Zinc concentration in serum and cerebrospinal fluid simultaneously decrease in children with febrile seizure: Findings from a prospective study in Bangladesh

Mollah, Md. Abid Hossain; Rakshit, Sudesh Chandra; Anwar, Kazi Selim; Arslan, MI; Saha, Narayan Chandra; Ahmed, Shakil; Azad, K A; Hassan, Tariq

doi:10.1111/j.1651-2227.2008.01001.x

Cited by 34 publications

(34 citation statements)

References 11 publications

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“…In the current study, CSF to serum calcium ratio was low which may be explained by higher serum calcium level. The mean serum zinc level in our study was higher than other studies (11,13,19,23). The normal value for serum zinc level in our laboratory was considered 70 -200 μg/dL and no hypozincemia was detected.…”

Section: Discussioncontrasting

confidence: 51%

“…In some studies, CSF zinc levels in FS patients were significantly lower than control group (19)(20)(21)(22); whereas other studies revealed no significant difference in CSF zinc levels (14). Although, many investigations showed significantly lower level of serum zinc comparing to control group (12,19,22,23).…”

Section: Introductionmentioning

confidence: 94%

“…Although, many investigations showed significantly lower level of serum zinc comparing to control group (12,19,22,23). In some studies, serum zinc levels were within normal limit (24).…”

Section: Introductionmentioning

confidence: 99%

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The Correlation between Cerebrospinal Fluid and Levels of Serum Zinc and Calcium in Children With Febrile Seizure

et al. 2013

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Background: Febrile seizure (FS) is one of the most common neurological conditions in childhood. It seems that zinc and calcium deficiency are related to seizure activity. Objectives: The aim of the present study was to measure zinc and Calcium levels in the serum and cerebrospinal fluids of febrile convulsive children referred to Zanjan University, Valie Asr hospital. Patients and Methods: Three hundred and ten consecutive children with febrile seizure, who were admitted from January 2009 to December 2010, were studied. Forty five children required lumbar puncture based on the discretion of treating physician. Levels of zinc and calcium were measured in the serum and cerebrospinal fluid specimens of patients using atomic absorption spectrometry method. Results: The mean levels of serum calcium, serum zinc, cerebrospinal fluid calcium and cerebrospinal fluid zinc were 14.51 ± 3.69 mg/dL; 184.04 ± 65.49 µg/dL; 5.23 ± 2.21 mg/dL and 87.06 ± 28.25 µg/dL respectively. Conclusions: We did not find any clear abnormality in plasma or cerebrospinal fluid calcium and zinc levels in children with febrile seizures in our patient population.

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Section: Discussioncontrasting

confidence: 51%

Section: Introductionmentioning

confidence: 94%

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The Correlation between Cerebrospinal Fluid and Levels of Serum Zinc and Calcium in Children With Febrile Seizure

et al. 2013

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“…Clinical studies have also suggested an association between FSs and Zn 2+ levels. Mollah et al (16) reported that children with FSs had lower serum and CSF Zn 2+ levels compared to febrile children with no FSs. Seizuresensitive brain regions have high densities of zinc-containing neuronal terminals, and Zn 2+ plays well-known roles in transmission at glutamatergic, GABAergic, and glycinergic synapses.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, Zn 2+ deficiency parallels low GABA levels in cerebrospinal fluid (CSF), triggering seizures (8). Studies of the pathogenesis of febrile seizures (FSs), the most common type of seizure in children, found that Zn 2+ levels were low in both the serum and the CSF (16). The effect of Zn 2+ treatment in different experimental seizure models have been evaluated by Kumar H. et al (11).…”

Section: +mentioning

confidence: 99%

Zinc supplementation prolongs the latency of hyperthermia-induced febrile seizures in rats

Aydın¹,

Erdem²,

Yazici³

2016

Acta Physiologica Hungarica

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Some studies have shown a relationship between febrile seizures and zinc levels. The lowest dose zinc supplementation in pentylenetetrazole seizure model has a protective effect. But, zinc pretreatment has no effect in maximal electroshock model. However, it is unclear how zinc supplementation affects hyperthermia-induced febrile seizures. The aim of the present study was to investigate the effects of zinc supplementation on febrile seizures in male Sprague-Dawley rats. The rats were randomly assigned to four groups. Zinc supplementation was commenced 5 days prior to febrile seizure induction by placing the animals in a water bath at 45°C. We measured the rectal temperature and determined the febrile seizure latency, duration, and stage. In the zinc-supplemented group, both the seizure latency and the rectal temperature triggering seizure initiation were significantly higher than in the other groups. We suggest that zinc supplementation can positively modulate febrile seizure pathogenesis in rats.

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Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome

Lehotzky

Oláh

Szunyogh

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Tubulin Polymerization Promoting Protein/p25 (TPPP/p25), a neomorphic moonlighting protein displaying both physiological and pathological functions, plays a crucial role in the differentiation of the zinc-rich oligodendrocytes, the major constituent of myelin sheath; and it is enriched and co-localizes with α-synuclein in brain inclusions hallmarking Parkinson's disease and other synucleinopathies. In this work we showed that the binding of Zn(2+) to TPPP/p25 promotes its dimerization resulting in increased tubulin polymerization promoting activity. We also demonstrated that the Zn(2+) increases the intracellular TPPP/p25 level resulting in a more decorated microtubule network in CHO10 and CG-4 cells expressing TPPP/p25 ectopically and endogenously, respectively. This stabilization effect is crucial for the differentiation and aggresome formation under physiological and pathological conditions, respectively. The Zn(2+)-mediated effect was similar to that produced by treatment of the cells with MG132, a proteasome inhibitor or Zn(2+) plus MG132 as quantified by cellular ELISA. The enhancing effect of zinc ion on the level of TPPP/p25 was independent of the expression level of the protein produced by doxycycline induction at different levels or inhibition of the protein synthesis by cycloheximide. Thus, we suggest that the zinc as a specific divalent cation could be involved in the fine-tuning of the physiological TPPP/p25 level counteracting both the enrichment and the lack of this protein leading to distinct central nervous system diseases.

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Zinc concentration in serum and cerebrospinal fluid simultaneously decrease in children with febrile seizure: Findings from a prospective study in Bangladesh

Cited by 34 publications

References 11 publications

The Correlation between Cerebrospinal Fluid and Levels of Serum Zinc and Calcium in Children With Febrile Seizure

The Correlation between Cerebrospinal Fluid and Levels of Serum Zinc and Calcium in Children With Febrile Seizure

Zinc supplementation prolongs the latency of hyperthermia-induced febrile seizures in rats

Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome

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