Zinc deficiency and its association with treatment‐related toxicity in children with cancer

Chung, Jong Hee; Phalke, Neelam; Hastings, Caroline; Killilea, David W.; Feusner, James; Fung, Ellen B.

doi:10.1002/pbc.29104

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2024

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“…to increased viral infections and poorer outcomes. 12 Cardiomyopathy does occur in Se deficiency. 13 Whether low Se adds to anthracycline cardiomyopathy is unknown.…”

Section: Discussionmentioning

confidence: 99%

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Feasibility study of micronutrient status and body mass index of newly diagnosed pediatric oncology patients: Research commentary

Rogers,

Cheng,

Lim

et al. 2024

Pediatric Blood & Cancer

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We conducted a feasibility study to evaluate micronutrients and body mass index (BMI). Fat soluble vitamins A, D, E and trace elements copper (Cu), selenium (Se), and zinc (Zn) levels were evaluated. Weight, height, BMI, and Z‐scores were recorded. Side effects or specific adverse events were documented. No patient had a Z‐score for height, weight, or BMI of less than 2 SD or greater than 2 SD. Ninety percent of patients had one or more micronutrient levels below normal. These results suggest that micronutrient abnormalities are common despite no obvious evidence of malnutrition. Side effects of chemotherapy may be exacerbated by micronutrient depletion.

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“…to increased viral infections and poorer outcomes. 12 Cardiomyopathy does occur in Se deficiency. 13 Whether low Se adds to anthracycline cardiomyopathy is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D is the most frequently documented micronutrient associated with a poorer outcome 4–6,9–11 . Zn deficiency has been linked to increased viral infections and poorer outcomes 12 . Cardiomyopathy does occur in Se deficiency 13 .…”

Section: Discussionmentioning

confidence: 99%