Zinc in depression: From development to treatment: A comparative/ dose response meta-analysis of observational studies and randomized controlled trials

Yosaee, Somaye; Clark, Cain C. T.; Keshtkaran, Zahra; Ashourpour, Mahkameh; Keshani, Parisa; Soltani, Sepideh

doi:10.1016/j.genhosppsych.2020.08.001

Cited by 30 publications

(23 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, unregulated zinc release at glutamatergic synapses following traumatic brain injury (TBI), ischemia, and seizures has been implicated in excitotoxic damage and death of postsynaptic neurons [ 18 , 31 , 32 , 33 , 34 ]. Zinc dysregulation has been linked to increased risk for depression [ 35 , 36 ] and has been implicated in several neurodegenerative diseases, including Alzheimer’s disease (AD) [ 37 , 38 , 39 , 40 , 41 , 42 ], amyotrophic lateral sclerosis (ALS) [ 43 , 44 ], and Parkinson’s Disease (PD) [ 34 , 45 , 46 , 47 ]. Intracellular zinc concentrations are normally maintained at tightly controlled levels by a surprisingly large collection of fourteen SLC39a Zrt-/Irt-like protein transporters (ZIPs) and at least ten SLC30a zinc transporters (ZnTs), which transfer zinc into and out of the cytosol, respectively [ 1 , 48 , 49 , 50 ].…”

Section: Introductionmentioning

confidence: 99%

The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction

Liu

Gale

Reynolds³

et al. 2021

Biomedicines

View full text Add to dashboard Cite

Zinc is a highly abundant cation in the brain, essential for cellular functions, including transcription, enzymatic activity, and cell signaling. However, zinc can also trigger injurious cascades in neurons, contributing to the pathology of neurodegenerative diseases. Mitochondria, critical for meeting the high energy demands of the central nervous system (CNS), are a principal target of the deleterious actions of zinc. An increasing body of work suggests that intracellular zinc can, under certain circumstances, contribute to neuronal damage by inhibiting mitochondrial energy processes, including dissipation of the mitochondrial membrane potential (MMP), leading to ATP depletion. Additional consequences of zinc-mediated mitochondrial damage include reactive oxygen species (ROS) generation, mitochondrial permeability transition, and excitotoxic calcium deregulation. Zinc can also induce mitochondrial fission, resulting in mitochondrial fragmentation, as well as inhibition of mitochondrial motility. Here, we review the known mechanisms responsible for the deleterious actions of zinc on the organelle, within the context of neuronal injury associated with neurodegenerative processes. Elucidating the critical contributions of zinc-induced mitochondrial defects to neurotoxicity and neurodegeneration may provide insight into novel therapeutic targets in the clinical setting.

show abstract

Section: Introductionmentioning

confidence: 99%

The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction

Liu

Gale

Reynolds³

et al. 2021

Biomedicines

View full text Add to dashboard Cite

show abstract

“…We found meta-analyses focusing on the following exposures or interventions: alternate healthy eating index (AHEI) or AHEI-2000 [ 21 ], vegetarian diet [ 22 ], dietary inflammatory index (DII) [ 23 ], Mediterranean diet [ 24 ], healthy dietary pattern [ 25 , 26 ], western diet [ 27 ], very low-calorie diet [ 28 ], and ultra-processed foods [ 29 ], cocoa-rich foods [ 30 ], red or processed meat [ 31 ], alcohol drink [ 32 ], sugar-sweetened beverages (SSBs) [ 33 ], fish [ 34 ], fruits [ 35 ], vegetables [ 35 ], coffee [ 36 ], tea [ 37 ], caffeine [ 38 ], prebiotics [ 39 ], probiotics [ 39 ], and dietary zinc [ 40 ], dietary magnesium [ 41 ], n-3 PUFA [ 42 – 44 ], acetyl- l -carnitine (ALC) [ 45 ], as well as vitamin D [ 46 ], folic acid [ 47 ], and total B vitamins [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

Role of dietary factors in the prevention and treatment for depression: an umbrella review of meta-analyses of prospective studies

Zeng

Zou

et al. 2021

Transl Psychiatry

View full text Add to dashboard Cite

The role of diet in depression is becoming increasingly acknowledged. This umbrella review aimed to summarize comprehensively the current evidence reporting the effects of dietary factors on the prevention and treatment of depression. PubMed, Embase, and the Cochrane Library were searched up to June 2021 to identify relevant meta-analyses of prospective studies. Twenty-eight meta-analyses, with 40 summary estimates on dietary patterns (n = 8), food and beverages (n = 19), and nutrients (n = 13) were eligible. The methodological quality of most meta-analyses was low (50.0%) or very low (25.0%). Quality of evidence was moderate for inverse associations for depression incidence with healthy diet [risk ratio (RR): 0.74, 95% confidential interval (CI), 0.48–0.99, I2 = 89.8%], fish (RR: 0.88, 95% CI, 0.79–0.97, I2 = 0.0%), coffee (RR: 0.89, 95% CI, 0.84–0.94, I2 = 32.9%), dietary zinc (RR: 0.66, 95% CI 0.50–0.82, I2 = 13.9%), light to moderate alcohol (<40 g/day, RR: 0.77, 95% CI, 0.74–0.83, I2 = 20.5%), as well as for positive association with sugar-sweetened beverages (RR: 1.05, 95% CI, 1.01–1.09, I2 = 0.0%). For depression treatment, moderate-quality evidence was identified for the effects of probiotic [standardized mean difference (SMD): −0.31, 95% CI, −0.56 to −0.07, I2 = 48.2%], omega-3 polyunsaturated fatty acid (SMD: −0.28, 95% CI, −0.47 to −0.09, I2 = 75.0%) and acetyl-l-carnitine (SMD: −1.10, 95% CI, −1.65 to −0.56, I2 = 86.0%) supplementations. Overall, the associations between dietary factors and depression had been extensively evaluated, but none of them were rated as high quality of evidence, suggesting further studies are likely to change the summary estimates. Thus, more well-designed research investigating more detailed dietary factors in association with depression is warranted.

show abstract

“…So far, many analyses and studies investigating the relationship between Zn and depression have been carried out [ 114 , 115 , 116 ]. Undoubtedly, as confirmed by some researchers, regular and appropriate dosage of Zn reduces the symptoms and disorders caused by depression [ 117 ]. Interestingly, the improvement of patients’ health due to administration Zn was also observed in the absence of anti-depression drugs.…”

Section: Antioxidants As the Prevention And Treatment Of Depression And Admentioning

confidence: 97%

“…Interestingly, the improvement of patients’ health due to administration Zn was also observed in the absence of anti-depression drugs. The highest level of Zn intake during a study was correlated with the highest (about 28%) reduction of the risk of depression [ 117 ]. It is also suggested that Zn has the most effective and mild approach in terms of moderating depression.…”

Section: Antioxidants As the Prevention And Treatment Of Depression And Admentioning

confidence: 99%

Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer’s Disease: The Role of Antioxidants in Prevention and Treatment

et al. 2021

View full text Add to dashboard Cite

There is a growing body of scientific research showing the link between depression and dementia in Alzheimer’s disease (AD). The chronic stress contributes to the formation of oxidative stress in the parts of the brain involved in the development of depression and AD. The scientific literature reports the significant role of antioxidants, which are highly effective in treating these diseases. In this review, we have summarized the relationship between chronic stress, oxidative stress, and the changes in the brain they cause occurring in the brain. Among all the compounds showing antioxidant properties, the most promising results in AD treatment were observed for Vitamin E, coenzyme Q10 (CoQ10), melatonin, polyphenols, curcumin, and selenium. In case of depression treatment, the greatest potential was observed in curcumin, zinc, selenium, vitamin E, and saffron.

show abstract

Zinc in depression: From development to treatment: A comparative/ dose response meta-analysis of observational studies and randomized controlled trials

Cited by 30 publications

References 58 publications

The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction

The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction

Role of dietary factors in the prevention and treatment for depression: an umbrella review of meta-analyses of prospective studies

Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer’s Disease: The Role of Antioxidants in Prevention and Treatment

Contact Info

Product

Resources

About