Zinc L‐carnosine protects against mucosal injury in portal hypertensive gastropathy through induction of heat shock protein 72

Mikami, Koji; Otaka, Michiro; Watanabe, Dai; Goto, Takashi; A, Endoh; Miura, Kouichi; Ohshima, Shigetoshi; Yoneyama, Kazuo; Sato, Michiko; Shibuya, Tomomi; Segawa, Daisuke; Kataoka, Ei; Yoshino, Ryutaro; Takeuchi, Satoko; Sato, Wataru; Odashima, Masaru; Watanabe, Sumio

doi:10.1111/j.1440-1746.2006.04328.x

Cited by 29 publications

(19 citation statements)

References 48 publications

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“…This result may indicate the cytoprotective beneficial impact of these agents against hypoxia induced renal tissue injury. There is an evidence that carnosine and arginine can regulate intracellular HSP-70 expression which is essential for preventing organ dysfunction (Chatterjee et al 2005;Mikami et al 2006;Wu et al 2013) . The current result also revealed that a marked elevation in the serum HIF-1α of hypoxic rats compared with normal animals.…”

Section: Discussionmentioning

confidence: 99%

Regulating Effect Of Carnosine And /Or L- Arginine On The Expression Of Inflammatory Molecules Induced Nephropathy In The Hypoxic Rat Model

Al-Rasheed

Fadda

Mohamed

et al. 2016

Braz. arch. biol. technol.

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This study aimed to explore the effective role of carnosine and /or L-arginine pro-inflammatory molecules, including tumor necrosis factor-α (TNF-α) , Creactive protein (CRP), vascular endothelial growth factor (VEGF) and heat shock protein -70 (HSP-70) as well as interleukin-6 (IL-6) in renal tissue compared to NaNO2 hypoxic rats . Also, the two agents successfully down modulated the alteration in the serum hypoxia inducible factor 1α (HIF 1α

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Section: Discussionmentioning

confidence: 99%

Regulating Effect Of Carnosine And /Or L- Arginine On The Expression Of Inflammatory Molecules Induced Nephropathy In The Hypoxic Rat Model

Al-Rasheed

Fadda

Mohamed

et al. 2016

Braz. arch. biol. technol.

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“…By 8 weeks, a micronodular cirrhosis takes place 31 . It has been used mainly by intraperitoneal injection 12 or oral administration 20 , the dosage 0,2 to 5ml/kg and LC is achieved between 36 hours to 18 weeks 15,20,11,24 .…”

Section: Discussionmentioning

confidence: 99%

Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection

Marques¹,

Chaib²,

Fonseca³

et al. 2012

Acta Cir. Bras.

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PURPOSE:To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. METHODS:This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011. RESULTS:The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery. CONCLUSION:For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it.

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“…Secondly, they also showed that high and low doses of carnosine affected the catalase or glutathione peroxidase activities at the same rate. Generally, the cumulative dose of carnosine administered is approximately 250-300 mg/ kg [19][20][21]. All efforts were made to minimize animal suffering and to reduce the number of animals used in this experiment.…”

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confidence: 99%

Protection Against Adriamycin-Induced Cardiomyopathy by Carnosine in Rats: Role of Endogenous Antioxidants

Dursun

Taşkın

Öztürk

2010

Biol Trace Elem Res

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The aim of this study was to investigate the effects of carnosine, a biological antioxidant, on the acute cardiac damage induced by a single dose of adriamycin in rats. The experimental design consisted of four groups: Control (saline, i.p.); carnosine (CAR; 10 mg/kg/day, i.p.); adriamycin (ADR; 16 mg/kg on the 14th day, i.p.); carnosine with adriamycin. Carnosine was given 2 weeks before and following adriamycin treatment. Blood samples were collected for analysis of plasma creatine kinase (CK) and plasma antioxidant enzymes, glutathione peroxidase (GSH-Px), Cu, Zn-superoxide dismutase (SOD), and catalase (CAT). The rats were then sacrificed, and the hearts were autopsied for hemodynamic study, ECG, and histopathological examination. Results showed that adriamycin produced evident cardiac damage revealed by hemodynamic change, histological alterations, decreased plasma antioxidant enzymes activities, and increased lipid peroxidation to the control value. Carnosine treatment led to significant attenuation of adriamycin-induced cardiomyopathy revealed by normalization of the LVDP, ST interval, CK, SOD, GSH-Px, CAT, and lipid peroxidation. An increase in oxidative stress and inactivation of SOD, GSH-Px, CAT by a single dose of adriamycin were prevented when carnosine was given 2 weeks before and on the same day adriamycin treatment was administered.

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Zinc L‐carnosine protects against mucosal injury in portal hypertensive gastropathy through induction of heat shock protein 72

Abstract: Zinc derivatives, especially zinc L-carnosine, protected portal hypertensive gastric mucosa with increased hsp72 expression in cirrhotic rats. It is postulated that zinc L-carnosine may be beneficial to the mucosal protection in PHG as a 'chaperone inducer'.

Cited by 29 publications

References 48 publications

Regulating Effect Of Carnosine And /Or L- Arginine On The Expression Of Inflammatory Molecules Induced Nephropathy In The Hypoxic Rat Model

Regulating Effect Of Carnosine And /Or L- Arginine On The Expression Of Inflammatory Molecules Induced Nephropathy In The Hypoxic Rat Model

Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection

Protection Against Adriamycin-Induced Cardiomyopathy by Carnosine in Rats: Role of Endogenous Antioxidants

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