Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats

Shehata, Asmaa M; Salem, Fatma M S; El-Saied, Eiman M.; El-Rahman, Sahar S. Abd; Mahmoud, Mohamed Y.; Noshy, Peter A.

doi:10.2147/ijn.s307189

Cited by 29 publications

(20 citation statements)

References 60 publications

(68 reference statements)

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“…Ag-NPs reportedly showed disruption of glial cell line-derived neurotrophic factor (GDNF)/Fyn kinase signaling in spermatogonial stem cells [374]. On the other hand, zinc nanoparticles were shown to ameliorate Ag-NPsinduced adversely affected sperm motility morphology, viability, and concentration in adult male rats [375].…”

Section: Discussionmentioning

confidence: 99%

Nanotechnology Applications of Flavonoids for Viral Diseases

et al. 2021

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Recent years have witnessed the emergence of several viral diseases, including various zoonotic diseases such as the current pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Other viruses, which possess pandemic-causing potential include avian flu, Ebola, dengue, Zika, and Nipah virus, as well as the re-emergence of SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome) coronaviruses. Notably, effective drugs or vaccines against these viruses are still to be discovered. All the newly approved vaccines against the SARS-CoV-2-induced disease COVID-19 possess real-time possibility of becoming obsolete because of the development of ‘variants of concern’. Flavonoids are being increasingly recognized as prophylactic and therapeutic agents against emerging and old viral diseases. Around 10,000 natural flavonoid compounds have been identified, being phytochemicals, all plant-based. Flavonoids have been reported to have lesser side effects than conventional anti-viral agents and are effective against more viral diseases than currently used anti-virals. Despite their abundance in plants, which are a part of human diet, flavonoids have the problem of low bioavailability. Various attempts are in progress to increase the bioavailability of flavonoids, one of the promising fields being nanotechnology. This review is a narrative of some anti-viral dietary flavonoids, their bioavailability, and various means with an emphasis on the nanotechnology system(s) being experimented with to deliver anti-viral flavonoids, whose systems show potential in the efficient delivery of flavonoids, resulting in increased bioavailability.

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Section: Discussionmentioning

confidence: 99%

Nanotechnology Applications of Flavonoids for Viral Diseases

et al. 2021

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“…from AOP-Wiki) a Potential adverse outcomes (AOs) associated with the key event (AO nr. from AOP-Wiki a References Size: 50 nm Shape: Spherical Hydrodynamic size:113.4 ± 12.1 nm Zeta potential: − 12.30 ± 0.4 mV Adult male SD rats Oral gavage 50 mg/kg bw, 3 months Sperm Evaluation Sperm Motility, Concentration, and Viability by eosin staining Increased sperm morphological abnormalities Decreased sperm concentrations motility and viability Decreased sperm quantity or quality in the adult, Decreased fertility (ID505, ID520) Impaired fertility (ID330, ID406) [ 46 ] Oxidative Status GSH level, CAT activity and lipid peroxidation MDA content in testicular tissue by commercial kits Decreased CAT activity, Increased MDA content, Non-significant change in GSH level Decreased protection against oxidative stress, Occurance oxidative stress (ID210, ID1112, ID1249, ID1538, ID1869) Lipid Peroxidation (ID1445 or ID1511) Oxidative Damage (ID356) Hormonal Assessment Serum testosterone, LH and FSH by ELISA kit Decreased testosterone, LH and FSH levels Reduction, testosterone level (ID1613, ID1689, ID1612) Reduced, Gonadotropins (ID1986) Decreased sperm quantity or quality in the adult, Decreased fertility (ID505, ID520) DNA damage DNA strand breaks in testicular tissue by COMET assay Increased DNA damage Increased DNA damage (ID1194) DNA Damage (ID1194) Histopathological Examination Testis and Seminiferous tubules by Hematoxylin and Eosin (HE) staining Testis and Seminiferous tubules Histological alterations Necrotic spermatogonial cells Testicular atrophy (ID1506) Male reproductive tract malformations (ID348) Reduced, Reproductive Success (ID675) Size:45 nm PVP (< 1%) Zeta potential: − 20 mV New Zealand White male rabbits Intravenous …”

Section: Methodsmentioning

confidence: 99%

“…In vitro studies show that Ag NPs cause the alteration of germ cells and somatic cells function mainly due to cell membrane peroxidation, oxidative stress, mitochondrial damage, DNA damage, and apoptosis [ 43 – 45 ]. Necrotic spermatogonial cells, degenerative alterations in the cellular architecture of testes and epididymis are reported in in vivo models [ 46 , 47 ]. In some animal models, the accumulation of NPs in the testes is demonstrated [ 48 , 49 ].…”

Section: Introductionmentioning

confidence: 99%

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Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review

et al. 2023

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Background Adverse outcome pathways (AOPs) are conceptual frameworks that organize knowledge about biological interactions and toxicity mechanisms. They present a sequence of events commencing with initial interaction(s) of a stressor, which defines the perturbation in a biological system (molecular initiating event, MIE), and a dependent series of key events (KEs), ending with an adverse outcome (AO). AOPs have recently become the subject of intense studies in a view to better understand the mechanisms of nanomaterial (NM) toxicity. Silver nanoparticles (Ag NPs) are one of the most explored nanostructures and are extensively used in various application. This, in turn, has increased the potential for interactions of Ag NPs with environments, and toxicity to human health. The aim of this study was to construct a putative AOPs (pAOP) related to reproductive toxicity of Ag NPs, in order to lay the groundwork for a better comprehension of mechanisms affecting both undesired toxicity (against human cell) and expected toxicity (against microorganisms). Methods PubMed and Scopus were systematically searched for peer-reviewed studies examining reproductive toxicity potential of Ag NPs. The quality of selected studies was assessed through ToxRTool. Eventually, forty-eight studies published between 2005 and 2022 were selected to identify the mechanisms of Ag NPs impact on reproductive function in human male. The biological endpoints, measurements, and results were extracted from these studies. Where possible, endpoints were assigned to a potential KE and an AO using expert judgment. Then, KEs were classified at each major level of biological organization. Results We identified the impairment of intracellular SH-containing biomolecules, which are major cellular antioxidants, as a putative MIE, with subsequent KEs defined as ROS accumulation, mitochondrial damage, DNA damage and lipid peroxidation, apoptosis, reduced production of reproductive hormones and reduced quality of sperm. These successive KEs may result in impaired male fertility (AO). Conclusion This research recapitulates and schematically represents complex literature data gathered from different biological levels and propose a pAOP related to the reproductive toxicity induced by AgNPs. The development of AOPs specific to NMs should be encouraged in order to provide new insights to gain a better understanding of NP toxicity.

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“…In a previous study, we examined the effects of chitosan NP supplementation during IVM on porcine oocyte developmental competence and pre-implantation development in parthenogenetic and cloned embryos [ 11 ]. NPs containing various antioxidant materials can scavenge reactive oxygen species (ROS) and thus protect cellular molecules, such as lipids, proteins, and DNA, from oxidative stress, [ 11 , 12 , 13 ]. Therefore, many NPs are currently being used to improve the entire process of in vitro embryo production (IVP), such as gametes cryopreservation, oocyte in vitro maturation, and embryo culture [ 12 , 14 , 15 , 16 , 17 ], but some of these NPs exert toxic effects [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Modified Spirulina maxima Pectin Nanoparticles Improve the Developmental Competence of In Vitro Matured Porcine Oocytes

Roy

Qamar

Tanga

et al. 2021

Animals

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Molecular approaches have been used to determine metabolic substrates involved in the early embryonic processes to provide adequate culture conditions. To investigate the effect of modified Spirulina maxima pectin nanoparticles (MSmPNPs) on oocyte developmental competence, cumulus–oocyte complexes (COCs) retrieved from pig slaughterhouse ovaries were subjected to various concentrations of MSmPNPs (0, 2.5, 5.0, and 10 µg/mL) during in vitro maturation (IVM). In comparison to the control, MSmPNPs-5.0, and MSmPNPs-10 groups, oocytes treated with 2.5 µg/mL MSmPNPs had significantly increased glutathione (GSH) levels and lower levels of reactive oxygen species (ROS). Following parthenogenetic activation, the MSmPNPs-2.5 group had a considerably higher maturation and cleavage rates, blastocyst development, total cell number, and ratio of inner cell mass/trophectoderm (ICM:TE) cells, when compared with those in the control and all other treated groups. Furthermore, similar findings were reported for the developmental competence of somatic cell nuclear transfer (SCNT)-derived embryos. Additionally, the relative quantification of POU5F1, DPPA2, and NDP52 mRNA transcript levels were significantly higher in the MSmPNPs-2.5 group than in the control and other treated groups. Taken together, the current findings suggest that MSmPNP treatment alleviates oxidative stress and enhances the developmental competence of porcine in vitro matured oocytes after parthenogenetic activation and SCNT.

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Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats

Cited by 29 publications

References 60 publications

Nanotechnology Applications of Flavonoids for Viral Diseases

Nanotechnology Applications of Flavonoids for Viral Diseases

Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review

Modified Spirulina maxima Pectin Nanoparticles Improve the Developmental Competence of In Vitro Matured Porcine Oocytes

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