Zinc-containing Mohs’ paste affects blood flow and angiogenesis suppression

Nagashima, Daichi; Furukawa, Megumi; Yamano, Yuko; Yamauchi, Takenori; Okubo, Shigeko; Toho, Masahiro; Ito, Yoshihisa; Izumo, Nobuo

doi:10.1007/s40199-021-00409-5

Cited by 4 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, high EGFR expression leads to resistance to radiotherapy [ 11 ]. It has been reported that Mohs' paste may suppress angiogenesis even at high levels of VEGF (vascular endothelial growth factor-A) [ 12 ]. Mohs' paste may be effective as a radiosensitizer by stopping this mechanism of radiation resistance.…”

Section: Discussionmentioning

confidence: 99%

A Case of Verrucous Carcinoma Treated by Combination of Radiotherapy and Mohs’ Chemosurgery

et al. 2022

View full text Add to dashboard Cite

Verrucous carcinoma (VC) is a rare subtype of squamous cell carcinoma. VC is histologically a benign tumor, but it grows significantly and eventually forms a huge mass. Many different treatments are known, but the first-line treatment is surgical resection. VC has strong local infiltration and frequently recurs, making its local control very difficult in unresectable cases. We present a rare case of VC that could be treated with combined radiotherapy and Mohs’ chemosurgery, as a new option for unresectable VC.

show abstract

Section: Discussionmentioning

confidence: 99%

A Case of Verrucous Carcinoma Treated by Combination of Radiotherapy and Mohs’ Chemosurgery

et al. 2022

View full text Add to dashboard Cite

show abstract

“…To understand the mechanism of action of coriander in oxidative stress-induced neurotoxicity, ERK and phosphorylated ERK levels were analyzed using western blotting. Samples (n=5 in each group) containing 10 µg cell protein were prepared as described in our previous study [13]. The protein extraction procedure is shown in Figure 1, and the details for each treatment group are shown in Table 2.…”

Section: Western Blot Analysismentioning

confidence: 99%

Effect of Coriander on H2O2-induced Oxidative Stress in PC12 Cells

Izumo¹

2022

J Clin Med Res

Self Cite

View full text Add to dashboard Cite

Objective: Coriander (Coriandrum sativum), a member of the Apiaceae family of plants, is traditionally used as a spice and medicinal plant which has anti-aging, anti-inflammatory, and anti-anxiety effects and is used for the treatment of diabetes. The present study aimed to investigate the effects of coriander on H2O2-induced neurotoxicity in PC12 cells. Methods: PC12 cells were cultured in Dulbecco’s modified Eagle’s medium, and the effects of various treatments were analyzed using cytotoxicity assay, morphological evaluation of neurite outgrowth, and western blotting. Results: The cytotoxicity assay showed increased levels of LDH in cells treated above 10-5 M H2O2, however there was no significant change in the coriander administration group. Morphological evaluation showed significantly increased neurite outgrowth in the nerve growth factor (NGF) treatment group after 72 h. Treatment of NGF-stimulated cells with H2O2 reversed the effect of NGF on neurite outgrowth, which returned to the levels of the control group. Simultaneous administration of H2O2, NGF and 0.1 or 0.01 µg/mL of coriander significantly increased neurite outgrowth after 72 h. Western blot showed that phosphorylated ERK levels were significantly increased in the NGF group compared with H2O2+NGF group, and no significant differences were found compared to the H2O2+NGF+0.1 µg/mL coriander administration group. Conclusion: Coriander reversed the reduction in neurite outgrowth following treatment of NGF-stimulated PC12 cells with H2O2. This suggests that coriander may help prevent oxidative stress-induced neurodegeneration.

show abstract