significant negative correlations were found between serum selenium and total cholesterol, low-density lipoprotein cholesterol, and hsCRP values indicating that low selenium levels are associated with increased lipid peroxidation. Serum selenium concentrations of Hungarian pregnant women are low compared to internationally published data.

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Section: Introductionsupporting

confidence: 78%

Serum Selenium Concentrations Correlate Significantly with Inflammatory Biomarker High-sensitive CRP Levels in Hungarian Gestational Diabetic and Healthy Pregnant Women at Mid-pregnancy

Molnár

Garamvölgyi

Herold

et al. 2007

Biol Trace Elem Res

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“…The Zn/Cu ratio was chosen as an index of distribution of trace elements, because this ratio was previously shown to correlate with carcinogenicity and altered immune function [48][49][50][51]. Notably, changes in Zn/Cu ratio in the present study were still tissue-specific; high-dose pDCB led to a marked Zn/Cu ratio increase in the liver and a trend towards a decrease in blood, whereas the Zn/Cu ratio changes in the kidney were statistically insignificant.…”

Section: Discussioncontrasting

confidence: 58%

“…To characterize the effects of pDCB on Zn and Cu homeostasis, the ratio of tissue Zn to Cu was calculated [48][49][50][51], as shown in Fig. 8.…”

Section: Effects Of Pdcb On the Ratio Zn To Cu In The Liver And Kidneymentioning

confidence: 99%

Lipid Peroxidation and Changes of Trace Elements in Mice Treated with Paradichlorobenzene

Wang

Yin

et al. 2009

Biol Trace Elem Res

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Paradichlorobenzene (pDCB) has been used as a space deodorant and moth repellant, as well as an intermediate in the chemical industry. Given its broad applications and high volatility, considerable concern exists regarding the adverse health effects of pDCB in the home and the workplace. In this study, changes in lipid peroxidation, antioxidants, and trace element levels in the liver and kidney of pDCB-treated mice were investigated to determine their roles in toxicity. Mice were orally gavaged once daily for seven consecutive days with pDCB (0 (corn oil control), 450, and 900 mg/kg). The level of malondialdehyde (MDA), an end product of lipid peroxidation, markedly increased in the high-dose pDCB group in both the liver and kidney compared with the control group. Changes in hepatic levels of reduced glutathione (GSH) in the pDCB groups were indistinguishable from the control group, while renal levels of reduced GSH in the high-dose pDCB group were significantly lowered in comparison to the control and the low-dose groups. Superoxide dismutase (SOD) activity in the liver of mice treated with pDCB showed a downward trend, whereas there was no consistent trend associated with changes in SOD activity in the kidney. Additionally, renal iron levels in the high-dose pDCB group were significantly decreased compared with the low-dose group and the controls, whereas hepatic iron content in the low-dose pDCB group was significantly lower compared with the controls. Selenium and zinc levels in the kidney were both significantly decreased in the high-dose pDCB group vs. the control and low-dose groups. There were no treatment-induced changes in copper levels in either the kidney or liver. However, a significant increase was found in the liver zinc/copper ratio in the high-dose pDCB group vs. the controls. In addition, blood zinc levels showed a downward trend with increased pDCB dosage. These results suggest that pDCB toxicity is mediated by oxidative damage and tissue-specific alterations in trace element levels both in the liver and the kidney of mice.

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“…Except for higher levels of serum Cu observed in subjects with DN, we did not find any significant difference for either serum or urinary Cu among uncomplicated T2D patients or T2D patients with either DR or DPN. An earlier study reported no significant differences for either Zn or Cu levels, as well as the Zn/Cu ratio in diabetic patients with and without complications [34]. Another cross-sectional study that evaluated 24 h urinary Cu levels in T2D patients ( n = 42) with DN in comparison with patients without DN ( n = 40) reported that diabetic patients with DN have increased urinary Cu excretion [31].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Serum and Urinal Copper and Zinc in Chinese Northeast Population with the Prediabetes or Diabetes with and without Complications

Zhou

Liu

et al. 2013

Oxidative Medicine and Cellular Longevity

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This study investigated the association of copper and zinc levels in the serum or urine of patients living in northeast China, with either prediabetes or diabetes. From January 2010 to October 2011, patients with type 1 diabetes (T1D, n = 25), type 2 diabetes (T2D, n = 137), impaired fasting glucose (IFG, n = 12) or impaired glucose tolerance (IGT, n = 15), and age/gender matched controls (n = 50) were enrolled. In the T2D group, there were 24 patients with nephropathy, 34 with retinopathy, and 50 with peripheral neuropathy. Serum copper levels were significantly higher in IFG, IGT, and T2D groups. Serum zinc level was dramatically lower, and urinary zinc level was significantly higher in both T1D and T2D subjects compared with controls. The serum zinc/copper ratio was significantly lower in all the patients with IFG, ITG, T1D, and T2D. The serum copper level was positively associated with HbA1c in T2D subjects. Simvastatin treatment in T2D patients had no significant effect on serum and urinary copper and zinc. These results suggest the need for further studies of the potential impact of the imbalanced serum copper and zinc levels on metabolic syndrome, diabetes, and diabetic complications.

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Zinc and copper in the serum of diabetic patients

Cited by 36 publications

References 10 publications

Serum Selenium Concentrations Correlate Significantly with Inflammatory Biomarker High-sensitive CRP Levels in Hungarian Gestational Diabetic and Healthy Pregnant Women at Mid-pregnancy

Serum Selenium Concentrations Correlate Significantly with Inflammatory Biomarker High-sensitive CRP Levels in Hungarian Gestational Diabetic and Healthy Pregnant Women at Mid-pregnancy

Lipid Peroxidation and Changes of Trace Elements in Mice Treated with Paradichlorobenzene

Analysis of Serum and Urinal Copper and Zinc in Chinese Northeast Population with the Prediabetes or Diabetes with and without Complications

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