2003
DOI: 10.1002/bdra.10046
|View full text |Cite
|
Sign up to set email alerts
|

Zinc influences the in vitro development of peri‐implantation mouse embryos

Abstract: These data support an important role for Zn in promoting differentiation and cell survival in the early embryo and suggest that sub-optimal nutrition is an important factor that contributes to defects in primary germ layers and early embryonic loss.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
16
0

Year Published

2004
2004
2021
2021

Publication Types

Select...
6

Relationship

2
4

Authors

Journals

citations
Cited by 22 publications
(18 citation statements)
references
References 53 publications
2
16
0
Order By: Relevance
“…Consistent with the above reports, subsequent work with rat and mouse model systems revealed that pre-implantation embryo development can be markedly influenced by periods of maternal zinc deficiency as short as 3-4 days (Hurley and Shrader, 1975;Peters et al, 1991). In an in vitro mouse model system, peri-implantation embryo defects have also been demonstrated (Hanna et al, 2003). In rat (Hurley and Swenerton, 1966) and monkey (Swenerton and Hurley, 1980) models, the consumption of a severely zincdeficient prior to pregnancy can result in a disruption of the estrus cycle and mating may not take place.…”
Section: Timing and Rapid Effects Of Severe Maternal Zinc Deficiencysupporting
confidence: 52%
See 2 more Smart Citations
“…Consistent with the above reports, subsequent work with rat and mouse model systems revealed that pre-implantation embryo development can be markedly influenced by periods of maternal zinc deficiency as short as 3-4 days (Hurley and Shrader, 1975;Peters et al, 1991). In an in vitro mouse model system, peri-implantation embryo defects have also been demonstrated (Hanna et al, 2003). In rat (Hurley and Swenerton, 1966) and monkey (Swenerton and Hurley, 1980) models, the consumption of a severely zincdeficient prior to pregnancy can result in a disruption of the estrus cycle and mating may not take place.…”
Section: Timing and Rapid Effects Of Severe Maternal Zinc Deficiencysupporting
confidence: 52%
“…It has been suggested that increased cell death is a major contributor to the reduction in lymphopoiesis that is observed in zinc-deficient animals (Fraker, 2005). Periimplantation (Hanna et al, 2003) and mid-gestation embryos from zinc-deficient dams are also characterized by increased cell death and caspase-3-like activity, indicating that zinc deficiency negatively affects apoptosis in vivo and can contribute to abnormal embryo development (Jankowski-Hennig et al, 2000).…”
Section: Zinc Deficiency-induced Cell Deathmentioning
confidence: 98%
See 1 more Smart Citation
“…Zn-supplemented media during in vitro maturation (IVM) of porcine blastocysts significantly decreased ROS levels in mature oocytes, likely in association with increased superoxide dismutase (SOD) activities and higher intracellular glutathione levels [37]. Similarly, Zn media supplementation (3.6-19 μmol) was associated with better quality mouse embryos [38,39], yet higher concentrations (25 μmol) were embryotoxic [39]. Still, an earlier study of 33 human follicles found no association between Zn and oocyte fertilization during IVF [40].…”
Section: Discussionmentioning
confidence: 99%
“…In these experiments, the embryos cultured in the low zinc medium or developed at maternal zinc deficiency displayed increased rates of apoptosis in all the structures derived from neural crest cells, leading to developmental defects and early embryo abortion (Rogers et al, 1995;Jankowski-Hennig et al, 2000;Hanna et al, 2003;Clegg et al, 2005). A drop of intracellular zinc content found in the early Norway spruce embryos upon transition from living cells in the embryonal masses to the dying terminally differentiated cells in the suspensors (Fig.…”
Section: Depletion Of Intracellular Zinc Induces Ectopic Cell Death Imentioning
confidence: 92%