Zinc Deficiency Suppresses Plasma Leptin Concentrations in Rats

Mangian, Heather; Lee, Rita G.; Paul, Gregory L.; Emmert, J. L.; Shay, Neil F.

doi:10.1016/s0955-2863(97)00165-4

Cited by 52 publications

(42 citation statements)

References 34 publications

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“…Although leptin was reduced in the plasma of the ZnD rats, lower body fat and decreased plasma insulin concentrations are correlated with lower concentration of leptin (24,25). Mangian et al suggested that Zn-deficiency decreased leptin levels, whereas Zn supplementation increased them (26). Reduced leptin levels indicated that leptin was responding normally, signaling low body fat levels during Zn-deficiency.…”

Section: Discussionmentioning

confidence: 99%

Zinc's Role in Rat Preference for a Low-Fat Diet in a Two-Choice Diet Program of Low- and High-Fat Diets

Nakashima

2011

J Nutr Sci Vitaminol

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SummaryTo investigate the change in preference for a low-fat diet (LFD) and a high-fat diet (HFD) under disorders induced by a zinc (Zn)-deficiency, two groups of 4-wk-old male rats were fed a two-choice diet of Zn-deficient (ZnD; 0.75 mg/kg) and Zn-adequate (ZnA; 30.75 mg/kg) LFD and HFD. After 21 d, 10 rats in each of the two groups were sacrificed. The remaining ZnD rats were switched to ZnA diets for 7 d. Intakes of the LFD and the HFD were measured to determine the diet preferences of the ZnD, the ZnA and the Zn-recovered groups. Energy intake of the ZnD group was significantly lower than that of the ZnA group and showed cyclical 3-to 4-d patterns of decrease. In the ZnD group, although the LFD intake decreased parallel to the reduction in the energy intake, the HFD intake did not show the cyclical pattern of decrease. The reduced intake of the LFD in the ZnD rats was accompanied by a low carbohydrate intake and a low plasma insulin concentration. When the ZnD group recovered sufficient amounts of Zn, the energy intake was restored to normal levels and the difference in the LFD intake and the plasma insulin concentration disappeared between the ZnD and the ZnA groups. It was supposed that the specific change in the LFD intake patterns during development and recovery from Zn-deficiency might be related to Znmediated changes in impaired synthesis and the release of insulin from the pancreas. Key Words zinc-deficiency, self-selection, preference for a low-fat diet, two-choice diet program, high-fat diet Zinc (Zn) is essential for animals and humans, and is required for many physiological functions. A Zn-deficiency in both animals and humans causes anorexia, a taste disorder, a poor appetite, impaired growth and dermatitis ( 1-3 ). Within 3 to 5 d after giving rats a Zndeficient (ZnD) diet, food intake is suppressed ( 3,4 ). This decrease in food intake is the first sign of Zn-deficiency, followed by other symptoms associated with Zndeficiency ( 3 ). Therefore, Zn may play an important role in the regulation of food intake.From a whole-body perspective, ZnD rats have significantly reduced body weight and carcass fat, and lower circulating leptin and insulin concentrations that play key roles in energy nutrient metabolism compared to the Zn-adequate (ZnA) rats ( 4-7 ). Leptin is produced by adipose tissue and has potent effects on body weight and food intake regulation. Another adiposity signal is insulin, which is the controller of blood glucose levels, and chronically high levels of insulin consequently lead to obesity ( 8 ). Arora and Anubhuti reported that leptin and insulin are ideal candidates for lipogenic function because their levels are closely related to adiposity, and their central administration decreases food intake ( 9 ). However, feeding is a complex behavior and the mechanisms by which Zn-deficiency induces anorexia are unclear. Zn-deficiency results in a reduction of food intake, suggesting that Zn status may affect the complex mechanisms underlying normal food intake.In a previous paper, we re...

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Section: Discussionmentioning

confidence: 99%

Zinc's Role in Rat Preference for a Low-Fat Diet in a Two-Choice Diet Program of Low- and High-Fat Diets

Nakashima

2011

J Nutr Sci Vitaminol

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“…Conversely, lower body fat, fasting, and decreased serum insulin concentrations are correlated with lower concentrations of leptin [27]. Mangian et al [28] showed that leptin was reduced in the serum of zincdeficient rats, which was not surprising, since anorexic rats have less body fat compared with controls.…”

Section: Zinc In Ckdmentioning

confidence: 99%

Zinc deficiency in Chronic Kidney Disease: Is there a Relationship with Adipose Tissue and Atherosclerosis?

Lobo

Torres

Fouque

et al. 2009

Biol Trace Elem Res

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Cardiovascular complications caused by an accelerated atherosclerotic disease consist the major cause of morbidity and mortality in patients with chronic kidney disease (CKD). These patients present multiple atherosclerotic risk factors, considered traditional, as well as nontraditional risk factors such as inflammation and oxidative stress. These complications are also seen in obesity, in which endothelial dysfunction is one of the early stages of atherosclerosis. The impact of trace metal deficiencies on this process is not well studied in patients with CKD and in obese people, although the influence of trace elements depletion, particularly zinc (Zn), may have significant clinical implications. This brief review describes the functions of Zn as well as the respective role of this trace element in atherosclerosis processes, with a particular emphasis on obese patients with chronic kidney disease.

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“…Its deficiency induces anorexia and is accompanied by a compensatory increased activity of central neuropeptide Y, a potent orexigenic agent (10). Thus, the distinct possibility exists that zinc status could influence the regulation of appetite and metabolism by influencing the leptin system (19). Low maternal zinc status has been associated with elevated milk copper concentrations and increased plasma copper levels in infants, suggesting that maternal zinc deficiency may affect mammary gland copper regulation (30).…”

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confidence: 99%

Correlation between birth weight, leptin, zinc and copper levels in maternal and cord blood

Özdemir

Gültürk

Aker

et al. 2007

J. Physiol. Biochem.

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Leptin and zinc are involved in the regulation of appetite. Copper is a trace element regulating the functions of several cuproenzymes that are essential for life. To evaluate the relationship between zinc and copper status and the leptin system in humans, we examined whether leptin concentrations in the mother and the newborn correlate with the weight of mother, placenta and newborn. A total of 88 pregnant women at 38-42 weeks' gestation were studied. All infants were categorized as small for gestational age (SGA) (n = 16), average for gestational age (AGA) (n = 59) or large for gestational age (LGA) (n = 13). Leptin, zinc, and copper levels were measured in maternal and cord serum at birth. Maternal BMI and placental weight of the LGA groups were significantly higher than those of the SGA and AGA groups. Cord and maternal leptin levels of the SGA groups were significantly lower than those of the AGA and LGA groups. Maternal serum leptin levels were positively correlated with BMI and maternal zinc levels in all groups. Cord serum leptin levels of all groups were positively correlated with birth weight and placental weight. Birth weight was negatively correlated with maternal and cord copper level of all groups. Umbilical leptin concentrations of SGA newborns correlated with leptin concentrations of their mothers. In all pregnancies, birth weight increases in association with increase in cord leptin level. Our results suggest that maternal zinc but not copper level has an effect on maternal serum leptin levels. The increase in copper level in both maternal and cord blood may contribute to restriction in fetal growth.

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Zinc Deficiency Suppresses Plasma Leptin Concentrations in Rats

Cited by 52 publications

References 34 publications

Zinc's Role in Rat Preference for a Low-Fat Diet in a Two-Choice Diet Program of Low- and High-Fat Diets

Zinc's Role in Rat Preference for a Low-Fat Diet in a Two-Choice Diet Program of Low- and High-Fat Diets

Zinc deficiency in Chronic Kidney Disease: Is there a Relationship with Adipose Tissue and Atherosclerosis?

Correlation between birth weight, leptin, zinc and copper levels in maternal and cord blood

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