Zinc, magnesium and NMDA receptor alterations in the hippocampus of suicide victims

Sowa-Kućma, Magdalena; Szewczyk, Bernadeta; Sadlik, Krystyna; Piekoszewski, Wojciech; Trela, Franciszek; Opoka, Włodzimierz; Poleszak, Ewa; Pilc, Andrzej; Nowak, Gabriel

doi:10.1016/j.jad.2013.08.009

Cited by 64 publications

(43 citation statements)

References 86 publications

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“…We hypothesized that DISC1 may be associated with lifetime history of suicide attempts in opioid-dependent individuals via interactions with N-methyl-D-aspartate receptors (NMDA receptors). Previous research identified a reduction in the potency of NMDA receptors in the hippocampus of suicide victims when compared with sudden-death controls (Sowa-Kuc;ma et al, 2013). In addition, genetic alternation of glutamatergic receptors has been linked with suicide attempts (Sokolowski et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample

Fudalej

Jakubczyk

Piwoński

et al. 2016

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: Disrupted-in-schizophrenia 1 (DISC1) has been linked to vulnerability to a variety of psychiatric disorders and neuropsychiatric phenotypes. However, DISC1 has not been frequently examined as a potential risk factor for substance dependence. An association between opioid dependence and DISC1 rs2738888 polymorphism has been recently reported. In addition, opioid dependence was associated with rs6419156 located close to the protein phosphatase 3 catalytic subunit alpha isoform (PPP3CA) gene. The aim of the present study was to examine the associations between opioid dependence with rs2738888 and rs6419156 in an independent sample. Method: The selected polymorphisms were genotyped in a sample of 392 individuals (69.9% male) diagnosed as alcohol-and/or opioid-dependent. A control group (n = 257; 67.7% male) was derived from the Polish National Health Survey (N = 14,350). Results: The frequency of rs2738888 C allele was higher in controls than in opioid-dependent cases (OR = 0.65, p = .045). Phenotypic-oriented analyses performed within opioiddependent individuals revealed the association between lifetime suicide attempt and rs2738888. The C allele of rs2738888 had a protective effect on lifetime suicide attempt in opioid-dependent patients (OR = 0.25, p = .003). Rs6419156 was not associated with substance dependence in the examined sample. Conclusions: The DISC1 may play an important role in vulnerability to opioid dependence. In addition, DISC1 may also be a genetic risk factor for suicide attempt in opioid-dependent individuals.

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Section: Discussionmentioning

confidence: 99%

DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample

Fudalej

Jakubczyk

Piwoński

et al. 2016

J. Stud. Alcohol Drugs

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“…N-methyl-d-aspartate (NMDA) (glutamate) has an important anti-depression and anti-anxiety effect. Zinc and magnesium, the potent antagonists of the NMDA receptor complex, are involved in the pathophysiology of depression and anxiety, and exhibit antidepressant and anti-anxiety activities; therefore, reduction of zinc and magnesium levels may lead to functional NMDA receptor hyperactivity (Doboszewska et al, 2015;Sowa-Kucma et al, 2013). In addition, magnesium controls HPA (Hypothalamic-pituitary-adrenal) activity, thereby decreases anxiety symptoms by the reduction of corticotrophin releasing hormone (CRH) level (Sartori, Whittle, Hetzenauer, & Singewald, 2012).…”

Section: Discussionmentioning

confidence: 99%

Relationship of Zinc and Magnesium Serum Levels with Postpartum Depression in Tabriz-Iran

Edalati-Fard¹,

Mirghafourvand²,

Mohammad‐Alizadeh‐Charandabi³

et al. 2016

GJHS

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Objective: According to the World Health Organization, depression will be the second prevalent problem after ischemic heart diseases by the year 2020. Postpartum depression (PPD) as a major depressive episode has devastating impacts on the health of mother, newborn, infant, and even the whole family. This study was conducted to investigate the relationship of zinc and magnesium serum levels with PPD, as one of the commonly assumed causes of depression. Methods:This cross-sectional study was done on 122 postpartum women aged 18 years and more in two educational hospitals and one non-educational hospital in Tabriz-Iran, 2015. The eligible women were selected using convenience sampling method. Then, the demographic characteristics questionnaire and Edinburgh Depression Scale were completed by participants, and 5cc of blood sample was drawn from each participant. For data analysis, logistic regression test was used. Results:The mean score of depression scale was 8.0 (SD: 4.7), meaning that 18.9% of mothers were depressed. Results indicated a significant inverse correlation between Edinburgh depression score and magnesium serum level (p= 0.001). However, there was no statistically significant relationship between the zinc serum level and Edinburgh depression score (p=0.831), in so far as based on logistic regression analysis, increased magnesium serum level decreased the odds of depression [Odds ratio: 0.05; CI 95%: 0.01 to 0.29].Conclusions: In this study, there was a significant inverse relationship between magnesium serum level and Edinburgh depression score.

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“…NMDA receptors are important for learning and memory (21). Some studies have emphasized the importance of the interference of muscarinic receptors type 1 and NMDA receptors on memory.…”

Section: Discussionmentioning

confidence: 99%

Effect of Magnesium Oxide Nanoparticles on Atropine-Induced Memory Impairment in Adult Male Mice

nootarki

Kesmati

Borujeni

2015

Avicenna J Neuro Psych Physio

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Zinc, magnesium and NMDA receptor alterations in the hippocampus of suicide victims

Cited by 64 publications

References 86 publications

DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample

DISC1 as a Possible Genetic Contribution to Opioid Dependence in a Polish Sample

Relationship of Zinc and Magnesium Serum Levels with Postpartum Depression in Tabriz-Iran

Effect of Magnesium Oxide Nanoparticles on Atropine-Induced Memory Impairment in Adult Male Mice

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