With the aim of identifying the appropriate doses of Zinc in rice for different varieties under various establishment methods, an experiment was carried out in a strip-split plot design with three replications at Agriculture and Forestry University, Rampur, Chitwan during 2015-16. The treatment consists of two crop establishment methods (Transplanted rice (TPR) and Direct Seeded Rice (DSR)) in the vertical strip and two varieties (Hybrid Gorakhnath-509 and Sabitri) in the horizontal strip and four levels of ZnSO4 (0, 15, 30 and 45 kg ha-1) in sub-sub plot. The observations were recorded on growth, yield attributes, grain yield and economics. The research results revealed that the application of ZnSO4 @ 15 Kg ha-1 significantly increased the grain yield of DSR as compared to the non-application of ZnSO4. The higher grain yield of rice was because of increased yield attributes like effective tillers, thousand-grain weight and the number of filled grains per panicle. Crop establishment methods and varieties did not have a significant influence on the grain yield of rice. DSR had a lower cost of cultivation, higher net return and higher benefit-cost ratio as compared to TPR. The variety Sabitri had lower cost of cultivation, higher net return and higher benefit-cost ratio as compared to Gorakhnath-509. Similarly, the application of ZnSO4 @ of 15 Kg ha-1 produced the highest net return and the highest benefit-cost ratio. Therefore, ZnSO4 @ 15 kg ha-1 could be an option for increased yield and net return for DSR in Chitwan.