Zinc Deficiency is Associated with Poor Glycemic Control

Farooq, Muhammad

doi:10.29271/jcpsp.2019.03.253

Cited by 17 publications

(11 citation statements)

References 18 publications

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“…Zn is widely distributed in the human body and the most abundant Zn is in muscle (60%), followed by bone (20-30%), skin and hair (8%), and liver (4-6%) [20]. In many patients with LC, diabetes, chronic inflammatory bowel diseases, and chronic kidney diseases, serum Zn levels have been reduced, indicating that they are in a state of Zn deficiency [19,[21][22][23]. Hypozincemia (serum Zn level <55 µg/dL) has been linked to liver carcinogenesis in patients with hepatitis C virus (HCV)-related LC [24].…”

Section: Introductionmentioning

confidence: 99%

Serum Zinc Level Classification System: Usefulness in Patients with Liver Cirrhosis

Nishikawa

Enomoto

Iwata

et al. 2019

JCM

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Currently, the Japanese society of clinical nutrition (JSCN) defines serum zinc (Zn) level < 60 μg/dL as Zn deficiency and 60 μg/dL ≤ serum Zn level < 80 μg/dL as subclinical Zn deficiency, and 80 μg/dL ≤ serum Zn level < 130 μg/dL as normal Zn range. We aimed to elucidate the prognostic impact of this Zn classification system in patients with liver cirrhosis (LC) compared to the Child–Pugh classification and the albumin–bilirubin (ALBI) grading system (n = 441, median age = 66 years). The Akaike information criterion (AIC) with each evaluation method was tested in order to compare the overall survival (OS). The median serum Zn level was 65 μg/dL. There were 56 patients with normal Zn level, 227 with subclinical Zn deficiency and 158 with Zn deficiency. OS was well stratified among three groups of serum Zn level (p < 0.0001). The AIC value for survival by the Zn classification system was the lowest among three prognostic models (AIC: 518.99 in the Child–Pugh classification, 502.411 in ALBI grade and 482.762 in the Zn classification system). Multivariate analyses of factors associated with OS revealed that serum Zn classification by JSCN was an independent factor. In conclusion, the serum Zn classification proposed by JSCN appears to be helpful for estimating prognosis in LC patients.

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Section: Introductionmentioning

confidence: 99%

Serum Zinc Level Classification System: Usefulness in Patients with Liver Cirrhosis

Nishikawa

Enomoto

Iwata

et al. 2019

JCM

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“…Our patient was also a type 1 diabetic. Low serum zinc levels have been associated with poor glycemic control in both type 1 and 2 diabetics [20,21]. Zinc is a cofactor in the synthesis, storage, and secretion of insulin [20].…”

Section: Discussionmentioning

confidence: 99%

“…Low serum zinc levels have been associated with poor glycemic control in both type 1 and 2 diabetics [20,21]. Zinc is a cofactor in the synthesis, storage, and secretion of insulin [20]. In addition, since zinc is essential in the formation and function of antioxidant enzymes, zinc deficiency may result in an increase in intracellular oxidants and free radicals in diabetics [22].…”

Section: Discussionmentioning

confidence: 99%

Acquired Acrodermatitis Enteropathica in a 28-Year-Old Male with Type 1 Diabetes

Ngalamika

Selvaraj

Yikona³

et al. 2021

Case Reports in Dermatological Medicine

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Acrodermatitis enteropathica (AE) is a rare disorder arising from inherited or acquired zinc deficiency. It is mainly characterized by acral dermatitis, periorificial dermatitis, alopecia, and gastrointestinal symptoms in the form of diarrhea. There are many complications of AE including local and systemic infections that may develop as a result of untreated AE. In addition, due to the role of zinc in glucose metabolism, chronic zinc deficiency may pose a challenge in the control of blood glucose levels in diabetics. We report the case of a 28-year-old male with type 1 diabetes who presented with signs and symptoms of AE.

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“…In pancreatic beta-cells, oxidative stress is a central mechanism involved in the alteration of the beta-cell differentiated phenotype under chronic hyperglycemia [3,[54][55][56][57]. Moreover, metal ions play essential physiological roles in beta-cells, and metal dyshomeostasis has been linked with the beta-cell demise in experimental models and was associated with diabetes and its complications in human subjects [58][59][60][61][62][63]. Interestingly, several clinical and epidemiological reports have shown that both type 1 diabetes (T1D) and T2D states are characterized by hypozincemia [64][65][66][67][68][69].…”

Section: Metallothioneins: the Guardians Of Metal And Redox Homeostasismentioning

confidence: 99%

Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and above Metal Homeostasis and Antioxidant Response

Bensellam

Laybutt

Jonas

2021

Biology

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Metallothioneins (MTs) are low molecular weight, cysteine-rich, metal-binding proteins whose precise biological roles have not been fully characterized. Existing evidence implicated MTs in heavy metal detoxification, metal ion homeostasis and antioxidant defense. MTs were thus categorized as protective effectors that contribute to cellular homeostasis and survival. This view has, however, been challenged by emerging evidence in different medical fields revealing novel pathophysiological roles of MTs, including inflammatory bowel disease, neurodegenerative disorders, carcinogenesis and diabetes. In the present focused review, we discuss the evidence for the role of MTs in pancreatic beta-cell biology and insulin secretion. We highlight the pattern of specific isoforms of MT gene expression in rodents and human beta-cells. We then discuss the mechanisms involved in the regulation of MTs in islets under physiological and pathological conditions, particularly type 2 diabetes, and analyze the evidence revealing adaptive and negative roles of MTs in beta-cells and the potential mechanisms involved. Finally, we underscore the unsettled questions in the field and propose some future research directions.

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Zinc Deficiency is Associated with Poor Glycemic Control

Abstract: The sample size was calculated by using sample size calculating formula available on website 10 by keeping 95% confidence level and 5% margin of error for population of 1,00,000. The minimum sample size was 383 subjects.

Cited by 17 publications

References 18 publications

Serum Zinc Level Classification System: Usefulness in Patients with Liver Cirrhosis

Serum Zinc Level Classification System: Usefulness in Patients with Liver Cirrhosis

Acquired Acrodermatitis Enteropathica in a 28-Year-Old Male with Type 1 Diabetes

Emerging Roles of Metallothioneins in Beta Cell Pathophysiology: Beyond and above Metal Homeostasis and Antioxidant Response

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