Zinc Imidazolate Metal–Organic Frameworks-8-Encapsulated Enzymes/Nanoenzymes for Biocatalytic and Biomedical Applications

Issaka, Eliasu; Amu-Darko, Jesse Nii Okai; Adams, Mabruk; Yakubu, Salome; Gyimah, Eric; Ali, Nisar; Cui, Jiandong; Bilal, Muhammad

doi:10.1007/s10562-022-04140-x

Cited by 28 publications

(7 citation statements)

References 144 publications

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“…At more than 50 mg, the active site of the enzyme was masked due to the accumulation of excessive enzyme, resulting in the weakened enzyme effective contact with the substrate. 35 Fig. 3e demonstrates that the embedding amount of single and dual enzymes was similar in H-Cu-BDC.…”

Section: Reaction Chemistry and Engineering Papermentioning

confidence: 77%

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Construction of a hollow MOF with high sedimentation performance and co-immobilization of multiple-enzymes for preparing rare ginsenoside CK

Cao¹,

Li²,

Tian³

et al. 2023

React. Chem. Eng.

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Section: Reaction Chemistry and Engineering Papermentioning

confidence: 77%

“…At more than 50 mg, the active site of the enzyme was masked due to the accumulation of excessive enzyme, resulting in the weakened enzyme effective contact with the substrate. 35…”

Section: Resultsmentioning

confidence: 99%

Construction of a hollow MOF with high sedimentation performance and co-immobilization of multiple-enzymes for preparing rare ginsenoside CK

Cao¹,

Li²,

Tian³

et al. 2023

React. Chem. Eng.

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“…Anti-inflammatory cytokines are molecules that reduce inflammation and help the stem cells to modulate their function, which means they can change their behavior according to the situation. 20,[39][40][41][42][43] Radiochemotherapy ZIF-8 can be modified with drugs that can enhance their delivery and effectiveness in radiotherapy. For example, Du et al designed a novel drug delivery system, [Dbait-ADM@ ZIF-8]OPM, which uses osteosarcoma-platelet hybrid membranes to encapsulate ZIF-8 coated with Dbait and Adriamycin.…”

Section: Stem Cell Therapymentioning

confidence: 99%

Section: Understanding Zif-8 As a Versatile Nanoparticle For Drug Del...mentioning

confidence: 99%

A new era in cancer treatment: harnessing ZIF-8 nanoparticles for PD-1 inhibitor delivery

Rastin,

Oryani,

Iranpour

et al. 2024

J. Mater. Chem. B

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“…5 In the same year, the Fujian Institute of Microbiology discovered and isolated CsA from another cyclosporine-producing fungus, Fusarium Solan, in Chinese soil. 5 In terms of physical and chemical characteristics, 6 as well as spectral detection, 4 the CsA isolated from Fusarium solanacearum and the foreign CsA were identical. 7 In 1991, China released the first CsA preparation that it had created independently.…”

Section: Introductionmentioning

confidence: 98%

A Multi-step High-Performance Liquid Chromatography (HPLC) Technique for the Extraction and Purification of Medical-Grade Cyclosporine A

Issaka,

Amu-Darko,

Adams

et al. 2024

Fine Chemical Engineering

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Cyclosporine A (CsA), a potent immunosuppressive drug, is used to treat autoimmune diseases and prevent organ transplant recipients from rejecting their new organs. Maintaining CsA's uniformity and purity is essential to maintaining its therapeutic efficacy and safety. Impurities and contaminants in CsA formulations can exacerbate side effects and patient toxicity. Purification processes can improve the safety profile of the drug and reduce the likelihood of adverse effects by eliminating impurities. Using High-performance liquid chromatography (HPLC) methods, CsA has been isolated and refined from crude in recent years. However, after the procedure, the CsA purity was not at its best. To solve this issue, this work employs a multi-step HPLC method to increase purity levels to above 95%. When exploring the HPLC detection conditions of CsA, we found that the method from the Chinese pharmacopoeia: acetonitrile-water-tert-butyl methyl ether-phosphoric acid (430 : 520 : 50 : 1) was a better mobile phase solution, our further research, including the substitution of tert-butyl methyl ether with other buffer solvents, showed no significant improvement. At the same time, we established that the key factor affecting its separation was temperature. When the temperature is lower than 70 ℃, the HPLC separation effect worsens, the retention time increases, and the peak width becomes longer. Finally, the utilization of acetonitrile-water-tert-butyl methyl ether-phosphoric acid (430 : 520 : 50 : 1) as the mobile phase with a column temperature of 70 °C, petroleum ether: acetic acid Ethyl ester (70 : 30) as the mobile phase, and filling the φ 40 mm × 500 mm chromatography column using a 40~60 μm silica gel so that a 10 : 1 height-to-diameter ratio of the packed part is obtained, under normal temperature conditions, resulted in an average cyclosporine A yield of 80.1%. The corresponding average purity was 97.2%, of which the first isolation yield was 82.3%, and the purity was 98.1%.

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Zinc Imidazolate Metal–Organic Frameworks-8-Encapsulated Enzymes/Nanoenzymes for Biocatalytic and Biomedical Applications

Cited by 28 publications

References 144 publications

Construction of a hollow MOF with high sedimentation performance and co-immobilization of multiple-enzymes for preparing rare ginsenoside CK

Construction of a hollow MOF with high sedimentation performance and co-immobilization of multiple-enzymes for preparing rare ginsenoside CK

A new era in cancer treatment: harnessing ZIF-8 nanoparticles for PD-1 inhibitor delivery

A Multi-step High-Performance Liquid Chromatography (HPLC) Technique for the Extraction and Purification of Medical-Grade Cyclosporine A

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