Zinc Deficiency: Improvement in Growth and Growth Hormone Levels with Oral Zinc Therapy

Collipp, P.J.; Castro‐Magana, Mariano; Petrovic, Mihailo; Joseph, Thomas; Cheruvanky, Thulasi; Chen, Shang-Yao; Sussman, Howard H.

doi:10.1159/000176575

Cited by 39 publications

(12 citation statements)

References 11 publications

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“…On the other hand, some reports found increased GH response to pharmacological stimulation after Zn supplementation in Zn-deficient children [5,21,29,30] which was not the case in our study. Siklar et al [30] suggested that during GH treatment in GH deficient children, Zn status should be evaluated, as severe Zn deficiency could decrease the response to GH treatment which is improved with correction of Zn deficiency [30].…”

Section: Discussioncontrasting

confidence: 97%

Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency

2012

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BackgroundThe relationship between zinc (Zn) and growth hormone-insulin growth factor (GH-IGF) system and how Zn therapy stimulates growth in children has not been clearly defined in humans. Thus, we aimed to assess GH-IGF axis in short children with Zn deficiency and to investigate the effect of Zn supplementation on these parameters.MethodsFifty pre-pubertal Egyptian children with short stature and Zn deficiency were compared to 50 age-, sex-, and pubertal stage- matched controls. All subjects were subjected to history, auxological assessment and measurement of serum Zn, IGF-1, insulin growth factor binding protein-3 (IGFBP-3); and basal and stimulated GH before and 3 months after Zn supplementation (50 mg/day).ResultsAfter 3 months of Zn supplementation in Zn-deficient patients, there were significant increases in height standard deviation score (SDS, P = 0.033), serum Zn (P < 0.001), IGF-1 (P < 0.01), IGF-1 standard deviation score (SDS,P < 0.01) and IGFBP-3 (P = 0.042). Zn rose in all patients but reached normal ranges in 64 %, IGF-1 levels rose in 60 % but reached normal ranges in 40 % and IGFBP-3 levels rose in 40 % but reached reference ranges in 22 %. Growth velocity (GV) SDS did not differ between cases and controls (p = 0.15) but was higher in GH-deficient patients than non-deficient ones, both having Zn deficiency (p = 0.03).ConclusionSerum IGF-1 and IGFBP-3 levels were low in short children with Zn deficiency, and increased after Zn supplementation for 3 months but their levels were still lower than the normal reference ranges in most children; therefore, Zn supplementation may be necessary for longer periods.

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Section: Discussioncontrasting

confidence: 97%

Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency

2012

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“…Their diagnosis had been confirmed by the typical clinical course, characteristic physical findings, which included pelvifemoral weakness and calf pseudohypertrophy, family history, raised serum levels of creatinine kinase (CK), lactate dehydrogenase (LDH), and serum glutamate oxaloacetate transaminase (SGOT), and abnormal findings on muscle biopsy and electromyography. The ages of these nine children at the time of entry into the study were 5, 6,7,7,8,10,12,12, and 14 years.…”

Section: Methodsmentioning

confidence: 99%

Growth hormone inhibition causes increased selenium levels in Duchenne muscular dystrophy: a possible new approach to therapy.

Collipp¹,

Kelemen²,

Chen³

et al. 1984

Journal of Medical Genetics

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SUMMARY Nine children with Duchenne muscular dystrophy were given Sanorex (mazindol), a growth hormone inhibitor, daily for 6 months. There was no significant change in their muscle function, but there was a significant reduction in weight gain and in levels of growth hormone, somatomedin C, hair zinc, serum zinc, and serum LDH. Selenium and glutathione peroxidase in the serum increased significantly. Thirteen other children with growth hormone deficiency had a significant reduction in hair selenium following growth hormone administration.These results show a significant relationship between growth hormone and selenium nutritional status and confirm our previous reports indicating an effect of growth hormone on zinc nutritional status. It is possible that prolonged therapy with a growth hormone inhibitor would attenuate the course and improve the longevity of patients with muscular dystrophy.In a recent report of a family with Duchenne muscular dystrophy, an affected brother with growth hormone deficiency was substantially less disabled than his younger sibs.' Based on this observation, we decided to evaluate the effect of administering a growth hormone inhibitor to nine children with Duchenne muscular dystrophy. MethodsThe nine children studied had been followed for 1 to 9 years in our Muscular Dystrophy Clinic. Their diagnosis had been confirmed by the typical clinical course, characteristic physical findings, which included pelvifemoral weakness and calf pseudohypertrophy, family history, raised serum levels of creatinine kinase (CK), lactate dehydrogenase (LDH), and serum glutamate oxaloacetate transaminase (SGOT), and abnormal findings on muscle biopsy and electromyography. The ages of these nine children at the time of entry into the study were 5, 6, 7, 7, 8, 10, 12, 12, and 14 years.After a group discussion with all the parents, and individual discussions, a written informed consent *Supported in part by a grant from the Muscular Dystrophy Association, Nassau Chapter. Received for publication 21 October 1983. Accepted for publication 17 November 1983. was obtained for each child. The study was approved by our institutional research committee (IRB).Each child received Sanorex 8 (mazindol) at a dose of 2 mg daily for 6 months. Careful manual muscle testing and peak flow during forced expiration were done for each child at the beginning of the study and at 3 and 6 months by one of us (JK), and accurate measurements of height and weight were done by at least two of us at each examination. Laboratory tests were also performed at the beginning of the study and at 3 and 6 months. Human growth hormone was assayed in serum obtained before and 90 minutes after the oral administration of clonidine (0 1 to 0 2 mg). Selenium was assayed in serum and hair by the fluorometric method.2 Glutathione peroxidase, CK, LDH, and SGOT were assayed by standard methods. Hair and serum zinc were assayed by atomic absorption spectrophotometry. Somatomedin C was assayed by radioimmunoassay. Parents were instructed in the method o...

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“…Zinc is very important for human growth and zinc deficiency causes growth disturbance in children [1][2][3]. There have been some reports on the positive effects of oral zinc supplementation on height velocity in children with definite zinc deficiency [4,5], but in 1993, Nakamura et al conducted the first age-matched control study which showed that oral zinc supplementation was effective in improving the growth rate in short children [6].…”

Section: Introductionmentioning

confidence: 99%

Studies to Determine the Usefulness of the Zinc Clearance Test to Diagnose Marginal Zinc Deficiency and the Effects of Oral Zinc Supplementation for Short Children

Kaji

Gotoh

Takagi

et al. 1998

Journal of the American College of Nutrition

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Zinc Deficiency: Improvement in Growth and Growth Hormone Levels with Oral Zinc Therapy

Cited by 39 publications

References 11 publications

Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency

Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency

Growth hormone inhibition causes increased selenium levels in Duchenne muscular dystrophy: a possible new approach to therapy.

Studies to Determine the Usefulness of the Zinc Clearance Test to Diagnose Marginal Zinc Deficiency and the Effects of Oral Zinc Supplementation for Short Children

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