Zinc inhibition of calmodulin: A proposed molecular mechanism of zinc action on cellular functions

Brewer, George J.; Aster, Jon C.; Knutsen, Conrad A.; Kruckeberg, Walter C.

doi:10.1002/ajh.2830070107

Cited by 85 publications

(31 citation statements)

References 35 publications

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“…In the case of malignant tumour development which is characterised by a very intensive cellular proliferation and increased blood supply of Zn, the element may be essential for accelerated tumour tissue metabolic processes and its rapid growth. It was reported in experimental studies that increased Zn demand of neoplastic tissue is related to the acceleration of cellular metabolism and a higher activity of intracellular Zndependent enzymes (4,13,29). Furthermore, cellular accumulation of Zn inhibits the apoptosis of neoplastic cells (31).…”

Section: Discussionmentioning

confidence: 99%

Total antioxidative capacity and zinc concentration in dogs suffering from perianal tumours

Brodzki

Tatara

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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The aim of the study was to determine total antioxidative capacity (TAC) and zinc concentration in serum of dogs suffering from perianal tumours just before the start of the antihormonal treatment (AHT) and one and six months later. The study was performed on 45 dogs divided into two groups: control group suffering from non-malignant tumours (N = 24) and a group with malignant neoplastic changes (N = 21). Serum TAC and zinc concentrations were measured using photometric and atomic absorption spectrophotometric methods. Six months after the start of the AHT, TAC was significantly lower by 10.6% in dogs with malignant tumours when compared to controls (P = 0.03). In the non-malignant group, serum zinc concentration was higher before the treatment than in the malignant group, while the opposite results were observed six months later (P < 0.001). In the non-malignant group, gradually decreasing values of serum zinc concentration at each stage of the investigation were observed, while the opposite results were obtained in the malignant group (P < 0.05). The obtained results indicate that malignant neoplastic process is associated with significantly reduced TAC. Determination of serum zinc concentration in dogs with nonmalignant and malignant perianal tumours may have practical diagnostic and prognostic values and may serve towards increasing the effectiveness of AHT monitoring.

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Section: Discussionmentioning

confidence: 99%

Total antioxidative capacity and zinc concentration in dogs suffering from perianal tumours

Brodzki

Tatara

et al. 2015

Bulletin of the Veterinary Institute in Pulawy

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“…The trace element zinc an tagonizes many calcium-mediated processes [1,6], and spe cifically inhibits some calmodulin-dependent functions [2]. We therefore hypothesized that zinc might influence Prl se cretion.…”

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confidence: 99%

Zinc May Have a Physiological Role in Regulating Pituitary Prolactin Secretion

Thorner

MacLeod

1983

Neuroendocrinology

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We studied the in vitro influence of physiologically relevant zinc concentrations on the pituitary synthesis and secretion of prolactin (Prl). Zinc in concentrations between 1 and 10 μM reduced Prl secretion and, to a milder extent, synthesis, but not basal or stimulated growth hormone (GH) or LH release. At a supraphysiological concentration of 100 μM, zinc markedly decreased Prl synthesis and secretion, but increased LH secretion. The ability of a physiological zinc concentration to influence Prl secretion suggests that this trace element may have a role in the in vivo regulation of Prl release.

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“…It has also been reported by Brewer et al that ZnZt ions inhibit the calmodulin-stimulated activity of membranebound Ca-ATPase. According to Brewer et al Zn2+ inhibition of calmodulin provides a rational molecular mechanism for the diverse cellular inhibitory effects of zinc [18].…”

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confidence: 99%

Characterization of the Ca²⁺ Binding Sites of Calmodulin from Bovine Testis Using ⁴³Ca and ¹¹³Cd NMR

Andersson

Drakenberg

Forsén

et al. 1982

European Journal of Biochemistry

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The exchange rates of Ca2+ ions to the two classes of sites on calmodulin have been determined from the temperature dependence of the 43Ca NMR line width. The exchange rates were found to differ by a factor of about 40 at room temperature. The apparent pK value for one of these classes was estimated from the pH dependence of the 43Ca line width.The pK values of the two-high-affinity sites were found to differ about 0.1 -1. Zn2+ ions were shown to bind to calmodulin and affect the exchange rates of Ca2+ and Cd2+ for all four sites.

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Zinc inhibition of calmodulin: A proposed molecular mechanism of zinc action on cellular functions

Cited by 85 publications

References 35 publications

Total antioxidative capacity and zinc concentration in dogs suffering from perianal tumours

Total antioxidative capacity and zinc concentration in dogs suffering from perianal tumours

Zinc May Have a Physiological Role in Regulating Pituitary Prolactin Secretion

Characterization of the Ca²⁺ Binding Sites of Calmodulin from Bovine Testis Using ⁴³Ca and ¹¹³Cd NMR

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Zinc inhibition of calmodulin: A proposed molecular mechanism of zinc action on cellular functions

Cited by 85 publications

References 35 publications

Total antioxidative capacity and zinc concentration in dogs suffering from perianal tumours

Total antioxidative capacity and zinc concentration in dogs suffering from perianal tumours

Zinc May Have a Physiological Role in Regulating Pituitary Prolactin Secretion

Characterization of the Ca2+ Binding Sites of Calmodulin from Bovine Testis Using 43Ca and 113Cd NMR

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Characterization of the Ca²⁺ Binding Sites of Calmodulin from Bovine Testis Using ⁴³Ca and ¹¹³Cd NMR