Zinc in the treatment of idiopathic sudden sensorineural hearing loss

Yang, Chao‐Hui; Ko, Ming-Tse; Peng, Jigen; Hwang, Chung‐Feng

doi:10.1002/lary.21291

Cited by 35 publications

(47 citation statements)

References 36 publications

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“…The causes of most cases of SSNHL cannot be identified and are thought to be idiopathic. Although spontaneous recovery may occur in some patients with sudden hearing loss, many different treatment regiments have been suggested (1), including corticosteroids, antiviral drugs, vasoactive agents, and antioxidants (2). Among these, systemic steroids are commonly used as a standard therapy (3).…”

mentioning

confidence: 99%

Comparison of Intratympanic Steroid Injection, Hyperbaric Oxygen and Combination Therapy in Refractory Sudden Sensorineural Hearing Loss

Yang¹,

Wu²,

Hwang³

2013

Otology &Amp; Neurotology

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mentioning

confidence: 99%

Comparison of Intratympanic Steroid Injection, Hyperbaric Oxygen and Combination Therapy in Refractory Sudden Sensorineural Hearing Loss

Yang¹,

Wu²,

Hwang³

2013

Otology &Amp; Neurotology

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“…Moreover, it is an expensive and time-consuming treatment method. Other possible options include medications such as antiviral agents [23], vasodilators (such as carbogen, alprostadil, naftidrofuryl, and low-molecular-weight dextran) [24], high-dose vitamins [25], [26], and zinc supplementation [27]. However, the effects of these agents have not been sufficiently studied and there is no evidence to support their use.…”

Section: Discussionmentioning

confidence: 99%

Optimal Dosage of Methylprednisolone for the Treatment of Sudden Hearing Loss in Geriatric Patients: A Propensity Score-Matched Analysis

2014

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We aimed to compare the treatment outcomes and the occurrence rates of adverse events associated with different steroid regimens in geriatric patients (aged 65 years or older) with unilateral idiopathic sudden sensorineural hearing loss (ISSNHL). After thorough medical chart reviews of 109 patients with ISSNHL between May 2006 and December 2013, we performed a propensity score-matched analysis using previously known prognostic factors, steroid regimens, and other cointerventions. Patients were divided based on their steroid regimens into group I (which initially received 48 mg of methylprednisolone daily with a subsequently tapered dose) and group II (which initially received 24 mg of methylprednisolone daily with a subsequently tapered dose). We compared final hearing and the occurrence of adverse events between the two groups. As a result, 20 pairs of propensity score-matched patients (n = 40) were enrolled. Group I patients showed better final hearing levels compared with group II patients (42.00±22.35 dB and 57.38±26.40 dB, respectively), although this difference was marginally significant (p = 0.058). Based on the comparative analysis of each of the frequencies in the final audiograms, lower hearing thresholds at 2 KHz were observed in group I (p = 0.049). There was no significant difference in the occurrence of adverse effects between the two groups (p>0.05). In conclusion, conventional steroid regimens produced adverse event occurrence rates that were similar to those of low-dose treatment but may also have produced superior hearing recovery. The use of steroid dose reduction in geriatric patients with ISSNHL is not preferable to conventional steroid regimens.

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“…Zinc has been studied as a supplemental therapy to standard oral steroid therapy in two trials. The earlier study found that patients in the zinc group had greater improvement in hearing gain after therapy, and serum zinc levels were correlated to post‐treatment PTA . A more recent study was unable to replicate these findings, and instead showed that zinc supplementation had no significant improvement in PTA or speech discrimination scores (SDS) compared with systemic steroids alone .…”

Section: Other (Nonsteroidal) Therapiesmentioning

confidence: 96%

“…The earlier study found that patients in the zinc group had greater improvement in hearing gain after therapy, and serum zinc levels were correlated to post-treatment PTA. 26 A more recent study was unable to replicate these findings, and instead showed that zinc supplementation had no significant improvement in PTA or speech discrimination scores (SDS) compared with systemic steroids alone. 27 No consensus exists on the use of zinc or magnesium in the management of SSNHL to date, as they are not explicitly mentioned in practice guidelines.…”

Section: Mineral Therapies (Zinc)mentioning

confidence: 96%

“…Full texts of the reports were retrieved for the studies that appeared to fit the eligibility criteria for inclusion in this review. The result of the systematic search and selected studies are included in Table , which lists the interventions (steroid or alternative therapy) and the main outcome measures with interpretation …”

Section: Evidence and Therapeutic Alternativesmentioning

confidence: 99%

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Evaluation and Treatment of Acute and Subacute Hearing Loss: A Review of Pharmacotherapy

et al. 2017

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Among various forms of hearing loss, there are acute (within 72 hrs) or subacute (weeks to months) presentations that may be reversible with early pharmacological intervention. The workup of a patient presenting with hypoacusia includes the usual history and physical examination in conjunction with an audiometric assessment in order to categorize the hearing loss as conductive, sensorineural, or mixed. Sudden sensorineural hearing loss and autoimmune inner ear disease are acute and subacute forms of sensorineural hypoacusia most likely to be reversed with prompt pharmacological intervention. Systemic or local corticosteroid therapy has the most evidence of benefit in patients with sudden sensorineural hypoacusia and is the best available first line therapy noted in clinical practice guidelines. Alternative immunosuppressant therapies have not been well studied, and many have serious toxicities that further complicate the benefit-risk assessment. There are no randomized comparisons of corticosteroid dosing regimens that evaluated clinically important outcomes, so expert opinion must serve as the basis for dosing recommendations. Clinicians need to involve patients with hypoacusia in the shared decision-making process, since partial or complete reversal of hearing loss can have substantial quality-of-life implications for affected patients.

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Zinc in the treatment of idiopathic sudden sensorineural hearing loss

Abstract: Zinc supplementation may enhance the hearing recovery of SSNHL patients. Its antioxidant and anti-inflammatory effects may help reduce the oxidative stress of the cochlea in SSNHL, implying a new direction in the treatment of this disease.

Cited by 35 publications

References 36 publications

Comparison of Intratympanic Steroid Injection, Hyperbaric Oxygen and Combination Therapy in Refractory Sudden Sensorineural Hearing Loss

Comparison of Intratympanic Steroid Injection, Hyperbaric Oxygen and Combination Therapy in Refractory Sudden Sensorineural Hearing Loss

Optimal Dosage of Methylprednisolone for the Treatment of Sudden Hearing Loss in Geriatric Patients: A Propensity Score-Matched Analysis

Evaluation and Treatment of Acute and Subacute Hearing Loss: A Review of Pharmacotherapy

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