Zinc dampens anti-tumour immunity by promoting Foxp3+ regulatory T cells
Amit Awasthi,
Sugandha Narayan,
Rajdeep Dalal
et al.
Abstract:The role of zinc (Zn) in tumor development and immune modulation has always been paradoxical. This study redefines our understanding of the impact of Zn on cancer progression and therapeutic strategies. Our findings show that high dietary Zn promotes tumor progression by fostering a pro-tumorigenic environment mediated by T cells. In contrast, deficiency in dietary Zn and chelation of tissue Zn emerge as potent drivers of anti-tumor immunity. We elucidated that increased Zn intake facilitates tumor progression… Show more
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