Zinc(II) tweezers containing artificial peptides mimicking the active site of phosphotriesterase: The catalyzed hydrolysis of the toxic organophosphate parathion

Synthesis and spectroscopic characterization of zinc(II) and copper(II) complexes of N,N-bis(2-picolyl)glycine as structural phosphotriestrase models: The catalyzed detoxification of paraoxon

“…6) displayed bell-shaped curves at pH 8.5. This phenomenon is similar to the characters of natural enzymes [26][27][28][29][30]54,55]. Interestingly, the rate maximums of p-NPDEP hydrolysis catalyzed Table 5 Kinetic parameters using the Coats-Redfern (CR) and Horowitz-Metzger (HM) operated for [BPG-Cu(H 2 O) 2 ](NO 3 ) 3.…”

“…A program is in progress in our laboratory to study biomimetic hydrolytic metalloenzymes [26][27][28][29][30][31][32][33][34][35][36]. The aim of the present work, and in a continuation of our program, is to synthesize the heteroscorpinate ligand N,N-bis(2-picolyl)glycine, BPG-H, in its free state.…”

Increasing the histidine ‘density’ in tripodal peptides by gradual N -functionalization of tris (2-aminoethyl)amine (tren) with l -histidyl units: The effect on zinc(II) complexes

“…Tripodal peptidomimetics have been receiving increasing interest in the last decades in order to create chiral receptor molecules [1,2], triple helical biomimetic materials [3], peptide-like dendrimers for e.g. drug delivery [4], organic catalysts [4] or metal ion chelators [5][6][7][8][9][10][11][12]. The metal ion binding properties of tripodal peptidomimetics can differ significantly from those of linear peptides.…”

“…By adequate substitution of the tripodal platform, it is relatively easy to fine-tune the (i) metal ion binding ability, (ii) the electronic structure and steric environment of the metal centers, and (iii) the nuclearity of the forming complexes. Indeed, by varying the substituents of the tripodal platforms, such ligands form both mono- [5][6][7][8][9][10][11][12] and oligonuclear [7,8,[10][11][12] complexes, and provide tight binding for a range of metal ions, from Cu(I) [8], Cu(II) [9,12], Zn(II) [7,10,11] to Fe(III) [6].…”

“…Metal binding tripodal peptidomimetics can be strong metal ion sequestering agents [6][7][8] or may form efficient artificial metalloenzymes [9][10][11][12].…”