Zinc as a countermeasure for cadmium toxicity

Yu, Haoyong; Zhen, Juan; Leng, Jinhua; Cai, Lu; Ji, Honglei; Keller, Bradley B.

doi:10.1038/s41401-020-0396-4

Cited by 61 publications

(49 citation statements)

References 112 publications

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“…Available data, including the findings of our studies, indicate many beneficial effects of Zn administration also in the alleviation of toxicity of heavy metals, including cadmium (Cd) [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Chronic exposure to Cd of the general population is a global health concern and, despite numerous efforts to restrict its release into the environment, prognoses suggest that human’s intoxication with this toxic element will elevate because it does not undergo biodegradation [ 23 ].…”

Section: Introductionmentioning

confidence: 85%

“…Numerous investigations have shown that Zn can decrease Cd content in the body [ 10 , 11 , 12 , 17 ] and alleviate its injurious action in various organs and systems, mainly the kidney, liver, and bone tissue [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 20 , 21 ]. The mechanism of Zn-mediated protection towards the harmful action of Cd has not been completely explored yet.…”

Section: Introductionmentioning

confidence: 99%

“…However, the involvement in these pathways of direct competition between these two metals for the systems of transport and sites of binding in cells, Zn-induced synthesis of metallothionein (MT), and strong antioxidative potential of this bioelement is well established [ 11 , 12 , 14 , 15 , 16 , 17 , 18 , 20 , 21 , 22 , 37 ]. Zn, as a component of the active center of an antioxidative enzyme—superoxide dismutase (SOD)—and a factor decreasing the activity of oxidases, plays a very important role in the maintenance of the balance between pro- and antioxidants in cells [ 2 , 3 , 17 ]. Moreover, this element may also up-regulate the activation of antioxidant transcription factors and the expression of genes for antioxidants [ 2 , 3 , 17 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…Zn, as a component of the active center of an antioxidative enzyme—superoxide dismutase (SOD)—and a factor decreasing the activity of oxidases, plays a very important role in the maintenance of the balance between pro- and antioxidants in cells [ 2 , 3 , 17 ]. Moreover, this element may also up-regulate the activation of antioxidant transcription factors and the expression of genes for antioxidants [ 2 , 3 , 17 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…In our previous investigations carried out in the rat model of moderate and relatively high chronic human intoxication with Cd (5 and 50 mg/L, respectively, for 6 and 12 months) we have noted that the enhancement of the intake of Zn (30 and 60 mg/L) lowered Cd accumulation in the body ( Table S1 ) and prevented this xenobiotic-induced damage to the bone tissue and liver, including the action resulting from its pro-oxidative properties [ 10 , 11 , 12 , 13 , 14 , 15 ]. Taking into account strong antioxidative ability of Zn [ 2 , 3 ], as well as the results of our previous studies [ 10 , 11 , 12 , 13 , 14 , 15 , 16 ] and available literature data [ 17 , 18 , 19 , 20 , 21 , 22 ] showing the protective effects of this bioelement against Cd toxicity, we have hypothesized that the increased consumption of Zn under the repeated exposure to Cd may also prevent oxidative stress and its consequences in the nervous tissue. Results of some authors suggest that Zn may alleviate the pro-oxidative action of Cd in the brain [ 18 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Enhanced Zinc Intake Protects against Oxidative Stress and Its Consequences in the Brain: A Study in an In Vivo Rat Model of Cadmium Exposure

et al. 2021

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We examined, in a rat model of moderate environmental human exposure to cadmium (Cd), whether the enhanced intake of zinc (Zn) may protect against Cd-caused destroying the oxidative/antioxidative balance and its consequences in the brain. The intoxication with Cd (5 mg/L, 6 months) weakened the enzymatic (superoxide dismutase, glutathione peroxidase, catalase) and non-enzymatic (total thiol groups, reduced glutathione) antioxidative barrier decreasing the total antioxidative status and increased the concentrations of pro-oxidants (hydrogen peroxide, myeloperoxidase) in this organ and its total oxidative status. These resulted in the development of oxidative stress and oxidative modifications of lipids and proteins. The co-administration of Zn (30 and 60 mg/L enhancing this element intake by 79% and 151%, respectively) importantly protected against Cd accumulation in the brain tissue and this xenobiotic-induced development of oxidative stress and oxidative damage to lipids and proteins. Moreover, this bioelement also prevented Cd-mediated oxidative stress evaluated in the serum. The favorable effect of Zn was caused by its independent action and interaction with Cd. Concluding, the enhancement of Zn intake under oral exposure to Cd may prevent the oxidative/antioxidative imbalance and oxidative stress in the brain and thus protect against injury of cellular macromolecules in the nervous system.

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Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Enhanced Zinc Intake Protects against Oxidative Stress and Its Consequences in the Brain: A Study in an In Vivo Rat Model of Cadmium Exposure

et al. 2021

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The Scope of the Applicability of Non‐relativistic DFT Calculations of NMR Chemical Shifts in Pyridine‐Metal Complexes for Applied Applications

Shenderovich

2024

ChemPhysChem

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Heavy metals are toxic, but it is impossible to stop using them. Considering the variety of molecular systems in which they can be present, the multicomponent nature and disorder of the structure of such systems, one of the most effective methods for studying them is NMR spectroscopy. This determines the need to calculate NMR chemical shifts for expected model systems. For elements beyond the third row of the periodic table, corrections for relativistic effects are necessary when calculating NMR parameters. Such corrections may be necessary even for light atoms due to the shielding effect of a neighboring heavy atom. This work examines the extent to which non‐relativistic DFT calculations are able to reproduce experimental 15N and 113Cd NMR chemical shift tensors in pyridine‐metal coordination complexes. It is shown that while for the calculation of 15N NMR chemical shift tensors there is no real need to consider relativistic corrections, for 113Cd, on the contrary, none of the tested calculation methods could reproduce the experimentally obtained tensor to any extent correctly.

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Selenium and zinc alleviate hepatotoxicity induced by heavy metal mixture (cadmium, mercury, lead and arsenic) via attenuation of inflammo‐oxidant pathways

Ozoani,

Ezejiofor,

Okolo

et al. 2023

Environmental Toxicology

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Heavy metals (HM) are believed to be injurious to humans. Man is exposed to them on daily basis unknowingly, with no acceptable protocol to manage its deleterious effects. These metals occur as mixture of chemicals with varying concentrations in our atmosphere. There are growing calls for the use of essential metals in mitigating the injurious effects induced by heavy metals exposure to man; therefore, the aim of this study was to evaluate the protective effects of essential metals (Zinc and Selenium) in a mixture of heavy metal toxicity. In this study, except for negative controls, all other groups were treated with lead (PbCl2, 20 mg kg−1); cadmium (CdCl2, 1.61 mg kg−1); mercury (HgCl2, 0.40 mg kg−1), and arsenic (NaAsO3, 10 mg kg−1) that were formed in distilled water. Pb, Cd, As, and Hg were administered as mixtures to 35, 6 weeks old rats weighing between 80 to 100 g for 60 days. Group I served as normal control without treatment, group II positive control received HM mixture, while groups III to V received HMM with Zn, Se, and Zn + Se respectively. Animal and liver weights, HM accumulation in the liver, food intake (FI), water intake (WI), liver function test, malondialdehyde (MDA), and inflammatory/transcription factor/apoptosis markers were checked. Also, antioxidant enzymes, and histological studies were carried out. Metal mixture accumulated in the liver and caused toxicities which were ameliorated by Zn and Se administration. HM caused significant decrease in FI, WI and distorted the level of liver enzymes, lipid peroxidation, inflammatory markers, antioxidants and architecture of the liver. Co administration with Zn or Se or both reversed the distortions. This study lays credence to the evolving research on the public health implications of low dose metal mixtures and the possible ameliorative properties of Zn and Se.

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Zinc as a countermeasure for cadmium toxicity

Cited by 61 publications

References 112 publications

Enhanced Zinc Intake Protects against Oxidative Stress and Its Consequences in the Brain: A Study in an In Vivo Rat Model of Cadmium Exposure

Enhanced Zinc Intake Protects against Oxidative Stress and Its Consequences in the Brain: A Study in an In Vivo Rat Model of Cadmium Exposure

The Scope of the Applicability of Non‐relativistic DFT Calculations of NMR Chemical Shifts in Pyridine‐Metal Complexes for Applied Applications

Selenium and zinc alleviate hepatotoxicity induced by heavy metal mixture (cadmium, mercury, lead and arsenic) via attenuation of inflammo‐oxidant pathways

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