Zinc finger proteins in psychiatric disorders and response to psychotropic medications

Squassina, Alessio; Meloni, Anna; Chillotti, Caterina; Pisanu, Claudia

doi:10.1097/ypg.0000000000000231

Cited by 16 publications

(9 citation statements)

References 80 publications

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“…The functions of other members (NLRP8, -9, -11, -13) are still to be further investigated [18,22]. As is known, the zinc finger proteins (ZNFs) are the largest transcription factor family in human genome, which contain finger-like protrusions and play critical roles in physiological and pathophysiological mechanisms [26]. Previous research showed that duplications of zinc finger genes commonly occurred during the evolution [27].…”

Section: Discussionmentioning

confidence: 99%

Prenatal detection and molecular cytogenetic characterization of 19q13.42 microduplication: three reported cases and literature review

et al. 2021

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Background Trisomy 19q is a recognizable syndrome and associated with a wide spectrum of clinical phenotypes in clinic. The purpose of this study was to explore the prenatal phenotypes of 19q13.42 duplication, which was rarely reported in clinic. Case presentation Three pregnant women presenting diverse indications for prenatal diagnosis accepted amniocentesis: increased nuchal translucency and fetal pyelic separation (case 2) and high risk of maternal serum screening for Down syndrome (case 1 and case 3). Case 1 and case 2 shared similar duplicated locus in the region of 19q13.42, encompassing part NLRP12 gene. The latter inherited the chromosomal duplication from the mother with normal phenotypes. Case 3 carried a 1.445 Mb duplication in the 19q13.42q13.43 region. It was proposed that evolutionary duplication of NLRP12 gene could have a causative role in autoinflammatory diseases development. The genotype–phenotype correlation depends mainly on the duplicated size and functional genes involved, which is still yet to be determined. All pregnant women chose to continue the pregnancy and delivered healthy children with no apparent abnormalities. Conclusions The 19q13.42 microduplications in our study were the smallest fragments compared to previous literature. Our findings enriched the prenatal phenotypes for this chromosomal microscopic imbalance. It was proposed that long term follow up analysis should be guaranteed till adulthood to determine whether there will be other emerging clinical symptoms and developmental-behavioral disorders for such carriers.

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Section: Discussionmentioning

confidence: 99%

Prenatal detection and molecular cytogenetic characterization of 19q13.42 microduplication: three reported cases and literature review

et al. 2021

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“…PPI of ZNF804A, ZFP82, TRIM58, SOX17, and C12orf42 analyzed by the STRING database. (Squassina et al, 2019). Previous research has revealed that zinc finger proteins exert significant effects on cancer progression (Jen and Wang, 2016).…”

Section: Discussionmentioning

confidence: 99%

Aberrantly DNA Methylated-Differentially Expressed Genes in Pancreatic Cancer Through an Integrated Bioinformatics Approach

et al. 2021

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Pancreatic cancer remains one of the chief contributors to cancer related deaths on a global scale, with its diagnosis often associated with poor prognosis and high mortality. Accumulating literature continues to highlight the role of aberrant DNA methylation in relation to pancreatic cancer progression. Integrated bioinformatics approaches in the characterization of methylated-differentially expressed genes (MeDEGs) in pancreatic cancer were employed to enhance our understanding of the potential underlying molecular mechanisms of this cancer. We initially identified differentially expressed genes (DEGs) between 178 pancreatic cancer samples and 4 normal samples and differentially methylated genes (DMGs) based on 185 pancreatic cancer samples as well as 10 normal samples by analyzing RNA sequencing data in the TCGA database. Eventually, 31 MeDEGs including 5 hypomethylated/upregulated genes and 26 hypermethylated/downregulated genes were identified. Univariate Cox model and Kaplan–Meier method revealed that, among 31 MeDEGs, 5 hypermethylated/downregulated genes (ZNF804A, ZFP82, TRIM58, SOX17, and C12orf42) were correlated with poor survival of patients with pancreatic cancer. KEGG pathway enrichment analysis by GSEA 3.0 and the protein–protein interaction (PPI) network revealed that these 5 MeDEGs were enriched in numerous cancer-related pathways in addition to interacting with each other, highlighting a significant role in the development of pancreatic cancer. Taken together, the key findings of the current study demonstrate that ZNF804A, ZFP82, TRIM58, SOX17, and C12orf42 are hypermethylated/downregulated genes in pancreatic cancer and may be associated, through their modulation of specific pathways, with unfavorable pancreatic cancer prognosis.

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“…It has a repeating structure of amino acid patterns, and cystines separated by a specific distance bind zinc fingers, which can interact with certain RNA/ DNA binding [30]. Due to its own structural characteristics, zinc finger protein can selectively bind to specific target structures, so that the gene expression of zinc finger protein plays an important role in the regulation of cell differentiation, embryo development and other life processes [31]. According to the different conserved domains of zinc finger proteins, they can be divided into C2H2, C4 and C6 [32].…”

Section: Discussionmentioning

confidence: 99%

ZNF668: a new diagnostic predictor of kidney renal clear cell carcinoma

et al. 2021

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The most common pathological subtype of renal carcinoma is RCC, and its development is closely related to immune infiltration. In our study, we investigated the relationship between zinc finger protein 668 and the prognostic risk, clinical characteristics, overall survival and related pathways. We analyzed the association between ZNF668 and immune cell infiltration through the TIMER database. The results showed that the expression of ZNF668 in RCC was higher than that in normal tissues (P < 0.001). The high expression of ZNF668 is clinically relevant, such as tumor stage (P = 0.001) and TNM classification (T: P = 7.37 e-04; N: P = 0.008; M: P < 0.001). Survival analysis showed that patients with high ZNF668 expression had a significantly poor prognosis (P = 0.023). Univariate analysis showed a significant decrease in overall survival in RCC patients with high ZNF668 expression (P = 0.023). Immuno-cell infiltration showed a significant decrease in CD4 + T cell and dendritic cell infiltration in RCC patients with high expression of ZNF668. GO/KEGG analysis showed that multiple pathways were differentially enriched in the high expression pathway of ZNF668, such as complement activation, and estrogen signaling pathway. In conclusion, high ZNF668 expression is a predictor in RCC. Anti-Cancer Drugs 33: e491-e499

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Zinc finger proteins in psychiatric disorders and response to psychotropic medications

Cited by 16 publications

References 80 publications

Prenatal detection and molecular cytogenetic characterization of 19q13.42 microduplication: three reported cases and literature review

Prenatal detection and molecular cytogenetic characterization of 19q13.42 microduplication: three reported cases and literature review

Aberrantly DNA Methylated-Differentially Expressed Genes in Pancreatic Cancer Through an Integrated Bioinformatics Approach

ZNF668: a new diagnostic predictor of kidney renal clear cell carcinoma

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