Zinc for the common cold

Singh, Meenu; Das, Rashmi Ranjan

doi:10.1002/14651858.cd001364.pub5

Cited by 33 publications

(27 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Treatments such as zinc-containing products are now widely discredited as demonstrated by the withdrawal of a Cochrane report and JAMA editorial [43][44][45].…”

Section: Rhinovirus (The "Common" Cold)mentioning

confidence: 99%

The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics

et al. 2018

View full text Add to dashboard Cite

The Human Viral Challenge (HVC) model has, for many decades, helped in the understanding of respiratory viruses and their role in disease pathogenesis. In a controlled setting using small numbers of volunteers removed from community exposure to other infections, this experimental model enables proof of concept work to be undertaken on novel therapeutics, including vaccines, immunomodulators and antivirals, as well as new diagnostics.Crucially, unlike conventional phase 1 studies, challenge studies include evaluable efficacy endpoints that then guide decisions on how to optimise subsequent field studies, as recommended by the FDA and thus licensing studies that follow. Such a strategy optimises the benefit of the studies and identifies possible threats early on, minimising the risk to subsequent volunteers but also maximising the benefit of scarce resources available to the research group investing in the research. Inspired by the principles of the 3Rs (Replacement, Reduction and Refinement) now commonly applied in the preclinical phase, HVC studies allow refinement and reduction of the subsequent development phase, accelerating progress towards further statistically powered phase 2b studies. The breadth of data generated from challenge studies allows for exploration of a wide range of variables and endpoints that can then be taken through to pivotal phase 3 studies.We describe the disease burden for acute respiratory viral infections for which current conventional development strategies have failed to produce therapeutics that meet clinical need. The Authors describe the HVC model’s utility in increasing scientific understanding and in progressing promising therapeutics through development.The contribution of the model to the elucidation of the virus-host interaction, both regarding viral pathogenicity and the body’s immunological response is discussed, along with its utility to assist in the development of novel diagnostics.Future applications of the model are also explored.Electronic supplementary materialThe online version of this article (10.1186/s12931-018-0784-1) contains supplementary material, which is available to authorized users.

show abstract

“…Treatments such as zinc-containing products are now widely discredited as demonstrated by the withdrawal of a Cochrane report and JAMA editorial [43][44][45].…”

Section: Rhinovirus (The "Common" Cold)mentioning

confidence: 99%

The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In contrast to this widespread use, there is very little evidence to recommend any such measures. In particular with regard to cancer patients, evidence is too poor to give a sound recommendation in favour of the use of vitamin C [50], echinacea [51], garlic [52], zinc [53], humidified hot air [54] or Chinese herbal medicine [55]. Surprisingly, even painkillers [56] and non-steroidal anti-inflammatory drugs [57] may ease the pain but have little influence on severity and duration of the CRV infection.…”

Section: Supportive Measuresmentioning

confidence: 99%

Community acquired respiratory virus infections in cancer patients—Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology

Lilienfeld‐Toal

Berger

Christopeit

et al. 2016

European Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Supplements studied thus far in human athletes include herbal extracts (for example, Echinacea), plant sterols, polyphenols (for example, quercetin) and polysaccharides (for example, β-glucans), omega-3 polyunsaturated fatty acids, glutamine, branched-chain amino acids, bovine colostrum and zinc. Although some supplements (for example, zinc 32 and some herbals such as Kaloba 33 ) may reduce the duration or severity of illness episodes if taken close to the onset of symptoms, generally the results have been disappointing with regard to reducing infection incidence (Table 1). However, there is emerging evidence that probiotics, colostrum and plant polyphenols may provide some protective benefit against infection.…”

Section: Other Supplements To Support Immunity For Athletesmentioning

confidence: 99%

Immunological aspects of sport nutrition

Gleeson

2015

Immunol Cell Biol

View full text Add to dashboard Cite

Prolonged bouts of exercise and heavy training regimens are associated with depression of immune system functions which can increase the risk of picking up opportunistic infections such as the common cold and influenza. Some common sport nutrition practices including high carbohydrate diets and carbohydrate ingestion during exercise, training with low glycogen stores, intentional dieting for weight loss, ingestion of high dose antioxidant supplements and protein ingestion post-exercise may influence immune system status in athletes. In order to maintain robust immunity, athletes need to consume a well-balanced diet that is sufficient to meet their requirements for energy, carbohydrate, protein, and micronutrients. Dietary deficiencies of protein and specific micronutrients are well known to be potential causes of immune dysfunction and an adequate intake of some essential minerals including iron and zinc and the vitamins A, D, E, B6 and B12 are important to maintain a healthy immune function. Vitamin D may be a particular concern as recent studies have emphasised its importance in limiting infection episode incidence and duration in both the general population and in athletes and many individuals exhibit inadequate vitamin D status during the winter months. There is only limited evidence that individual amino acids, -glucans, herbal extracts and zinc are capable of boosting immunity or reducing infection risk in athletes. The ingestion of carbohydrate during exercise and daily consumption of probiotics, vitamin D3, bovine colostrum, and plant polyphenol containing supplements or foodstuffs currently offer the best chance of success, particularly for those individuals who are prone to illness.

show abstract

Zinc for the common cold

Abstract: The editorial group responsible for this previously published document have withdrawn it from publication.

Cited by 33 publications

References 48 publications

The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics

The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics

Community acquired respiratory virus infections in cancer patients—Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology

Immunological aspects of sport nutrition

Contact Info

Product

Resources

About