Zinc-Induced Copper Deficiency in an Infant

Botash, Ann S.; Nasca, Joseph; Dubowy, Ronald L.; Weinberger, Howard L.; Oliphant, Michael

doi:10.1001/archpedi.1992.02160180069019

Cited by 31 publications

(31 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…28 Zinc competes with copper for gastrointestinal uptake, and increased zinc intake can induce copper deficiency, causing neutropenia. 80 The IL-2 response is reduced in copper deficiency. 81 Serum copper or ceruloplasmin levels reflect the severity of malnutrition.…”

Section: Zinc and Copper Deficiencymentioning

confidence: 99%

Mechanisms of nutrient modulation of the immune response

Cunningham‐Rundles

McNeeley

Moon

2005

Journal of Allergy and Clinical Immunology

451

330

View full text Add to dashboard Cite

Section: Zinc and Copper Deficiencymentioning

confidence: 99%

Mechanisms of nutrient modulation of the immune response

Cunningham‐Rundles

McNeeley

Moon

2005

Journal of Allergy and Clinical Immunology

451

330

View full text Add to dashboard Cite

“…Often, excessive Zn is added to foxes' feed to avoid Zn deficiency and to improve appetite. However, high Zn may result in lower Cu utilization and Cu deficiency when the Cu addition is insufficient [14,15]. Therefore, the objectives of the present study were to investigate the effects of dietary Cu and Zn supplements and their interaction on growth performance, tissue mineral retention, antioxidant status, and fur quality of growing-furring blue foxes.…”

Section: Introductionmentioning

confidence: 98%

Effects of Dietary Copper and Zinc Supplementation on Growth Performance, Tissue Mineral Retention, Antioxidant Status, and Fur Quality in Growing-Furring Blue Foxes (Alopex lagopus)

Liu

Zhang

et al. 2015

Biol Trace Elem Res

View full text Add to dashboard Cite

A 4×2 factorial experiment with four supplemental levels of copper (0, 20, 40, or 60 mg copper per kg dry matter) from copper sulfate and two supplemental levels of zinc (40 or 200 mg zinc per kg dry matter) from zinc sulfate was conducted to investigate the effects of dietary copper and zinc supplementation on growth performance, tissue mineral retention, antioxidant status, and fur quality in growing-furring blue foxes. One hundred and twenty healthy 15-week-old male blue foxes were randomly allocated to eight dietary treatments with 15 replicates per treatment for a 70-day trial from mid-September to pelting in December. The average daily gain and feed conversion ratio were increased with copper supplementation in the first 35 days as well as the overall period (P<0.05). In addition, copper supplementation tended to increase feed intake during the first 35 days (P<0.10). Diets supplemented with 200 mg/kg zinc did not affect body gain (P>0.10) and feed intake (P>0.10) but improved feed conversion (P<0.05) compared with those supplemented 40 mg/kg zinc throughout the experiment. No copper×zinc interaction was observed for growth performance except that a tendency (P=0.09) was found for feed intake in the first 35 days. Supplementation of copper or zinc improved crude fat digestibility (P<0.01) but had no effects on the digestibility of other nutrients. Fecal copper was increased with both copper (P<0.01) and zinc addition (P<0.05). However, fecal zinc was affected only by dietary zinc addition (P<0.01). Mineral contents in serum and kidney were not affected by dietary treatments (P>0.05). However, the level of copper in the liver was increased with copper supplementation (P<0.05) and tended to decrease with zinc supplementation (P=0.08). Dietary zinc addition tended to increase the activity of alkaline phosphatase (P=0.07). The activities of copper-zinc superoxide dismutase and catalase tended to increase by copper (P=0.08) and zinc addition (P=0.05). Moreover, a copper×zinc interaction was observed for catalase in the experiment (P<0.05). Serum malondialdehyde concentration decreased with the increasing of dietary copper and zinc levels (P<0.05). The activity of glutathione peroxidase tended to increase by copper addition (P=0.09). For fur quality, foxes fed diets supplemented with high copper had larger skin length and darker pelts than those fed the basal diet without copper addition (P<0.05). In conclusion, this study demonstrated that dietary copper and zinc supplementation can improve growth by increasing feed intake and improving fat digestibility. Additionally, copper and zinc can enhance the antioxidant capacity of blue foxes. This study also indicates that additional zinc up to 200 mg/kg did not exert significant adverse effects on the copper metabolism of growing-furring blue foxes.

show abstract

“…Among these, several reports indicated that overt zinc deficiency occurs in early infancy probably due to an abnormally low zinc concentration in breast milk (8-10, 13, 15, 77, 18). Also, in the last two decades, many investigators reported cases of copper deficiency during infancy and childhood (20)(21)(22)(23)(24)(25)(26)(27)(28)(29). Therefore, the importance of these minerals in infant nutrition is well recognized.…”

mentioning

confidence: 99%