Zinc in gastrointestinal and liver disease

Faa, Gavino; Nurchi, Valeria Marina; Ravarino, Alberto; Fanni, Daniela; Nemolato, Sonia; Gerosa, Clara; Eyken, Peter Van; Geboes, Karel

doi:10.1016/j.ccr.2007.09.024

Cited by 67 publications

(46 citation statements)

References 143 publications

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“…In particular, it has been shown that administration of zinc oxide nanoparticles results in primary accumulation of zinc in liver as compared to other parenchymatous organs (Baek et al, 2012). Moreover, the obtained data conform to the role of liver as a key organ in zinc homeostasis (Faa et al, 2008).…”

Section: Discussionmentioning

confidence: 69%

Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

Skalny

Tinkov

Medvedeva

et al. 2015

Acta Sci Pol Technol Aliment

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Background.A signifi cant association between Zn and Se homeostasis exists. At the same time, data on the infl uence of zinc supplementation on selenium distribution in organs and tissues seem to be absent. Therefore, the primary objective of the current study is to investigate the infl uence of zinc asparaginate supplementation on zinc and selenium distribution and serum superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in Wistar rats. Material and methods. 36 rats were used in the experiment. The duration of the experiment was 7 and 14 days in the fi rst and second series, respectively. The rats in Group I were used as the control ones. Animals in Groups II and III daily obtained zinc asparaginate (ZnA) in the doses of 5 and 15 mg/kg weight, respectively. Zinc and selenium content in liver, kidneys, heart, muscle, serum and hair was assessed using inductively coupled plasma mass spectrometry. Serum SOD and GPx activity was analysed spectrophotometrically using Randox kits. Results. Intragastric administration of zinc asparaginate signifi cantly increased liver, kidney, and serum zinc content without affecting skeletal and cardiac muscle levels. Zinc supplementation also stimulated selenium retention in the rats' organs. Moreover, a signifi cant positive correlation between zinc and selenium content was observed. Finally, zinc asparaginate treatment has been shown to modulate serum GPx but not SOD activity. Conclusion. The obtained data indicate that zinc-induced increase in GPx activity may be mediated through modulation of selenium status. However, future studies are required to estimate the exact mechanisms of zinc and selenium interplay.

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Section: Discussionmentioning

confidence: 69%

Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

Skalny

Tinkov

Medvedeva

et al. 2015

Acta Sci Pol Technol Aliment

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“…It is known that zinc have protective effects against free radical injury, lipid peroxidation, and cell membrane structure [4]. Zinc is a structural part of SOD which is an important element of antioxidant enzymes against ROS attack and lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

“…It is an essential element in many physiological functions including growth, immune response, reproduction, and antioxidant defense [1][2][3][4]. In addition, zinc plays an important role in pregnancy, bone growth, milk production, and egg production [5,6].…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Zinc and l-Arginine Supplementation on Total Antioxidants Capacity, Lipid Peroxidation, Nitric Oxide, Egg Weight, and Blood Biochemical Values in Japanase Quails

Atakisi

Atakişi

Kart

2009

Biol Trace Elem Res

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The aim of this study was to evaluate effects of dietary zinc and L-arginine supplementation on blood total antioxidant capacity (TAC), malondialdehyde (MDA), nitric oxide (NO), some blood chemistry parameters, and egg weights of laying quails. Three groups of Japanese quails were fed with a diet containing L-arginine (5 mg/kg), zinc (60 mg/kg), and normal basal diet (control) for 30 days. TAC, lipid peroxidation, and biochemical analysis were performed in the blood of animals. L-Arginine and zinc supplementation improved TAC and reduced MDA concentrations compared to the control (P<0.05). In comparison to the control, blood NO concentrations were increased by Larginine (P<0.01) and zinc treatment (P<0.05). Both zinc (P<0.001) and L-arginine (P< 0.01) supplementation significantly increased egg weight in laying quails. Some of the blood chemistry parameters were also altered by the treatment of L-arginine and zinc supplementation. No difference was found in blood albumin and creatinine levels among the groups. Blood glucose (P=0.833) and total protein (P=0.264) levels in control and Larginine-treated groups were found to be similar. Glucose and total protein levels were decreased in zinc-supplemented animals compared to the control and L-arginine groups (P< 0.05). No difference was found in triglyceride levels between control and zinc-applied groups (P=0.197). However, L-arginine treatment reduced the blood triglyceride levels compared to the control (P<0.05). In conclusion, L-arginine and zinc supplementation could be beneficial and effective for decreasing oxidative stress, boosting antioxidant capacity, and improving egg weight in the blood of the animals.

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“…In this study, we confirm the findings by Zang and Guo (2009) but we also explain the increased expression of TJ proteins as a consequence of reduced local inflammation. In fact, other authors suggest that Zn may halt the progression of gastrointestinal disease by halting the inflammatory process (Faa et al, 2008), but, despite the anti-inflammatory effect that we observed in this study could be generally attributable to Zn from ZnO, regardless of the source, the TJ protein structure was clearly modulated in a source-dependent way, as demonstrated by the relative abundance of both occludin and ZO-1, which were higher in mZnO-800 than in pZnO. Although reasons for this are not clear at the moment, some contribution might derive form the microencapsulation itself.…”

Section: Discussionmentioning

confidence: 99%

Low doses of microencapsulated zinc oxide improve performance and modulate the ileum architecture, inflammatory cytokines and tight junctions expression of weaned pigs

Grilli

Tugnoli

Vitari

et al. 2015

Animal

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The aim of this study was to compare low doses of microencapsulated v. pharmacological ZnO in the diet of piglets on growth performance, ileum health status and architecture. One hundred and forty-four piglets weaned at 28 days and divided in 36 pens (two males and two females per pen), received a basal diet (control, Zn at 50 mg/kg) or the basal diet with ZnO at 3000 mg/kg (pZnO), or with lipid microencapsulated ZnO at 150 or 400 mg/kg (mZnO-300 and mZnO-800, respectively). After 14 and 42 days, three pigs per sex per treatment were euthanized to collect the ileum mucosa for immunohistochemistry, histomorphology, inflammatory cytokines and tight junction components gene expression. Data were analyzed with one-way ANOVA. At 0 to 14 days, the pZnO and mZnO-800 groups had greater average daily gain compared with control ( P < 0.05). Gain to feed ratio (G : F) in the same time interval was higher in pZnO group compared with control thus resulting in higher BW ( P < 0.05). At day 14, ileum villi height in mZnO-800 pigs was 343 µm v. 309 and 317 µm in control and pZnO, respectively ( P < 0.01) and villi : crypts ratio (V : C), as well as cells positive to proliferating cell nuclear antigen (PCNA), were greater in all treated groups compared with control ( P < 0.01). In mZnO-800 group, interferon-γ mRNA was the lowest ( P = 0.02), and both pharmacological ZnO and mZnO reduced tumor necrosis factor-α protein level ( P < 0.0001). Compared with pZnO group, mZnO-800 increased occludin and zonula occludens-1 protein level (1.6-fold and 1.3-fold, respectively; P < 0.001). At day 42, both groups receiving microencapsulated ZnO had 1.7 kg greater BW than control and did not differ from pZnO group ( P = 0.01); ileum villi height and V : C ratio were the greatest for pZnO compared with the other groups, whereas PCNA-positive cells were the most numerous in mZnO-800 group ( P < 0.001).In conclusion, pigs receiving low doses of microencapsulated ZnO had G : F comparable with those receiving pharmacological level of ZnO in the overall post-weaning phase. Moreover, in the first 2 weeks post-weaning, microencapsulated ZnO effect on inflammatory status and ileum structure and integrity was comparable with pharmacological ZnO.

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Zinc in gastrointestinal and liver disease

Cited by 67 publications

References 143 publications

Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

Effects of Dietary Zinc and l-Arginine Supplementation on Total Antioxidants Capacity, Lipid Peroxidation, Nitric Oxide, Egg Weight, and Blood Biochemical Values in Japanase Quails

Low doses of microencapsulated zinc oxide improve performance and modulate the ileum architecture, inflammatory cytokines and tight junctions expression of weaned pigs

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