Zinc(II) and copper(II) complexes of β-substituted hydroxylporphyrins as tumor photosensitizers

A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt(II), Zn(II), Cu(II), and Co(III) Complexes with N‐heteroaromatic Schiff Base (E)‐2‐[N′‐(1‐pyridin‐2‐yl‐ethylidene)hydrazino]acetate

“…Also, the role of zinc in nucleic acid chemistry is unique in many aspects . Contrary to the wide range of biomedical applications , little data on cytotoxic properties of Zn(II) complexes are available , although Zn(II) complexes have recently gained attention as promising alternatives to platinum‐based anticancer drugs . Copper is a required cofactor for a variety of enzymes and proteins involved in numerous processes such as redox metabolism, oxidative phosphorylation, and DNA synthesis .…”

Ionic Liquid-Based Chlorins and Type III Mechanism of Photodynamic Therapy (PDT)

“…219 Some transition metal complexes were developed in PDT as good candidates of PS containing metalloporphyrin, [221][222][223] metallochlorin, 224,225 metallobacteriochlorin, [226][227][228] and metallophthalocyanine 229,230 derivatives. Addition of a transition metal (heavy atom) generally increases the efficiency of the singlet-triplet intersystem crossing (the so-called heavy atom effect) due to the enhanced spin-orbital perturbations, 231 which results in an increased efficacy in PDT corresponding to an improvement of the singlet oxygen quantum yield.…”

Fluorescence sensor for sequential detection of zinc and phosphate ions

“…Zn 2+ ions are also an essential component of many enzymes, e.g., carbonic anhydrase, transcription factors, and zinc finger proteins, in which they play catalytic or structural roles [15]. Clinically, diverse Zn 2+ -based compounds have been used as tumor photosensitizers [16], antibacterial/antimicrobial and anticancer agents [17], radioprotective agents [18], and antidiabetic insulin mimetics [19]. Moreover, the hepato and cardio toxicity induced by some anticancer drugs can be reduced by Zn 2+ [20].…”