Zinc complexes of salicylaldehydes: Synthesis, characterization and DNA-binding properties

Zianna, Ariadni; Psomas, George; Hatzidimitriou, A.; Coutouli‐Argyropoulou, Evdoxia; Lalia‐Kantouri, Maria

doi:10.1016/j.jinorgbio.2013.07.031

Cited by 51 publications

(43 citation statements)

References 44 publications

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“…According to the Scatchard equation, [41] a plot of r / C f versus r gave K b values of (0.12±0.05)×10 5 and (3.11±0.09)×10 5 M −1 from the fluorescence data for the CQPQ‐gold(I) hybrid and CQDP respectively, showing a possible displacement of EB similar to other metal complexes with reported biological activity [42–44] . This displacement can indicate intercalation or minor groove interaction [45–48] .…”

Section: Resultsmentioning

confidence: 72%

A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent

et al. 2020

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Plasmodium parasites kill 435 000 people around the world every year due to unavailable vaccines, a limited arsenal of antimalarial drugs, delayed treatment, and the reduced clinical effectiveness of current practices caused by drug resistance. Therefore, there is an urgent need to discover and develop new antiplasmodial candidates. In this work, we present a novel strategy to develop a multitarget metallic hybrid antimalarial agent with possible dual efficacy in both sexual and asexual erythrocytic stages. A hybrid of antimalarial drugs (chloroquine and primaquine) linked by gold(I) was synthesized and characterized by spectroscopic and analytical techniques. The CQPQ‐gold(I) hybrid molecule affects essential parasite targets, it inhibits β‐hematin formation and interacts moderately with the DNA minor groove. Its interaction with PfTrxR was also examined in computational modeling studies. The CQPQ‐gold(I) hybrid displayed an excellent in vitro antimalarial activity against the blood‐stage of Plasmodium falciparum and liver‐stage of Plasmodium berghei and efficacy in vivo against P. berghei, thereby demonstrating its multiple‐stage antiplasmodial activity. This metallic hybrid is a promising chemotherapeutic agent that could act in the treatment, prevention, and transmission of malaria.

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Section: Resultsmentioning

confidence: 72%

A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent

et al. 2020

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“…Benzoic acid and shikimic acid naturally exist in many plants and serve as the important precursors for the biosynthesis of many other organic substances [41,42]. Further, benzoic acid is usually known to relieve skin ailments such as acne, ringworm, and tinea pedis [43], whereas shikimic acid is often associated with pharmacological effects such as anticancer, antioxidant, and antibacterial properties [44,45].…”

Section: Discussionmentioning

confidence: 99%

Ultrahigh Pressure Processing Produces Alterations in the Metabolite Profiles of Panax ginseng

Lee

Singh

Kim³

et al. 2016

Molecules

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Ultrahigh pressure (UHP) treatments are non-thermal processing methods that have customarily been employed to enhance the quality and productivity of plant consumables. We aimed to evaluate the effects of UHP treatments on ginseng samples (white ginseng: WG; UHP-treated WG: UWG; red ginseng: RG; UHP-treated RG: URG; ginseng berries: GB; and UHP-treated GB: UGB) using metabolite profiling based on ultrahigh performance liquid chromatography-linear trap quadrupole-ion trap-tandem mass spectrometry (UHPLC-LTQ-IT-MS/MS) and gas chromatography time-of-flight mass spectrometry (GC-TOF-MS). Multivariate data analyses revealed a clear demarcation among the GB and UGB samples, and the phenotypic evaluations correlated the highest antioxidant activities and the total phenolic and flavonoid compositions with the UGB samples. Overall, eight amino acids, seven organic acids, seven sugars and sugar derivatives, two fatty acids, three notoginsenosides, three malonylginsenosides, and three ginsenosides, were identified as significantly discriminant metabolites between the GB and UGB samples, with relatively higher proportions in the latter. Ideally, these metabolites can be used as quality biomarkers for the assessment of ginseng products and our results indicate that UHP treatment likely led to an elevation in the proportions of total extractable metabolites in ginseng samples.

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“…The K b values of most compounds are similar or higher than that of the classical intercalator EB (K b ¼ 1.23 Â 10 5 M À1 ). 66,67 The promising results obtained from the DNA binding studies gave a root to think on the interaction of the compounds with DNA where the binding takes place via intercalative interaction.…”

Section: Dna Binding Studyabsorption Titrationmentioning

confidence: 99%

Synthesis, characterization and biological evaluation of cationic hydrazone copper complexes with diverse diimine co-ligands

Chew

Sinniah

et al. 2014

RSC Adv.

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Zinc complexes of salicylaldehydes: Synthesis, characterization and DNA-binding properties

Cited by 51 publications

References 44 publications

A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent

A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent

Ultrahigh Pressure Processing Produces Alterations in the Metabolite Profiles of Panax ginseng

Synthesis, characterization and biological evaluation of cationic hydrazone copper complexes with diverse diimine co-ligands

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