Zinc in kidney disease.

Mahajan, S K

doi:10.1080/07315724.1989.10720305

Cited by 43 publications

(27 citation statements)

References 50 publications

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“…Depressed serum and plasma zinc levels have been reported in patients with chronic renal disease (4,46 (47), increased urinary and fecal losses (48), imparied intestinal absorption (49,50), decreased protein binding (4), or a shift from plasma to erythrocyte zinc (51). The present study could not demonstrate a positive relationship between serum zinc and renal function.…”

Section: Discussioncontrasting

confidence: 48%

Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium

Thijs¹,

Staessen²,

Améry³

et al. 1992

Environ Health Perspect

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This report investigated the distribution of serum zinc and the factors determining serum zinc concentration in a large random population sample. The 1977 participants (959 men and 1018 women), 20-80 years old, constituted a stratified random sample of the population of four Belgian districts, representing two areas with low and two with high environmental exposure to cadmium. For each exposure level, a rural and an urban area were selected. The serum concentration of zinc, frequently used as an index for zinc status in human subjects, was higher in men (13.1 ,umole/L, range 6.5-23.0 ,umole/L) than in women (12.6 Rmole/L, range 6.3-23.2 Rmole/L).In men, 20% of the variance of serum zinc was explained by age (linear and squared term, R = 0.29), diurnal variation (r = 0.29), and total cholesterol (r = 0.16). After adjustment for these covariates, a negative relationship was observed between serum zinc and both blood (r = -0.10) and urinary cadmium (r = -0.14). In women, 11% of the variance could be explained by age (linear and squared term, R = 0.15), diurnal variation in serum zinc (r = 0.27), creatinine clearance (r = -0.11), log y-glutamyltranspeptidase (r = 0.08), cholesterol (r = 0.07), contraceptive pill intake (r = -0.07), and log serum ferritin (r = 0.06). Before and after adjustment for significant covariates, serum zinc was, on average, lowest in the two districts where the body burden of cadmium, as assessed by urinary cadmium excretion, was highest. These results were not altered when subjects exposed to heavy metals at work were excluded from analysis.

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Section: Discussioncontrasting

confidence: 48%

Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium

Thijs¹,

Staessen²,

Améry³

et al. 1992

Environ Health Perspect

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“…Not only urinary erythropoietin excretion but also uri nary loss of trace metals such as iron, zinc and copper has been also suggested to be involved in the etiology of ane mia in NS [20][21][22], However, the possibilities arc unlikely because serum levels of these elements were within nor mal range in the present case.…”

Section: Discussioncontrasting

confidence: 47%

Successful Erythropoietin Treatment for Severe Anemia in Nephrotic Syndrome without Renal Dysfunction

Ishimitsu

Ono²,

Sugiyama³

et al. 1996

Nephron

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A 62-year-old woman presented with nephrotic syndrome and severe anemia although the renal function was not impaired. Renal biopsy revealed the histology of membranoproliferative glomerulonephritis, and the proteinuria was resistant to steroid therapy. Iron deficiency, bleeding and other causes of anemia were ruled out, however, her serum erythropoietin level was inappropriately low. The anemia was rapidly corrected by administration of recombinant human erythropoietin. It is suggested that inappropriately low erythropoietin level, in part at least, accounts for the anemia in nephrotic syndrome. It is proposed that erythropoietin therapy should be taken into consideration for severe anemia in nephrotic syndrome even when the renal function is not impaired.

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“…1 The mechanism of taste alteration is not well understood, but felt to be a consequence of uremia, 2 and prevalence is higher among patients with lower native GFR. 5 Another potential explanation for taste alteration in hemodialysis patients is zinc deficiency, 6 which is commonplace due to high dialytic removal. 7 …”

Section: Introductionmentioning

confidence: 99%

Altered Taste Perception and Nutritional Status Among Hemodialysis Patients

Lynch

Curhan

et al. 2013

Journal of Renal Nutrition

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Objective To examine the association between altered taste perception and nutritional status among hemodialysis patients. Design We performed a post-hoc analysis of data from the HEMO Study (n = 1745). Taste perception was assessed at baseline and then updated annually using an item from a quality of life survey, which asked “during the past 4 weeks, to what extent were you bothered by loss of taste?” Responses were categorized as normal taste perception if subjects answered “not at all” or altered taste perception if they reported any degree of bother. Time-updated logistic regression models were used to evaluate predictors of altered taste perception. Time-updated linear regression models were used to examine the association between altered taste perception and indices of nutritional status. Multivariable proportional hazards and Poisson models were used to assess association between altered taste perception and mortality and hospitalization, respectively. Results At baseline, 34.6% reported altered taste perception, which was associated with poorer baseline nutritional status. On time-updated analysis, altered taste perception was associated with a persistently higher proportion of subjects requiring enteral nutritional supplements and lower serum albumin, serum creatinine, normalized protein catabolic rate, protein intake, sodium intake, and mid-arm muscle circumference. Altered taste perception at baseline was independently associated with increased all-cause mortality: adjusted HR (95% CI) of 1.17 (1.01–1.37), although not with increased rate of hospitalization. Conclusion Altered taste perception was common among prevalent hemodialysis patients and independently associated with poorer indices of nutritional status and increased all-cause mortality.

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Zinc in kidney disease.

Cited by 43 publications

References 50 publications

Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium

Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium

Successful Erythropoietin Treatment for Severe Anemia in Nephrotic Syndrome without Renal Dysfunction

Altered Taste Perception and Nutritional Status Among Hemodialysis Patients

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